Peritumoral brain edema in meningiomas: correlations between magnetic resonance imaging, angiography, and pathology

Lee, Kyung Jin; Joo, Wonil; Rha, Hyoung Kyun; Park, Hae Kwan; Chough, Jung-Ki; Hong, Yong-Kil; Park, Chun-Keun

doi:10.1016/j.surneu.2007.03.027

Cited by 88 publications

(78 citation statements)

References 19 publications

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“…We found no significant correlation between the presence / degree of PBE and the age and sex of patients. This finding is consistent with most available data in the medical literature 6 , although Lee and collaborators 9 have found higher incidence of PBE in males than in females and age between 61 and 70 years was correlated with a higher degree of PBE in a study performed by Gurkanlar and collaborators 8 . Our study showed that tumors with PBE have bigger volumes than tumors without PBE.…”

Section: Discussionsupporting

confidence: 89%

“…Our study showed that tumors with PBE have bigger volumes than tumors without PBE. This finding is supported by the literature 6,7,9,11 , although some studies have not found a significant correlation between tumor volume and PBE 8,12 . Studies show that some patients with meningiomas have a decreased peritumoral blood flow and conclude that the edema may have an ischemic component, because of compression of adjacent brain tissue caused by the tumor 10 , in addition to vasogenic edema commonly described.…”

Section: Discussionsupporting

confidence: 79%

“…Studies have shown correlation between PBE and the expression of certain molecules such as VEGF (vascular endothelial growth factor) and MMF-9 (matrix metalloproteinase-9) 12 . Although significant part of previous studies did not observe correlation between tumor site and the presence of PBE 8,9,11 , some studies have suggested the sphenoid wing as the location most associated with PBE 7 . Results obtained in our study disagree with these data, however.…”

Section: Discussionmentioning

confidence: 88%

“…The presence of PBE in meningiomas is a constant in medical literature [9][10][11][12] . In this series, PBE was found in 70.2% of patients, data that agrees with results of previous studies, which show great variation in the prevalence of PBE.…”

Section: Discussionmentioning

confidence: 99%

“…There are no definite causes yet for the PBE occurrence 6 . Nevertheless, some factors have been associated with their presence, such as the location of the tumor 7 , its size 7 , age 8 and sex of the patient 9 . In this study, we analyzed retrospectively radiographic images of 74 patients undergoing meningioma surgery at Hospital Beneficência Portuguesa de Porto Alegre.…”

mentioning

confidence: 99%

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Peritumoral brain edema in intracranial meningiomas

Pereira-Filho

Soares

Chemale

et al. 2010

Arq. Neuro-Psiquiatr.

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Occurrence of peritumoral brain edema (PBE) in meningiomas has been associated with several factors in recent years, although its pathophysiological mechanism has not yet been fully elucidated. The aim of this study was to analyze the correlation between the presence / degree of PBE and factors such as gender, age, size and histological subtype of tumor. We analyzed the MRI images of 74 patients operated on Hospital Beneficência Portuguesa de Porto Alegre for the presence / degree of PBE and data was statistically correlated with the parameters of the patient. PBE was present in 70.1% of patients. Tumors with higher volume had more PBE. Tumors of the olfactory groove showed more PBE than sphenoid wing and parassagittal tumors. Transitional subtype showed more PBE than fibroblastic and meningothelial subtypes. Key words: brain edema, meningioma, peritumoral brain edema.Edema peritumoral em meningiomas intracranianos rEsumo A presença de edema cerebral peritumoral (ECP) em meningiomas tem sido associada a diversos fatores nos últimos anos, embora o seu mecanismo fisiopatológico ainda não tenha sido inteiramente elucidado. O objetivo desse estudo foi analisar a correlação entre a presença/grau de ECP e fatores como sexo, idade, volume e subtipo histológico do tumor. Foram analisadas imagens de RM de 74 pacientes operados no Hospital Beneficência Portuguesa de Porto Alegre quanto à presença/grau de ECP e os dados correlacionados estatisticamente com os parâmetros do paciente. ECP estava presente em 70,1% dos pacientes. Tumores com maior volume apresentaram mais ECP. Tumores da goteira olfatória apresentaram mais ECP que os da asa do esfenóide e que os parassagitais. Meningiomas transicionais apresentaram mais ECP que os fibroblásticos e que os meningoteliais. Palavras-chave: edema encefálico, meningioma, edema cerebral peritumoral.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Peritumoral brain edema in intracranial meningiomas

Pereira-Filho

Soares

Chemale

et al. 2010

Arq. Neuro-Psiquiatr.

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Statistical analysis of multi-b factor diffusion weighted images can help distinguish between vasogenic and tumor-infiltrated edema

Vandendries

Ducreux

Lacroix

et al. 2013

J. Magn. Reson. Imaging

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Evaluation of Epidemiologic Factors, Radiographic Features, and Pathologic Findings for Predicting Peritumoral Brain Edema in Meningiomas

Sapkota

Yang

Zhu

et al. 2020

Magnetic Resonance Imaging

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BackgroundDespite several treatment options that are available for meningiomas, surgery is the only method currently practiced. Peritumoral brain edema (PTBE) in meningiomas causes difficulty marginalizing the dissection in an intraoperative setting.PurposeTo evaluate whether the epidemiological variables, imaging characteristics, and pathologic parameters are correlated with the presence of PTBE in meningiomas.Study TypeRetrospective study from 2015 to 2018.SubjectsIn all, 550 patients with histopathologically confirmed meningioma were included. After exclusion of patients with extradural, spinal, and intraventricular meningiomas and those with image artifacts, a total of 441 patients were included in the final analysis.Field Strength/SequenceImages were performed with 3T MR scanners and axial/sagittal T1WI, axial/coronal T2WI and axial/sagittal/coronal contrast‐enhanced T1WI after administration of 0.1 mmol/kg of body weight of Gd‐DTPA.AssessmentFourteen variables were patients' age, sex, skull changes, calcification, density, location, margin, volume, cerebrospinal fluid (CSF) cleft, signal intensity (SI) on T2WI, degree and pattern of contrast enhancement, WHO histological classification, and Ki‐67 labeling index.Statistical TestsThe relationship between each factor and the formation of PTBE was examined by multivariate logistic regression analysis.ResultsAfter multivariate logistic regression, the absence of CSF cleft (odds ratio [OR]: 63.43, 95% confidence interval [CI]: 27.24–121.42, P = 1.2 × 10−8), non‐skull base location (OR: 15.32, 95% CI: 5.81–28.23, P = 0.0008), high SI on T2WI (OR: 5.05, 95% CI: 2.27–14.88, P = 0.01), and G I uncommon subtypes (OR: 4.75, 95% CI: 1.42–15.94, P = 0.01) were found to be significant independent factors associated with the occurrence of PTBE in meningiomas. In patients with PTBE‐positive meningiomas, there was no significant correlation between the volume of PTBE and the volume of the tumor (r = 0.17, P = 0.60).Data ConclusionThese factors may be suggestive of anticipating the formation of PTBE.Level of Evidence: 3Technical Efficacy Stage: 3J. Magn. Reson. Imaging 2020;52:174–182.

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Peritumoral brain edema in meningiomas: correlations between magnetic resonance imaging, angiography, and pathology

Cited by 88 publications

References 19 publications

Peritumoral brain edema in intracranial meningiomas

Peritumoral brain edema in intracranial meningiomas

Statistical analysis of multi-b factor diffusion weighted images can help distinguish between vasogenic and tumor-infiltrated edema

Evaluation of Epidemiologic Factors, Radiographic Features, and Pathologic Findings for Predicting Peritumoral Brain Edema in Meningiomas

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