Permethrin-Resistant Human Head Lice, Pediculus capitis, and Their Treatment

Yoon, Kyong Sup; Gao, Jianrong; Lee, Si Hyeock; Clark, J. Marshall; Brown, Leon; Taplin, David

doi:10.1001/archderm.139.8.994

Cited by 112 publications

(73 citation statements)

References 24 publications

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“…8,30 An alternate treatment schedule on days 0, 7, and 13 to 15 has been proposed for nonovicidal products. 31 Resistance to 1% permethrin has been reported, 8,[32][33][34][35] but the prevalence of this resistance is not known. .…”

Section: Permethrin (1%)mentioning

confidence: 99%

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Head Lice

Frankowski¹,

Bocchini²

2010

Pediatrics

107

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Head lice infestation is associated with limited morbidity but causes a high level of anxiety among parents of school-aged children. Since the 2002 clinical report on head lice was published by the American Academy of Pediatrics, patterns of resistance to products available overthe-counter and by prescription have changed, and additional mechanical means of removing head lice have been explored. This revised clinical report clarifies current diagnosis and treatment protocols and provides guidance for the management of children with head lice in the school setting.

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Section: Permethrin (1%)mentioning

confidence: 99%

“…Assessment of the severity of the infestation, the number of recurrences, the local levels of resistance to available pediculicides, and the potential for transmission are also critical when recommending newer products. 35 …”

Section: New Productsmentioning

confidence: 99%

Head Lice

Frankowski¹,

Bocchini²

2010

Pediatrics

107

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“…Over the last two decades, resistance to pyrethrins and pyrethroid insecticides by the human head louse, Pediculus humanus capitis, has been widely documented (Burgess et al, 1995;Downs et al, 1999a;Downs et al, 1999b;Chosidow et al, 1994;Mumcuoglu et al, 1995;Hemingway et al, 1999;Rupes et al, 1995;Picollo et al, 1998;Vassena et al, 2003;Yoon et al, 2003;Yoon et al, 2004;Lee et al, 2000b). Heightened public and governmental concerns have occurred because of increased incidents of head louse infestations among school children (http://www.cdc.gov/ncidod/dpd/parasites/lice/default.htm; http://www.headlice.org).…”

Section: Introductionmentioning

confidence: 99%

Three mutations identified in the voltage-sensitive sodium channel α-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes

SupYoon

Symington

Lee

et al. 2008

Insect Biochemistry and Molecular Biology

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Point mutations in the para-orthologous sodium channel α-subunit of the head louse (M815I, T917I and L920F) are associated with permethrin-and DDT-resistance. These mutations were inserted in all combinations using site-directed mutagenesis at the corresponding amino acid sequence positions (M827I, T929I and L932F) of the house fly para-orthologous voltage-sensitive sodium channel α-subunit (Vssc1 WT ) gene and heterologously co-expressed with the sodium channel auxiliary subunit of house fly (Vsscβ) in Xenopus oocytes. The double mutant possessing M827I and T929I (Vssc1 MITI /Vsscβ) caused a ~4.0 mV hyperpolarizing shift and the triple mutant, Vssc1 MITILF / Vsscβ, caused a ~3.2 mV depolarizing shift in the voltage dependence of activation curves. Vssc1 MITI /Vsscβ, Vssc1 TILF /Vsscβ and Vssc1 MITILF /Vsscβ caused depolarizing shifts (~6.6, ~7.6 and ~8.8 mV, respectively) in the voltage dependence of steady-state inactivation curves. The M827I and L932F mutations reduced permethrin sensitivity when expressed alone but the T929I mutation, either alone or in combination, virtually abolished permethrin sensitivity. Thus, the T929I mutation is the principal cause of permethrin resistance in head lice. Comparison of the expression rates of channels containing single, double and triple mutations with that of Vssc1 WT /Vsscβ channels indicates that the M827I mutation may play a role in rescuing the decreased expression of channels containing T929I.

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“…Pediculosis pubis is usually transmitted by sexual contact (849). Reported resistance to pediculcides (permethrin and pyrethrins) has been increasing and is widespread (850,851). Malathion can be used when treatment failure is believed to have occurred as a result of resistance.…”

Section: Ectoparasitic Infections Pediculosis Pubismentioning

confidence: 99%

Sexually Transmitted Diseases Treatment Guidelines 2002

2002

PsycEXTRA Dataset

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SummaryThese guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (STDs) were updated by CDC after consultation with a group of professionals knowledgeable in the field of STDs who met in Atlanta on April 30-May 2, 2013. The information in this report updates the Sexually Transmitted Diseases Treatment Guidelines, 2010 (MMWR Recomm Rep 201059 [No. RR-12]). These updated guidelines discuss 1) alternative treatment regimens for Neisseria gonorrhoeae; 2) the use of nucleic acid amplification tests for the diagnosis of trichomoniasis; 3) alternative treatment options for genital warts; 4) the role of Mycoplasma genitalium in urethritis/cervicitis and treatment-related implications; 5) updated HPV vaccine recommendations and counseling messages; 6) the management of persons who are transgender; 7) annual testing for hepatitis C in persons with HIV infection; 8) updated recommendations for diagnostic evaluation of urethritis; and 9) retesting to detect repeat infection. Physicians and other health-care providers can use these guidelines to assist in the prevention and treatment of STDs.

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Permethrin-Resistant Human Head Lice, Pediculus capitis, and Their Treatment

Cited by 112 publications

References 24 publications

Head Lice

Head Lice

Three mutations identified in the voltage-sensitive sodium channel α-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes

Sexually Transmitted Diseases Treatment Guidelines 2002

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