Perivascular myoma of myopericytoma and myofibromatosis‐type arising in a chronic scar

Abstract

We describe a case of a cutaneous perivascular myoma with features overlapping between the myofibromatosis and the myopericytoma type. The patient is a 58-year-old woman with a painless plaque-like and multinodular lesion in the pretibial dermis and subcutaneous tissue. She had repeated trauma to this site, first in her early youth that left an area of hyperpigmentation, and then again at age 40. The biopsy showed a biphasic pattern with a myofibromatosis-type component composed of spindle cell myoid nodules and more cellular round cell areas. The myopericytoma-like areas appeared to be infiltrating along vessels. These areas contained aggregates of immature-appearing cells arranged concentrically around vascular lumina in a manner reminiscent of pericytes. Immunohistochemical stains showed focal positivity for smooth muscle actin. Immunohistochemical and ultrastructural studies have showed these pericyte-like cells to be of a myoid origin. The reason for the neoplastic proliferation of perivascular myoid cells is presently unknown. The association of trauma and neoplastic transformation of the skin is rare. We report the first case of a cutaneous perivascular myoma arising in a chronic scar.

Myopericytoma -A Perivascular Myoid Cell Tumor with Review of Literature

“…Progenitor cells for myo pericytes include the myofibroblast or the pericytes both of which exhibit the properties of modified smooth muscle cell [6] . (11)(12)(13)(14)(15)(16)(17) . Male:female ratio found was 1.5:1 and age ranged from 13 to 87 years; with median age of presentation 47 years.…”

Malignant glomus tumor of the foot with obvious neuroendocrine differentiation: a with immunohistochemical studies

“…Myopericytoma usually does not show epithelioid features of tumor cells, and shows nodularities of tumor cells [3][4][5][6][7][8]. Myopericytoma is positive for α-smooth muscle actin [3][4][5][6][7][8].…”

“…The perivascular myoid cell concept has yielded the recognition of myopericytoma [3][4][5][6][7][8], myofibroma [4], myofibromatosis [9], angioleiomyoma [10], and glomus tumors (GTs) [9,11,12], while the perivascular epithelioid cell concept that shows melanocytic lineage has led to the recognition of PEComa [13,14], clear cell sugar tumor [15,16], angiomyolipoma [17], and lymphangiomyomatosis [1]. These tumors belong to a spectrum of perivascular myoid cell tumors and perivascular epithelioid cell tumors, and there are some overlaps among these entities.…”

Myopericytoma of neck region — A case report

“…It is also negative for CD 31, CD 34, S-100 and CK [7]. These tumors have also been reported in chronic scar [8].…”