Permethrin

Swaine, Harry; TANDY, M.J.

doi:10.1016/b978-0-12-784313-1.50013-4

Cited by 3 publications

(2 citation statements)

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“…Permethrin, a broad-spectrum synthetic pyrethroid insecticide registered with the U.S. Environmental Protection Agency (EPA), was first synthesized in 1973 and first marketed in 1977 (Swaine and Tandy 1984). Permethrin was first registered and tolerances were established in the United States in 1979 (U.S.…”

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confidence: 99%

Cancer Incidence among Pesticide Applicators Exposed to Permethrin in the Agricultural Health Study

Rusiecki

Patel

Koutros

et al. 2009

Environ Health Perspect

102

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BackgroundPermethrin is a synthetic pyrethroid insecticide widely used in agriculture, in public health, and in many U.S. homes and gardens.ObjectiveIn this study we evaluated the incidence of cancer among pesticide applicators exposed to permethrin in the Agricultural Health Study (AHS).MethodsA total of 49,093 pesticide applicators were included in this analysis of the AHS, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered questionnaires completed in 1993–1997. Average length of follow-up since applicator enrollment in the cohort was 9.14 years. We used two permethrin exposure metrics: a) lifetime days applicators personally mixed or applied permethrin and b) intensity-weighted lifetime days (lifetime days weighted by estimated intensity of exposure). We used Poisson regression analysis to estimate relative risks (RRs) and 95% confidence intervals (CIs) for malignancies by tertiles of exposure.ResultsWe found no associations between permethrin and all malignant neoplasms combined, or between permethrin and melanoma, non-Hodgkin lymphoma, leukemia, or cancers of the colon, rectum, lung, or prostate. We found elevated and statistically significant risks for multiple myeloma in the highest tertiles of both lifetime exposure-days (RR = 5.72; 95% CI, 2.76–11.87) and intensity-weighted lifetime exposure-days (RR = 5.01; 95% CI, 2.41–10.42), compared with applicators reporting they never used permethrin; these results are based on only 15 exposed cases. These findings were similar across a variety of alternative exposure metrics, exposure categories, and reference groups.ConclusionsThis study found no association with most cancers analyzed. Although the suggested association with multiple myeloma was based on a small number of cases, it warrants further evaluation.

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confidence: 99%

Cancer Incidence among Pesticide Applicators Exposed to Permethrin in the Agricultural Health Study

Rusiecki

Patel

Koutros

et al. 2009

Environ Health Perspect

102

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“…Thus, the inactive impurities can be incorporated into the determination of the active ingredient, and would require separate determination of the isomer ratios. 12 In LC, the composition of the mobile phase is of prime importance in the separation. 13 Although changes in the column stationary phases can enable the separation of geometrical isomers, this approach is not always successful even when using capillary columns.…”

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confidence: 99%