The Historic District of Panama City was inscribed on the World Heritage List in 1997 for representing an exceptional example of 17th century colonial urban planning in the Americas. This article focuses on the specific analysis of the deteriorated monastic typology, highlighting its historical role as an articulating piece of the original urban layout designed in 1673 after the transfer from Panamá Viejo to the current location and which continues today. Our methodology consisted of reviewing the different stages of each of these buildings, extracting common events, and identifying the examples of the greatest value loss, with the aim of enhancing and highlighting their historical footprint. This study includes approaches from urbanism, architectural history, and heritage preservation that allows us to discuss possible tools, either for protection or adaptative reuse, to avoid the deterioration of such important historical heritage.