2010
DOI: 10.1016/j.steroids.2009.10.012
|View full text |Cite
|
Sign up to set email alerts
|

Peroxisome proliferator-activated receptor gamma (PPARγ): Is the genomic activity the only answer?

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
74
0
3

Year Published

2012
2012
2019
2019

Publication Types

Select...
6
3
1

Relationship

0
10

Authors

Journals

citations
Cited by 87 publications
(79 citation statements)
references
References 88 publications
2
74
0
3
Order By: Relevance
“…Previous reports have revealed that the transcriptional activity of PPAR␥2 is modulated by phosphorylation, sumoylation, ubiquitylation, and nitration (41). Phosphorylation of PPAR␥2 is presumed to be the most significant negative posttranscriptional regulator among them (42).…”
Section: Discussionmentioning
confidence: 99%
“…Previous reports have revealed that the transcriptional activity of PPAR␥2 is modulated by phosphorylation, sumoylation, ubiquitylation, and nitration (41). Phosphorylation of PPAR␥2 is presumed to be the most significant negative posttranscriptional regulator among them (42).…”
Section: Discussionmentioning
confidence: 99%
“…In our work, a compensatory increase in PPARγ gene expression was observed in adipocytes in comparison with pre-adipocytes and treated adipocytes. Furthermore, the activity of PPARγ can be nely tuned through integration of diverse phosphorylation events [33,34]. In this regard, a downward trend in PPARγ protein levels in cells treated with telmisartan for 6 hours in comparison with the untreated group.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, DNA binding was assessed as a measure of PPARg activation in all the reports studying the functions of PPARs in platelets without exception (Akbiyik et al, 2004;Ali et al, 2006Ali et al, , 2009aKhanolkar et al, 2008;Ray et al, 2008;Moraes et al, 2010). Fortunately, nongenomic, nontranscriptional activities of PPARg are being uncovered (Bishop-Bailey, 2010;Luconi et al, 2010), and such progress may allow us to elucidate the working mechanism of platelet PPARg.…”
Section: Antiplatelet Effects Of Thiazolidinedionesmentioning
confidence: 99%