Perivascular adipose tissue: A new possible tissue augmenting coronary vasodilatation in response to acute hypoxia

Abstract

Ralevic, V. 2018. Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulphide and cystathionine -β synthase.

Intermittent hypoxia: Friend and foe

“…Coronary perivascular adipose tissue has been reported to weaken endothelium‐dependent vasodilation by modulating K + channel activity and potentiate coronary artery contraction . Recently, it has been demonstrated that hydrogen sulphide (H 2 S) released from the perivascular adipose tissue augments coronary vasodilation in response to acute hypoxia . These observations extend the previously recognized role of H 2 S as an oxygen sensor and transducer of hypoxia to the myocardial vasculature and move the H 2 S synthesizing enzyme cystathionine β‐synthase (CBS) into focus as a candidate target for the treatment of heart failure …”

Metabolic modelling of kidney diseases: Lessons learned from the liver

“…This generates a latent cellular state of restricted energy production which may suddenly and unexpectedly progress to organ failure if substrate supply is further decreased (eg, because of a temporary heart insufficiency) or an extreme organ performance is demanded (eg, because of high muscle workload, intake of new drugs, long-term starvation or an infectious disease). 2,3 It is necessary to decipher the molecular mechanisms underlying disease-related metabolic changes at the cellular level to understand how malfunctions of tissues, organs and organisms develop. This will also help to develop efficient medical strategies to prevent or delay the disease manifestation and to improve recovery of the affected organ.…”