Permeability studies of artificial and natural cancellous bone structures

Syahrom, Ardiyansyah; Kadir, Mohammed Rafiq Abdul; Abdullah, Jaafar; Öchsner, Andreas

doi:10.1016/j.medengphy.2012.08.011

Cited by 91 publications

(55 citation statements)

References 69 publications

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“…It is also worth noting that the permeability values encountered in this study ranged from 0.5<K(x10 -8 m 2 )<4.5, which are in agreement to those found in experimental investigation of natural trabecular bone [37,[39][40][41][42][43].…”

Section: Discussionsupporting

confidence: 89%

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Design and properties of 3D scaffolds for bone tissue engineering

Gómez¹,

Vlad

López³

et al. 2016

Acta Biomaterialia

361

199

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Section: Discussionsupporting

confidence: 89%

“…to compare these values to those of natural bone) Permeability versus porosity for some Voronoi scaffold models. (Note:Consider Refs [37,[39][40][41][42][43]. to compare these values to those of natural bone) Specific surface area or bone surface to bone volume (BS/BV) ratio index versus porosity for the studied Voronoi scaffold models.…”

mentioning

confidence: 99%

Design and properties of 3D scaffolds for bone tissue engineering

Gómez¹,

Vlad

López³

et al. 2016

Acta Biomaterialia

361

199

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“…This partly explains the success of acrylic cements despite of the intrinsic presence of unreacted monomer. Flow occurs because of pressure differences due to physiological processes 55 and depends on several factors such as the marrow rheological properties, the permeability of the bone structure, and bone strain. To account for the transport phenomena of marrow within the vertebra, the extracts were diluted 4-fold and 10-fold.…”

Section: Discussionmentioning

confidence: 99%

Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model

López

Mestres

Ott

et al. 2014

Journal of the Mechanical Behavior of Biomedical Materials

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PostprintThis is the accepted version of a paper published in Journal of The Mechanical Behavior of Biomedical Materials. This paper has been peer-reviewed but does not include the final publisher proofcorrections or journal pagination. Citation for the original published paper (version of record):López, A., Mestres, G., Karlsson Ott, M., Engqvist, H., Ferguson, S. et al. (2014) Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acidmodified bone cement in a bovine model. Journal of The Mechanical AbstractAdjacent vertebral fractures are a common complication experienced by osteoporosis patients shortly after vertebroplasty. Whether these fractures are due to the bone cement properties, the cement filling characteristics or to the natural course of the disease is still unclear. However, some data suggests that such fractures might occur because of an imbalance in the load distribution due to a mismatch between the elastic modulus (E) of the bonecement composite, and that of the vertebral cancellous bone. In this study, the properties of bone-compliant linoleic acid-modified bone cements were assessed using a bovine vertebroplasty model. Two groups of specimens (cementonly and bone-cement composites), and four subgroups comprising bone cements with elastic moduli in the range of 870-3500 MPa were tested to failure in uniaxial compression. In addition, monomer release as well as time and concentration-dependent cytocompatibility was assessed through the cement extracts using a Saos-2 cell model.Composites augmented with bone-compliant cements exhibited a reduction in E despite of their relatively high bone volume fraction (BVF). Moreover, a significant positive correlation between the BVF and E for the composites augmented with 870 MPa modulus cements was found. This was attributed to the increased relative contribution of the bone to the mechanical properties of the composites with a decrease in E of the bone cement. The use of linoleic acid reduced monomer conversion resulting in six times more monomer released after 24 hours. However, the cytocompatibility of the bone-compliant cements was comparable to that of the unmodified cements after the extracts were diluted four times. This study represents an important step towards introducing viable bone-compliant bone cements into vertebroplasty practice.

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“…Moreover, tissue engineering scaffolds are expected to provide suitable conditions for cell ingrowth, cell migration, and differentiation (Billström, Blom, Larsson, & Beswick, 2013). It is frequently claimed in the literature that the cell culture state of scaffolds can be well related to the fluid permeability of cellular architecture (Dias, Fernandes, Guedes, & Hollister, 2012;Syahrom, Abdul Kadir, Abdullah, & Öchsner, 2013;Truscello et al, 2012).…”

Section: Introductionmentioning

confidence: 99%