Peroxiredoxin 5: Structure, Mechanism, and Function of the Mammalian Atypical 2-Cys Peroxiredoxin

Knoops, Bernard; Goemaere, Julie; Eecken, Valérie Van der; Declercq, Jean‐Paul

doi:10.1089/ars.2010.3584

Cited by 212 publications

(179 citation statements)

References 101 publications

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“…To test this, Sabharwal et al (79) reasoned that the expression of an enzymatic scavenger of H 2 O 2 exclusively in the mitochondrial IMS should abolish functional responses to hypoxia by preventing ROS released from complex III to reach the cytosol. Peroxiredoxin-5 (PRDX5) is an atypical 2-cysteine-containing peroxidase that is normally expressed in multiple subcellular compartments including the mitochondrial matrix (45). This enzyme functions as a monomer, whereas other H 2 O 2 scavengers only function as multimers.…”

Section: Mitochondrial Oxygen Sensingmentioning

confidence: 99%

Mitochondria in lung biology and pathology: more than just a powerhouse

Schumacker

Gillespie

Nakahira

et al. 2014

American Journal of Physiology-Lung Cellular and Molecular Phys

165

164

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An explosion of new information about mitochondria reveals that their importance extends well beyond their time-honored function as the “powerhouse of the cell.” In this Perspectives article, we summarize new evidence showing that mitochondria are at the center of a reactive oxygen species (ROS)-dependent pathway governing the response to hypoxia and to mitochondrial quality control. The potential role of the mitochondrial genome as a sentinel molecule governing cytotoxic responses of lung cells to ROS stress also is highlighted. Additional attention is devoted to the fate of damaged mitochondrial DNA relative to its involvement as a damage-associated molecular pattern driving adverse lung and systemic cell responses in severe illness or trauma. Finally, emerging strategies for replenishing normal populations of mitochondria after damage, either through promotion of mitochondrial biogenesis or via mitochondrial transfer, are discussed.

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Section: Mitochondrial Oxygen Sensingmentioning

confidence: 99%

Mitochondria in lung biology and pathology: more than just a powerhouse

Schumacker

Gillespie

Nakahira

et al. 2014

American Journal of Physiology-Lung Cellular and Molecular Phys

165

164

View full text Add to dashboard Cite

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“…7). Different Prxs are differentially susceptible to overoxidation; for example, Prx2 is more easily overoxidized compared to Prx1 or Prx3 (108), while Prx5 is relatively resistant (48 …”

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confidence: 99%

Involvement of Redox State in the Aging ofDrosophila melanogaster

Orr

Radyuk

Sohal

2013

Antioxidants & Redox Signaling

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Significance: The main objective of this review was to provide an exposition of investigations, conducted in Drosophila melanogaster, on the role of reactive oxygen species and redox state in the aging process. While early transgenic studies did not clearly support the validity of the oxidative stress hypothesis of aging, predicated on the accumulation of structural damage, they spawned a broader search for redox-related effects that might impact the aging process. Recent Advances: Initial evidence implicating the thiol redox state as a possible causative factor in aging has been obtained in Drosophila. Overexpression of genes, such as GCL, G6PD, Prx2, and Prx5, which are involved in the maintenance of thiol redox homeostasis, has strong positive effects on longevity. Further, the depletion of peroxiredoxin activity in the mitochondria through the double knockdown of Prx5 and Prx3 not only results in a redox crisis but also elicits a rapid aging phenotype. Critical Issues: Herein, we summarize the present status of knowledge about the main components of the machinery controlling thiol redox homeostasis and describe how age-related redox fluctuations might impact aging more acutely through disruption of the redox-sensitive signaling mechanisms rather than via the simple accumulation of structural damage. Future Directions: Based on these initial insights into the plausible impact of redox fluctuations on redox signaling, future studies should focus on the pathways that have been explicitly implicated in aging, such as insulin signaling, TOR, and JNK/FOXO, with particular attention to elements that are redox sensitive. Antioxid. Redox Signal. 19, 788-803. Historical BackgroundLinkage between energy utilization and life span S tudies in the fruit fly, Drosophila melanogaster, have historically made important contributions toward the development of basic concepts in many areas of biology, including the aging process, especially in defining the role of oxygen metabolism in the determination of life span. In 1917, Loeb and Northrop showed that the life span of D. melanogaster is inversely associated with the ambient temperature (61), which, in turn, was later demonstrated to be linked to the rate of oxygen consumption within the physiological range, whose upper limit for long-term survival and optimal fecundity is *27°C (67). A major advance in the field of aging that can be largely credited to the Drosophila model was Pearl's (77) interpretation of the effects of temperature on longevity, namely, shorter life spans at elevated temperatures are ascribable to a relatively higher physical activity or the rate of living (ROL). As originally proposed, the length of life of an individual organism is governed by two distinct factors: (i) a genetically determined metabolic potential, that is, the total amount of energy consumed during life, which varies in different genotypes, and (ii) the rate at which this metabolic potential is expended by the individual or the rate of its metabolism. It is a widely recognized phe...

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“…Six mammalian Prx isoforms (Prx I-VI) have been identified to date and can be divided into three subgroups: typical 2-Cys (Prx I-IV), atypical 2-Cys (Prx V), and 1-Cys (Prx VI) subgroups (1)(2)(3). The 2-Cys Prx enzymes exist as homodimers and possess two conserved Cys residues.…”

mentioning

confidence: 99%