Permethrin modulates cholinergic mini-synaptic currents by partially blocking the calcium channel

Yan, Ying; Yang, Ying; You, Jing; Yang, Guangxin; Xu, Ye; Huang, Naya; Wang, Xutian; Ran, Dongzhi; Yuan, Xi; Ying, Jin; Fan, Yuting; Lei, Jiayao; Li, Weicong; Gu, Huaiyu

doi:10.1016/j.toxlet.2011.01.009

Cited by 19 publications

(11 citation statements)

References 30 publications

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“…Application of pesticides decreases the urease activity in the soil which is beneficial for plants by reducing the hydrolysis of urea because it helps to maintain nitrogen availability to plant (Antonious 2003). On the other hand, the fungicides validamycin and Car enhanced urease activity, respectively, up to 13-21% and to 70% (Qian et al 2007, Yan et al 2011. In our experiment, we found inhibited urease activity by Gly and Imi whereas stimulated with Car.…”

Section: Discussionsupporting

confidence: 49%

“…Acid phosphatase activity was observed highly inhibited immediately after Car addition compared to the control (Tortella et al 2013). Researchers also found that other fungicides either had inhibited phosphatases activity or no effect (Bello et al 2008, Yan et al 2011. On the application of herbicides the activity of acid and alkaline phosphatase is either stimulated (imazethapyr) or unchanged (aurora 40 WG and rimsulfuron) (Perucci et al 2000, Baćmaga et al 2012.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have proven that herbicides and fungicides appear to have no effect (Cycon et al 2010, Yan et al 2011, Baćmaga et al 2012 or reduced effect on the activity of urease (Sukul 2006, Caceres et al 2009, Tejada 2011. Application of pesticides decreases the urease activity in the soil which is beneficial for plants by reducing the hydrolysis of urea because it helps to maintain nitrogen availability to plant (Antonious 2003).…”

Section: Discussionmentioning

confidence: 99%

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Pseudomonas putida and Bacillus amyloliquefaciens alleviates the adverse effect of pesticides and poise soil enzymes activities in chickpea (Cicer arietinum L.) rhizosphere

Kumar¹,

Yusuf²,

Chauhan³

et al. 2017

Trop. Plant Res.

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Abstract:Pesticide application for disease management is a major action for crop protection from last seven decades. The repeated application of pesticide is the most important cause of the reduction in microbial population. Soil microorganisms play an important role in efficient acquisition and transportation of nutrients to plant. Pesticides leached in soil disturb the activities of soil enzymes, such as β-glucosidase, dehydrogenase, phosphatases, protease and urease secreted by these microorganisms. This drastically reduces nutrient availability to the plants and soil fertility. In vitro experimental studies revealed that our PGPR (Pseudomonas putida and Bacillus amyloliquefaciens) have the ability to tolerate pesticides at concentrations such as Carbendazim (0.512%), Imidacloprid (3.27%) and Glyphosate (3.27%). We have observed an increase in PGP activities like IAA production, exopolysachchride production, biofilm synthesis, phosphate solubilization and siderophore production on the addition of pesticides at concentrations below there threshold values, on the contrary reduction in activities was noticed above these values. Soil enzymes activities from chickpea rhizosphere without PGPR inoculation showed variability on the application of pesticides whereas activities were found normal or increased with PGPR inoculation and pesticides application. Thus PGPR remains panacea for soils by managing adverse effects of pesticide application. Hence our results concluded that P. putida and B. amyloliquefaciens have the ability to reduce the negative impact of three pesticides and poise soil enzymes activities. Hence our PGPR acts as efficient biofertilizers to improve soil fertility and soil health.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pseudomonas putida and Bacillus amyloliquefaciens alleviates the adverse effect of pesticides and poise soil enzymes activities in chickpea (Cicer arietinum L.) rhizosphere

Kumar¹,

Yusuf²,

Chauhan³

et al. 2017

Trop. Plant Res.

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“…Voltage-clamp recordings were performed using borosilicate glass electrodes (B150-86-10; Sutter Instrument Co., Novato, CA, USA) as previously described (24). Gigaohm seals were achieved prior to recording the on-cell configuration, followed by the whole-cell configuration, whilst in the voltage-clamp mode.…”

Section: Drosophila Strainsmentioning

confidence: 99%

Effects of sevoflurane on leucine-rich repeat kinaseï¿½2-associated Drosophila model of Parkinson's disease

et al. 2014

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Abstract.Patients with Parkinson's disease (PD) often require surgery, and therefore may receive inhalation anesthesia. However, it is currently unknown whether inhalation anesthetics affect the prognosis of the disease. Leucine-rich repeat kinase 2 (LRRK2) genetic mutations are the most common cause of familial PD, contributing to ~39% of all cases in certain populations. The aim of the present study was to determine the effects of inhaled anesthetics on PD, by observing the influence of sevoflurane on a LRRK2-associated Drosophila model of PD. PD transgenic Drosophila overexpressing LRRK2 were generated by crossing flies expressing an LRRK2 upstream activation sequence, with tyrosine hydroxylase (TH)-Gal4 flies. Western blot analysis successfully verified that the transgenic Drosophila overexpressed LRRK2. Three days prior to eclosion, three genotypes of Drosophila were divided into four groups, and were exposed to air, 1, 2, or 3% sevoflurane, for 5 hours. Twenty-four hours after the exposure, the electrophysiological activities of the projection neurons (PN) in the brains of the Drosophila were recorded using a patch clamp. The locomotor activities were tested on days 5,10,15,20, 25,30,35 and 40 following eclosion. The frequency of miniature excitatory synaptic currents (mEPSCs) obtained from the PNs of the TH-wild type LRRK2 (TH-WT) Drosophila brain, following exposure to air (1.60±0.05 Hz), was lower as compared with the wild type LRRK2 (WT) (2.51±0.07 Hz) and W1118 (2.41±0.10 Hz) Drosophila. After exposure to 1, 2 and 3% sevoflurane, the frequency of mEPSCs in the brains of the TH-WT group decreased to 0.82±0.04 Hz, 0.63±0.16 Hz and 0.55±0.04 Hz, respectively. The percentage decrease of the frequency of mEPSCs, from exposure to air to 1% sevoflurane, of the TH-WT group (48.32%±3.08%) was significantly higher, as compared with the WT (39.17%±1.42%) and W1118 (35.10%±2.66%) groups, and there was no statistical difference between the WT and W1118 groups. The transgenic TH-WT Drosophila presented an early decrease in locomotor ability, as compared with the WT and W1118 groups. Following a 5 hour exposure to sevoflurane, the percentage decrease of the climbing abilities of the TH-WT group, from exposure to air to 1% sevoflurane, were significantly lower, as compared with the WT and W1118 groups. In conclusion, sevoflurane had negative effects on the control W1118 flies, and also severely aggravated the prognosis of PD in the LRRK2-associated Drosophila model, through synaptic cholinergic deficits and impairment on locomotor abilities.

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“…Meanwhile, the MOA of cypermethrin has been shown to cause a depolarization of the Na þ channel [37,38]. Recent work [39,40] has also proposed that additional toxic mechanisms of pyrethroids may exist. Studies have suggested that pyrethroids may act on calcium and chloride channels and affect modulating cholinergic mini-synaptic currents.…”

Section: Antagonistic Joint Toxicity Of Cypermethrin and Leadmentioning

confidence: 99%

Joint toxicity of a pyrethroid insecticide, cypermethrin, and a heavy metal, lead, to the benthic invertebrate Chironomus dilutus

Mehler

Lydy

et al. 2011

Enviro Toxic and Chemistry

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Abstract-Insecticides and heavy metals are frequently detected in the environment, but few studies have assessed the joint toxicity of organic and inorganic contaminants. Joint toxicity of a pyrethroid insecticide, cypermethrin, and a heavy metal, Pb 2þ , was evaluated in the present study. An antagonistic toxic response was observed when the benthic invertebrate Chironomus dilutus was simultaneously exposed to the two contaminants in both water and sediment exposures. Pre-exposure bioassays with midges were also conducted, and toxicity of cypermethrin was significantly reduced for midges that were pre-exposed to Pb 2þ . In addition, the impact of Pb 2þ on the bioavailability of cypermethrin to midges was measured using Tenax extraction. No significant difference was noted in the amount of Tenax-extractable cypermethrin when different amounts of Pb 2þ were added to sediment. Results suggested that altered organism sensitivity may contribute to the observed antagonistic interaction between cypermethrin and Pb 2þ

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Permethrin modulates cholinergic mini-synaptic currents by partially blocking the calcium channel

Cited by 19 publications

References 30 publications

Pseudomonas putida and Bacillus amyloliquefaciens alleviates the adverse effect of pesticides and poise soil enzymes activities in chickpea (Cicer arietinum L.) rhizosphere

Pseudomonas putida and Bacillus amyloliquefaciens alleviates the adverse effect of pesticides and poise soil enzymes activities in chickpea (Cicer arietinum L.) rhizosphere

Effects of sevoflurane on leucine-rich repeat kinaseï¿½2-associated Drosophila model of Parkinson's disease

Joint toxicity of a pyrethroid insecticide, cypermethrin, and a heavy metal, lead, to the benthic invertebrate Chironomus dilutus

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