Peroxisome proliferator-activated receptor gamma expression in peripheral blood mononuclear cells and angiopoietin-like protein 4 levels in obese children and adolescents

Sadeghabadi, Zahra Arab; Nourbakhsh, Mitra; Alaee, Mohammad Reza; Larijani, Bagher; Razzaghy-Azar, Maryam

doi:10.1007/s40618-017-0730-y

Cited by 24 publications

(18 citation statements)

References 56 publications

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“…Only one study focused on the pediatric age group has shown that circulating ANGPTL-4 levels are significantly lower in children and adolescents with obesity and positively correlated with peroxisome proliferator-activated receptor expression in peripheral blood mononuclear cells [32]. Accordingly, the present work shows a decrease in ANGPTL-4 levels in children and adolescents with obesity independent of the gender and pubertal stage.…”

Section: Discussionsupporting

confidence: 55%

ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents

et al. 2019

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Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3–17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5–18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.

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Section: Discussionsupporting

confidence: 55%

ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents

et al. 2019

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“…Likewise, studies on mice with induced obesity, exhibited reduced expression of PPARα and carnitine palmitoyltransferase I (CPT-1) in the liver [ 38 ]. PPARγ expression is also reduced in PBMC from obese children and adolescents [ 39 ]. Indeed, obese mice treated with bezafibrate (BZ), an agonist that preferentially activates PPARα and PPARγ, improves biochemical parameters and reduce the WAT proinflammatory state in obese mice [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population

et al. 2020

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Background Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic components triggered by pediatric obesity is a common but scarcely understood aspect of the disease. Peroxisome proliferator-activated receptors (PPARs) are a group of transcription factors essential for energy and immune homeostasis of different tissues. Besides, the glucagon-like peptide-1 receptor (GLP-1R) activation influences insulin secretion, but also regulates the cytokine profile possibly mediated through a PPAR isotype. However, the role of PPARs and GLP-1R in leukocytes from obese pediatric patients remains unclear. Therefore, we examined the expression of PPARs isotypes and GLP-1R in leukocytes, and its correlation with metabolic, hormonal, inflammatory, and anthropometric markers in an obese pediatric population. Results Obese children and adolescents presented a significant increase in anthropometric and body composition parameters, TG, VLDL, TG/HDL, android fat (%)/gynoid fat (%) (A/G%) index, and HOMA score when compared with the control group. Obese participants exhibited a pro-inflammatory profile with an augment of IL-8 (p = 0,0081), IL-6 (p = 0,0005), TNF-α (p = 0,0004), IFN-γ (p = 0,0110), MCP-1 (p = 0,0452), and adipsin (p = 0,0397), whereas displayed a reduction of adiponectin (p = 0,0452). The expression of PPARα and GLP-1R was lower in the leukocytes from obese participants than in lean subjects. Furthermore, PPARα correlates negatively with TNF-α (p = 0,0383), while GLP-1R did not show correlation with any inflammatory variable. However, both receptors correlate negatively with the abdominal skinfold. Although PPARβ/δ expression was similar between groups, it was negatively associated with IL-8 levels (p = 0,0085). Conclusions PPARα and PPARβ/δ expression are negatively correlated with the proinflammatory markers TNF-α and IL-8, respectively, suggesting participation in the regulation of inflammation which was observed to be altered in pediatric obesity. Furthermore, PPARα and GLP-1R are downregulated in leukocytes from obese participants. The low expression of both receptors is correlated with an increase in abdominal skinfold, suggesting a role in fat distribution that could indirectly affect cytokine secretion from different immune and adipose cells, likely triggering an inflammatory profile as a consequence of obesity. Altogether, these findings may impact the understanding and implementation of PPARα or GLP-1R agonists in the clinic.

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“…PPAR gene is the one of the PPARs subtypes that is by far the most widely studied. It is not only the target molecular of Thiazolane diketones but also an important regulatory factor of adipocyte differentiation and fat endocrine functions of the important regulatory factor [5]. Moreover, PPAR gene acted as a signal transfer regulator between gene expression of adipocytes and adipogenesis and insulin-producing cells.…”

Section: Introductionmentioning

confidence: 99%

Association between peroxisome proliferator-activated receptor γ-2 gene Pro12Ala polymorphisms and risk of hypertension: an updated meta-analysis

Zhang

Li³

et al. 2019

Bioscience Reports

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Previous studies investigate the relationship between peroxisome proliferator-activated receptor γ-2 (PPAR) gene Pro12Ala polymorphisms and risk of hypertension. However, the number of available studies was extremely limited. We updated this evidence and gave more significant results. We performed comprehensive computer-based searches in the PubMed, Web of Science, Embase, Google Scholar, the Cochrane library, Wanfang database, China National Knowledge Infrastructure, and China Biological Medicine Database. All studies that reported the association between the PPARγ2Pro12Ala polymorphisms and hypertension were identified. Twenty-one studies were finally included in the present study. In the domain model, the PPARγ1Pro12Ala polymorphism was not associated with hypertension (odds ratio (OR) = 0.85, 95% confidence interval (CI): 0.71–1.03, P=0.108). The significant relationship was found in the recessive model (OR = 0.67, 95% CI: 0.53–0.85), in the additive model (OR = 0.61, 95% CI: 0.48–0.77), and in the allele genetic model (OR = 0.81, 95% CI: 0.66–0.99). Subgroup analysis indicated that the PPARγ1Pro12Ala polymorphism from the all gene models was also not related to the risk of hypertension in Caucasians. In Asians, however, the results (P=0.002; I2 = 57.6%) suggested a significant relationship between PPARγ1Pro12Ala and hypertension in the domain model (OR = 0.80, 95% CI: 0.65–0.99), in the recessive model (OR = 0.57, 95% CI: 0.44–0.75), in the additive model (OR = 0.51, 95% CI: 0.39–0.66), and in the allele model (OR = 0.75, 95% CI: 0.60–0.94). The PPARγ1Pro12Ala polymorphism could affect the risk of primary hypertension amongst Asians. The A allele gene was a protective genotype for primary hypertension. The PPARγ1Pro12Ala polymorphism was not associated with hypertension amongst Caucasians.

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Peroxisome proliferator-activated receptor gamma expression in peripheral blood mononuclear cells and angiopoietin-like protein 4 levels in obese children and adolescents

Abstract: PPARγ is decreased in childhood obesity and may be responsible for diminished ANGPTL4 levels.

Cited by 24 publications

References 56 publications

ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents

ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents

PPARα and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population

Association between peroxisome proliferator-activated receptor γ-2 gene Pro12Ala polymorphisms and risk of hypertension: an updated meta-analysis

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