Perivascular epithelioid cell tumor of the lung: A case report and literature review

Abstract

The perivascular epithelioid cell tumor (PEComa) is a rare tumor of interstitial origin characterized by several immunological and muscle cell markers. The clear cell sugar tumor (CCST) of the lung is a type of PEComa defined by thin cell walls and high levels of glycogen in the cytoplasm. We herein reported the case of a 48-year-old male with a recurrence of lung CCST. The preoperative diagnosis of the lung mass was performed by percutaneous needle biopsy. During the thoracoscopic resection, multiple adhesions in the thoracic cavity were described. The tumor invaded the chest wall, and the boundaries between the tumor and surrounding normal tissues were unclear. The mediastinal lymph nodes were significantly enlarged. No relevant gene mutations were detected. After concomitant chemoradiotherapy, the patient's condition was stable. We also conducted a literature review and discussed the overall findings.

Unlocking Therapeutic Potential: A Comprehensive Exploration of FDA-Approved Sirolimus similars for Perivascular Epithelioid Cell Tumor Treatment through Transcriptomic Insight, Structural Integration, and Drug-Drug Similarity Analysis with Cavity-Guided Blind Docking

“…

Perivascular epithelioid cell tumors pose a significant clinical challenge, necessitating innovative and targeted therapeutic strategies for effective treatment. 1 The conventional paradigm of drug development has been augmented by drug repositioning, particularly leveraging the wealth of knowledge surrounding FDA-approved compounds. Within this context, our research embarks on a comprehensive exploration of the therapeutic potential inherent in FDA-approved Sirolimus analogs for the treatment of PEComas.

…”