Peroxidase as a marker for oestrogen dependence in human breast cancer

Collings, J R; Savage, Nerina

doi:10.1038/bjc.1979.208

Cited by 11 publications

(1 citation statement)

References 7 publications

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“…Although its physiological role is unclear, it has been suggested to be involved in oestrogen metabolism (Klebanoff, 1965;Br6kelmann, 1969;Lyttle & Jellinck, 1972). More recently, several attempts have been made to use this oestrogen-induced activity as marker for tissues where growth is regulated by the hormone, but such studies have led to conflicting results (Anderson et al, 1975;Strum & Becci, 1979;Collings & Savage, 1979;Penney et al, 1980;Brightwell et al, 1981;Levy et al, 1981;Duffy & O'Connell, 1981;Holt et al, 1981;King et al, 1981). Uterine peroxidase activity can be fractionated into two very similar enzyme activities with different electrophoretic mobilities and molecular weights (peroxidase I, Mr 90000; peroxidase II, M, 40000) (Olsen & Little, 1979).…”

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Comparative studies on oestrogen-induced rat uterus peroxidase and rat eosinophil peroxidase

Olsen

Little

1982

Biochemical Journal

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Rat eosinophil peroxidase and rat uterine peroxidase II showed similar electrophoretic mobilities, molecular weights, specific activities and spectral properties and could be purified by essentially identical techniques. Antibodies raised against the uterine enzyme strongly inhibited the eosinophil enzyme. It is suggested that rat eosinophil peroxidase and rat uterine peroxidase II may well be one and the same enzyme.

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