Permeability of Urea in N-Carboxymethyl Chitosan-Poly (Vynilalcohol) Blend Membranes for Hemodialysis

Abstract

Abstract-A series of membranes are prepared by solvent drying method, which were composed of N-carboxymehtyl chitosan blended with poly(vinyl alcohol) [N-CMC/PVA]. The N-CMC/PVA membranes showed improved strength properties and permeability for low-molecular weight compounds. This novel membranes exhibited good permeability properties for small molecules also indicated a decrease in protein adsorption on the surface of membrane. The structure and the morphology of the resulting membranes were characterized by FTIR. NMR, elementary analysis and scanning electron microscopy (SEM).

Preparation of Citric Acid Crosslinked Chitosan/Poly(Vinyl Alcohol) Blend Membranes for Creatinine Transport

“…The blending between CS.cl.CA and PVA also resulted in the widening of -OH absorption band at 3448 cm -1 . This indicates that the integration of the two materials did not change the type of functional groups in backbone compound, but only increases the percentage of hydroxyl groups [10,14]. The result confirmed the successful crosslinking of citric acid on amine group of chitosan.…”

“…In addition, cyanocobalamin has several C=O groups able to form hydrogen bonds with the the active sites of the membrane. The hydorgen bonds indirectly interfere with the binding process of creatinine by the active sites of the membrane [3,10]. In other words, there is a competition between cyanocobalamin and creatinine when approaching the membrane surface, which is likely to be the cause for the decrease of the transport percentage of creatinine.…”

“…Not all polymers and biopolymers can be used as membrane, as only polymers capable of forming flexible thin layer films and swelling can be used as the base material for membrane synthesis. In order to improve the mechanical strength of the citric acid crosslinked chitosan membrane, in this study we made blends materials with more hydrophilic polymers such as poly(vinyl alcohol) [3,10,14]. This blends membranes were investigated by tensometer, thickness meter, EA and FTIR.…”

Synthesis and Characterization Chitosan-Glutaraldehide Alginate Blends for Candidate Hemodialysis Membrane

“…[9][10] Chitosan membranes have been suggested as a membrane which good solute permeability and mechanical strength. 1 But the functional group chitosan is weak for binding with the compound in blood. Some modified must do to improve physical characteristic and selective of the membrane.…”

“…1 In hemodialysis, blood is filtered through the semipermeable membrane for removing the extra salt and harmful waste. Most polymers used in the preparation of hemodialysis are hydrophobic.…”