Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#

Ashoor, Jamal Ali; Mohsin, Jinan M.; Mohsin, Hussein Mohammed; Mahde, Basam W.; Gareeb, Mowafaq M.

doi:10.31351/vol30isssuppl.pp16-21

Cited by 4 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This strategy prevents the auto-oxidation of curcumin and provides drug stability during the skin penetration. Besides, olive oil acts as a penetration enhancer as shown in literature [25,38,39]. The suggested mechanism for increased permeation of curcumin can be either disintegrating of the intracellular highly ordered lipid structure by olive oil and co-solvent (methanol) or changing the conformational structure in the intracellular proteins or might be due to increasing the partitioning of curcumin into stratum corneum [38][39][40].…”

Section: Ex-vivo Permeability Study Resultsmentioning

confidence: 99%

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

ERGİN¹,

Inal²,

BARAKAT³

2023

jrp

View full text Add to dashboard Cite

Curcumin has been used in many diseases due to its high therapeutical potential in recent years. Although curcumin is a frequently used natural polyphenolic compound products, its low solubility and poor permeability limits the dermal efficacy of curcumin. Emulgels are a new generation of semi-solid formulations that combine the advantages of both emulsions and gels. The biggest limitation of emulsions is surfactant related irritation problems caused by the use of high amount of surfactants. In this study, it was aimed to increase the skin permeability of curcumin by developing surfactant-free emulgel formulations. In the study, emulgels were developed by Carbopol 940 gels as the aqueous phase, olive oil and curcumin methanol solution as the oil phase. No surfactant was used additionally to show the stabilizing effect of Carbopol in emulgels. The emulgel formulations were subjected to physicochemical characterization by means of organoleptic properties, pH, rheological and mechanical properties. Mechanical properties were carried out by texture profile analyzes to determine the structure related properties such as hardness, compressibility, adhesiveness, cohesiveness and elasticity. The spreadability of the formulations was also determined with Texture Analyzer. Obtained emulgels showed good rheological, mechanical and spreadability properties. The transdermal permeation of the chosen emulgel was studied ex vivo against hydrogel prepared with the same amount of Carbopol. The emulgel formulation significantly increased transdermal permeation compared to the hydrogel. This emulgel formulation successfully passed from stress tests. As a conclusion, the novel surfactant-free emulgel formulation was successfully developed to increase curcumin permeation through the rat skin.

show abstract

Section: Ex-vivo Permeability Study Resultsmentioning

confidence: 99%

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

ERGİN¹,

Inal²,

BARAKAT³

2023

jrp

View full text Add to dashboard Cite

show abstract

“…The receptor compartment of the diffusion cell was filled with a solution of SLS (0.5%, w/v) in phosphatebuffered saline (PBS, PH 7.4) at (32 ±1 °C) to simulate the pH and temperature of the skin. A skin membrane with an effective diffusion surface area (1.76 cm2) was fixed facing upward between the donor and receptor compartments A weight of (5%, w/w) ONDS-loaded invasomes gel equivalent to (8 mg) ONDS was used in the study [41]. Sampling was done every half hour by taking (1 ml) of the receptor solution and compensating with fresh buffer to maintain the sink condition.…”

Section: The Ex Vivo Permeation Studymentioning

confidence: 99%

Preparation, Evaluation, and Histopathological Studies of Ondansetron-Loaded Invasomes Transdermal Gel

SALIH,

MUHAMMED

2024

jrp

View full text Add to dashboard Cite

Ondansetron is a serotonin receptor antagonist for treating nausea and vomiting. Its multiple daily doses and extensive first-pass metabolism faced parenteral and oral administration challenges. The transdermal route enhances its bioavailability as it bypasses the first-pass effect. Invasome vesicles improve the skin permeation of ondansetron via its unique components, lecithin, limonene, and ethanol, which are considered efficient permeation enhancers. The current study intends to develop a gel containing ondansetron as invasomes vesicles with appropriate texture and efficient skin penetration. Two gelling agents, hydroxypropyl methylcellulose K4M and carbopol 934P, were used at two concentrations (0.5 and 1%, w/w). Formulas were evaluated regarding pH, content uniformity, viscosity, spreadability, and ex vivo permeation. The selected formula (F3), which contained ondansetron (5%, w/w) and used carbopol 934P at (0.5%, w/w), was homogeneous, with proper viscosity (21,500 ± 390 mPa.s) at rest and enough spreadability (3.4 ± 0.45 cm). The ex vivo permeation showed permeation flux (Jss) was (280.4 ± 3.5 g/cm2.h) with a shorter lag time (0.5 ± 0.1 h). Characterization studies revealed nanosized vesicles (Dav. = 202.9 ± 0.5 nm) as spherical shapes dispersed within a gel matrix. In vivo, skin irritation and histopathology studies using male Wistar albino rats demonstrated that (F3) was biocompatible, with no irritation reported for six consecutive days. In conclusion, the invasomes gel of ondansetron utilizing carbopol (0.5%, w/w) was prepared for transdermal delivery, offering effective permeation and safe application. An invasomes-loaded gel is considered a novel formulation, giving an efficient and realistic therapeutic option for treating vomiting.

show abstract

“…5 Elimination half-life is 3-10 hours (lower doses), 8-15 hours (higher doses), and MTX average molecular weight of 454.4 Da. 6 MTX usage is restricted due to its limited water solubility, permeability, oral bioavailability, short half-life, and significant side effects.…”

Section: Introductionmentioning

confidence: 99%

“…Micelles, microspheres, nanoparticles, and liposomes are some of the MTX formulations that have been developed to improve MTX bioavailability. 6,7 As a result, the goal of this study is to develop and characterize a MTX (o/w) nanoemulsion to improve MTX solubility as well as permeability resulting in enhanced total bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Formulation and In-vitro Evaluation of Methotrexate Nanoemulsion using Natural Oil

Ashoor¹,

Ghareeb²

2022

IJDDT

View full text Add to dashboard Cite

Objective: The objective of the research was the preparation and evaluation of methotrexate nanoemulsion to improve its solubility, permeability, and bioavailability. Methods: The formulation components were selected based on the solubility study, and the pseudo-ternary phase diagrams were constructed by the aqueous phase titration method. Result and discussion: The prepared nanoemulsions were exposed to several thermodynamic stability studies and then to many characterizations tests for the selection of the best formulation. F 11 is the best formula since it has a 57 nm globule size, 0.21 polydispersity index, +23.67 zeta potential, and 99.57% light transmittance. FTIR study confirmed no incompatibility between drug and excipients. Conclusion: F 11 was a promising nanoemulsion formula that improved methotrexate permeability and bioavailability.

show abstract

Permeability Enhancement of Methotrexate Transdermal Gel using Eucalyptus oil, Peppermint Oil and Olive Oil(Conference Paper )#

Cited by 4 publications

References 3 publications

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel

Preparation, Evaluation, and Histopathological Studies of Ondansetron-Loaded Invasomes Transdermal Gel

Formulation and In-vitro Evaluation of Methotrexate Nanoemulsion using Natural Oil

Contact Info

Product

Resources

About