Permeability study of cancellous bone and its idealised structures

Syahrom, Ardiyansyah; Kadir, Mohammed Rafiq Abdul; Harun, M N; Öchsner, Andreas

doi:10.1016/j.medengphy.2014.11.001

Cited by 38 publications

(28 citation statements)

References 63 publications

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“…The values of permeability measured for the samples fabricated in this work are underestimated by three orders of magnitude compared to those measured by Grimm and Williams [31] for the human trabecular bone (0.4-11 × 10 −9 m 2 ) and those experimentally measured by Nauman et al [11] in human vertebral and proximal femur bones, which have a large range of permeability values for human bones (2.68 × 10 −11 -2 × 10 −8 m 2 ). On the other hand, the permeability values are in good agreement with the range measured for the natural cancellous bone (3 × 10 −13 -7.4 × 10 −12 m 2 ) [32], which also has a maximal anisotropy in the permeability (axial/radial) of five times, similar to what was obtained by the radial configuration of layers. This is in agreement with that reported by Nauman et al [11], who pointed out that permeability in human bones can reach high anisotropy in the permeability values, as much 22 times of difference between axial and radial directions.…”

Section: Permeability Evaluationsupporting

confidence: 87%

Processing and Characterization of Bilayer Materials by Solid State Sintering for Orthopedic Applications

Téllez-Martínez

Olmos

Solorio-García

et al. 2021

Metals

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A new processing route is proposed to produce graded porous materials by placing particles of Ti6Al4V with different sizes in different configurations to obtain bilayer samples that can be used as bone implants. The sintering behavior is studied by dilatometry and the effect of the layers’ configuration is established. To determine pore features, SEM and computed microtomography were used. Permeability is evaluated by numerical simulations in the 3D real microstructures and the mechanical properties are evaluated by compression tests. The results show that a graded porosity is obtained as a function of the size of the particle used. The mechanical anisotropy due to the pore size distribution and the sintering kinetics, can be changed by the particle layer arrangements. The Young modulus and yield stress depend on the relative density of the samples and can be roughly predicted by a power law, considering the layers’ configuration on the compression behavior. Permeability is intimately related to the median pore size that leads to anisotropy due to the layers’ configuration with smaller and coarser particles. It is concluded that the proposed processing route can produce materials with specific and graded characteristics, with the radial configuration being the most promising for biomedical applications.

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Section: Permeability Evaluationsupporting

confidence: 87%

Processing and Characterization of Bilayer Materials by Solid State Sintering for Orthopedic Applications

Téllez-Martínez

Olmos

Solorio-García

et al. 2021

Metals

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“…The static mechanical performance of the bone scaffold was evaluated mainly through statics simulation and experiment, and the permeability performance of the bone scaffold was evaluated by fluid dynamic simulation. This study was more comprehensive than the previous study by Syahrom and Wang et al on the cubic scaffold structure [9,10]; Montazeriana et al on the hexagonal and rhombic dodecahedral scaffold structure [12]; and Alaboodi et al on the scaffold with circular aperture [15]. Their researches were more focused on the single compression performance or permeability performance of the scaffold structure, and the experimental results lack a direct comparison with the performance of human tissue.…”

Section: Discussionmentioning

confidence: 95%

“…Metal porous materials, ceramic porous materials, resin porous materials and other porous materials have become the key research objects during the recent years. Syahrom et al proposed body-centered cubic structure, face-centered cubic structure and tetrahedral plate structure [9]. Wang et al designed and prepared body-centered cubic structure of titanium alloy, and studied its mechanical properties [10].…”

Section: Introductionmentioning

confidence: 99%

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Shi

Qin

et al. 2021

PLoS ONE

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In this paper, we take the elliptical pore structure which is similar to the microstructure of cancellous bone as the research object, four groups of bone scaffolds were designed from the perspective of pore size, porosity and pore distribution. The size of the all scaffolds were uniformly designed as 10 × 10 × 12 mm. Four groups of model samples were prepared by selective laser melting (SLM) and Ti6Al4V materials. The statics performance of the scaffolds was comprehensively evaluated by mechanical compression simulation and mechanical compression test, the manufacturing error of the scaffold samples were evaluated by scanning electron microscope (SEM), and the permeability of the scaffolds were predicted and evaluated by simulation analysis of computational fluid dynamics (CFD). The results show that the different distribution of porosity, pore size and pores of the elliptical scaffold have a certain influence on the mechanical properties and permeability of the scaffold, and the reasonable size and angle distribution of the elliptical pore can match the mechanical properties and permeability of the elliptical pore scaffold with human cancellous bone, which has great potential for research and application in the field of artificial bone scaffold.

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“…The Darcy regime corresponds to flow rates situated between 0.007 and 0.08 L/min, where the Reynolds number ranges from 1 to 10. These flow rate values are in the same range as those used for permeability testing of bone or engineered lattice structures in [40,41,52,69], and the fluid velocities (flow Q/area A) are in the same range as those used for fluid flow stimulation of bone cells [70]. The permeabilities of the manufactured structures corresponding to the Darcy regime region are plotted in Figure 11.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the permeability of bones to fluids, which ensures an adequate nutrient supply to surrounding tissues, average values reported in the literature for vertebrae vary from 0.49 to 44.5 × 10 −9 m 2 , depending on the sample selection and preparation [39][40][41]. In these sources, the absolute permeability k is calculated using Darcy's law by measuring the pressure drop and fluid velocity through a bone sample (Equation ( 5)).…”

Section: Functional Requirements To Intervertebral Cagesmentioning

confidence: 99%

Mechanical properties and fluid permeability of gyroid and diamond lattice structures for intervertebral devices: functional requirements and comparative analysis

Timercan

Sheremetyev

Braïlovski

2021

Science and Technology of Advanced Materials

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Current intervertebral fusion devices present multiple complication risks such as a lack of fixation, device migration and subsidence. An emerging solution to these problems is the use of additively manufactured lattice structures that are mechanically compliant and permeable to fluids, thus promoting osseointegration and reducing complication risks. Strut-based diamond and sheet-based gyroid lattice configurations having a pore diameter of 750 µm and levels of porosity of 60, 70 and 80% are designed and manufactured from Ti-6Al-4V alloy using laser powder bed fusion. The resulting structures are CT–scanned, compression tested and subjected to fluid permeability evaluation. The stiffness of both structures (1.9–4.8 GPa) is comparable to that of bone, while their mechanical resistance (52–160 MPa) is greater than that of vertebrae (3–6 MPa), thus decreasing the risks of wither bone or implant failure. The fluid permeability (5–57 × 10 −9 m 2 ) and surface-to-volume ratios (~3) of both lattice structures are close to those of vertebrae. This study shows that both types of lattice structures can be produced to suit the application specifications within certain limits imposed by physical and equipment-related constraints, providing potential solutions for reducing the complication rate of spinal devices by offering a better fixation through osseointegration.

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Permeability study of cancellous bone and its idealised structures

Cited by 38 publications

References 63 publications

Processing and Characterization of Bilayer Materials by Solid State Sintering for Orthopedic Applications

Processing and Characterization of Bilayer Materials by Solid State Sintering for Orthopedic Applications

Study on mechanical properties and permeability of elliptical porous scaffold based on the SLM manufactured medical Ti6Al4V

Mechanical properties and fluid permeability of gyroid and diamond lattice structures for intervertebral devices: functional requirements and comparative analysis

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