Perkembangan Konsep Patogenesis Aterosklerosis

Eventyally this study aims to determine the correlation between HDL levels as a risk factor of hypertension. This research used observational analytic design with cross sectional approach. The independent variable was total cholesterol levels and the dependent variable was hypertension. The research was located in Selabangga Village, Moramo District with the total sample of 57 samples based on the inclusion and exclusion criteria selected by the purposive sampling method. These data were obtained by using a measurement instrument of HDL level (lipids Pro) and blood pressure measurement devices (aneroid sphygmomanometer). The result of data was processed by Chi Square statistic test and Prevalence Odds Ratio (POR). The results of HDL research on hypertension found that from the 57 respondents, 34 respondents (56,9%) were hypertension and 25 respondents (43,9%) were hypertension whit HDL level at risk. Based on Chi-square statistical test, it was found that between HDL level and hypertension showed p value of 0.000 <α (0,05). While, the POR value of the HDL variable was 10,000 CI 95% 2,865-34,899. The conclusion of this study was the HDL level correlated as a risk factor for hypertension incidence.

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“…Terbentuknya (15) . HDL membantu menahan proses aterosklerosis, dibentuk pada organ hati dan usus sebelum masuk ke pembuluh darah.…”

Section: Pendahuluanunclassified

Hubungan Kadar High Density Lipoprotein (HDL) Dengan Kejadian Hipertensi

Rafsanjani

Asriati

Kholidha

et al. 2019

JPM

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“…Penggunaan komposisi diet tinggi lemak seperti yang telah diuraikan di atas menyebabkan kelompok tikus yang diberi diet tinggi lemak memiliki kadar kolesterol total lebih tinggi (91,17 mg/dl) bila dibandingkan dengan kelompok diet normal (64,17 mg/dl). Adapun kadar kolesterol total tikus dalam kondisi normal adalah < 74 mg/dl (Lintong, 2009). Perbedaan signifikan antara kelompok diet normal dan diet tinggi lemak dapat disimpulkan bahwa pemberian diet tinggi lemak yang dilakukan dalam penelitian ini dapat meningkatkan kadar kolesterol total tikus secara signifikan.…”

Section: Pembahasanunclassified

Prevention of Increasing Total Cholesterol Level Using Cowpea Yoghurt

Hidayatullah¹

2020

mki

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Atherosclerosis is lipoprotein metabolism disorder which is marked by an increase of total cholesterol level in blood serum. Cowpea contains a lot of isoflavones that can inhibit the activity of the enzyme HMG-CoA reductase in the cholesterologenesis process. The aim of this study is to find out cowpea yogurt which can prevent the increasing total cholesterol level. This study used an experimental study with a post-test only control group design in 30 male rats. It was divided into 5 groups: Results showed that the total cholesterol level among the fifth group was a significant difference (Kruskal-Wallis, p = 0,000). The conclusion of this study is cowpea yogurt can prevent the increasing total cholesterol levels of Wistar rats induced by a high-fat diet.

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“…Adanya radikal bebas akan menyebabkan teroksidasinya LDL yang disebut ox-LDL yang mampu mengaktifkan sel endotel sehingga menghasilkan sitokin proinflamasi dan molekul adhesi yang merangsang infiltrasi monosit dan limfosit T ke daerah intima. (Lintong, 2009;Hansson, 2005). Sitokin akan memicu diferensiasi monosit menjadi makrofag yang akan memfagositosis ox-LDL sehingga membentuk sel busa yang berkontribusi dalam terjadinya plak aterosklerosis (Ingersoll et al, 2011;Francis and Pierce, 2011).…”

Section: Pendahuluanunclassified

Molecular Docking Sianidin dan Peonidin sebagai Antiinflamasi pada Aterosklerosis Secara In Silico

Saputra

2018

jfu

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Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction resulting in plaque growth in the inner walls of the arteries. Endothelial dysfunction causes endothelial activates NF-?B resulting in a transcription of proinflammatory gene supporting the growth of atherosclerotic plaque. The purple sweet potato anthocyanin is a compound known to have activity inhibiting the inflammatory process. The major anthocyanins contained in purple sweetpotato are cyanidine and peonidine. The cyanidine and peonidin activity test was performed as antiinflammatory at atherosclerosis based on their interaction on NF-?B protein using molecular docking method in silico. The stages of this research are preparation of protein structure database of NF-?B, protein preparation using Chimera1.10.1 application, preparation and optimization of cyanidin and peonidin 3D structure using HyperChem8 application, and validation of molecular docking and docking method of cyanidin and peonidin on NF-?B protein using application Autodock4.2. The results showed that cyanidine and peonidine had affinity and formed a hydrogen bond with the NF-?B protein. The bond energy between cyanidine and peonidine with the NF-?B protein is -7.92 kcal/mol and -7.86 kcal/mol which together form the hydrogen bond with the LEU472 amino acid on the binding site equal to the native ligand. Cyanidin and peonidine have the potential of activity as antiatherosklerosis because it has an affinity with the NF-?B protein so that it prevents the inflammatory process in the formation of atherosclerotic plaque.

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Perkembangan Konsep Patogenesis Aterosklerosis

Cited by 7 publications

References 1 publication

Hubungan Kadar High Density Lipoprotein (HDL) Dengan Kejadian Hipertensi

Hubungan Kadar High Density Lipoprotein (HDL) Dengan Kejadian Hipertensi

Prevention of Increasing Total Cholesterol Level Using Cowpea Yoghurt

Molecular Docking Sianidin dan Peonidin sebagai Antiinflamasi pada Aterosklerosis Secara In Silico

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