Permanenter Hypoparathyreoidismus infolge von Schilddrüsenkarzinomoperationen nach Tschernobyl in der Ukraine

Abstract

Our data partly show a severe form of hypoparathyroidism of very young persons in the Chernobyl region, a finding which strongly supports the need of exact diagnosis and interdisciplinary treatment options of this postoperative disorder.

The Wuerzburg scale: A new classification system for permanent postoperative hypoparathyroidism

“…Our studies show that up to 1=3 of our patients were suffering from this stage of the disease [6,7] in accordance with details from international medical literature [10]. These patients are often asymptomatic or express only mild to untypical clinical symptoms and are subsequently often misdiagnosed in clinical practice.…”

“…This patient collective consisted of victims developing a hypoparathyroidism due to thyroid carcinoma caused by the Chernobyl nuclear accident in 1986 [8,9]. Presently this Institute monitors the largest patient collective of patients with hypoparathyroidism after surgical intervention worldwide (Ukrainian study II) [7].…”

“…These patients suffered from hypoparathyroidism following surgical procedures due to various diseases concerning the parathyroid and thyroid glands (Ukrainian study I) [6]. 3. n ¼ 25 patients of the Endocrinological Institute of the Ukrainian Academy of Sciences in Kiev=Ukraine [7]. This patient collective consisted of victims developing a hypoparathyroidism due to thyroid carcinoma caused by the Chernobyl nuclear accident in 1986 [8,9].…”

Histological and hormonal characteristic of microencapsulated human parathyroid tissue in long-term culture

“…Íàéá³ëüø ñåðéîçíèì óñêëàäíåííÿì ðàäè-êàëüíîãî õ³ðóðã³÷íîãî âòðó÷àííÿ íà ùèòîïî-ä³áí³é àáî ïàðàùèòîïîä³áíèõ çàëîçàõ (ÏÙÇ) º ñòàëèé ï³ñëÿîïåðàö³éíèé ã³ïîïàðàòèðåîç [15], ÿêèé ñóïðîâîäaeóºòüñÿ ñóòòºâèì ïîã³ð-øåííÿì ÿêîñò³ aeèòòÿ ïàö³ºíò³â [3]. Çàì³ñíà òåðàï³ÿ ç âèêîðèñòàííÿì ïàðàòãîðìîíó ëþ-äèíè àáî éîãî ñèíòåòè÷íèõ àíàëîã³â çíàõî-äèòüñÿ íà ñòà䳿 êë³í³÷íîãî âèïðîáóâàííÿ [19], à ñòàíäàðòíå ïðèçíà÷åííÿ ïðåïàðàò³â êàëüö³þ ³ â³òàì³íó D íå çàâaeäè çäàòíå äîñòàòíüî êîìïåíñóâàòè çàõâîðþâàííÿ òà óñêëàäíåííÿ, ùî ïîâÿçàí³ ç ã³ïîïàðàòèðåî-çîì [2].…”

The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia

“…There are single studies that show a significant prevalence of hair loss in patients with hypoparathyroidism. In a study of 25 patients with a symptomatic permanent hypoparathyroidism (following surgery), skin and hair symptoms were estimated to be present in 68% of patients, causing a greater impact on the quality of life than other symptoms related to hypocalcaemia, such as paresthesia, joint pain and osteoporosis [69]. …”