Peroxo Complexes of Th(IV) and Zr(IV) Ions Containing Aspartic Acid and Amine Bases as Potential Biological Agents

Bitu, Nur Amin; Hossain, Saddam; Islam, Nashreen S.; Kader, Abdul; Islam, Md. Saiful; Haque, M. M.; Hossen, Faruk; Asraf, Ali; Mohapatra, R. K.; Kudrat-E-Zahan,

doi:10.1134/s1070363220080253

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…The inhibitory effect of L-Asp has been well-studied and applied for fungal inhibition in food products. Bitu et al [47] used L-Asp combined with Th (IV) and Zr (IV) ions to synthesize new peroxo complexes, and demonstrated high antibacterial activity in Aspergillusflavus, Penicillium sp., Candida sp. and Aspergillus niger.…”

Section: Dose-effect Relationship Between L-thr L-his and L-asp On T-...mentioning

confidence: 99%

Effect of Amino Acids on Fusarium oxysporum Growth and Pathogenicity Regulated by TORC1-Tap42 Gene and Related Interaction Protein Analysis

Deng

Zhang

Lǐ

et al. 2023

Foods

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Free amino acids (AAs) formed in fermented meat products are important nitrogen sources for the survival and metabolism of contaminating fungi. These AAs are mainly regulated by the TORC1-Tap42 signaling pathway. Fusarium spp., a common contaminant of fermented products, is a potential threat to food safety. Therefore, there is an urgent need to clarify the effect of different AAs on Fusarium spp. growth and metabolism. This study investigated the effect of 18 AAs on Fusarium oxysporum (Fo17) growth, sporulation, T-2 toxin (T-2) synthesis and Tri5 expression through Tap42 gene regulation. Co-immunoprecipitation and Q Exactive LC-MS/MS methods were used to detect the interacting protein of Tap42 during specific AA treatment. Tap42 positively regulated L-His, L-Ile and L-Tyr absorption for Fo17 colony growth. Acidic (L-Asp, L-Glu) and sulfur-containing (L-Cys, L-Met) AAs significantly inhibited the Fo17 growth which was not regulated by Tap42. The L-Ile and L-Pro addition significantly activated the sporulation of ΔFoTap42. L-His and L-Ser inhibited the sporulation of ΔFoTap42. In T-2 synthesis, ΔFoTap42 was increased in GYM medium, but was markedly inhibited in L-Asp and L-Glu addition groups. Dose–response experiments showed that 10–70 mg/mL of neutral AA (L-Thr) and alkaline AA (L-His) significantly increased the T-2 production and Tri5 expression of Fo17, but Tri5 expression was not activated in ΔFoTap42. Inhibition of T-2 synthesis and Tri5 expression were observed in Fo17 following the addition of 30–70 mg/mL L-Asp. KEGG enrichment pathway analysis demonstrated that interacting proteins of Tap42 were from glycerophospholipid metabolism, pentose phosphate pathway, glyoxylate and dicarboxylate metabolism, glycolysis and gluconeogenesis, and were related to the MAPK and Hippo signaling pathways. This study enhanced our understanding of AA regulation in fermented foods and its effect on Fusarium growth and metabolism, and provided insight into potential ways to control fungal contamination in high-protein fermented foods.

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Section: Dose-effect Relationship Between L-thr L-his and L-asp On T-...mentioning

confidence: 99%

Effect of Amino Acids on Fusarium oxysporum Growth and Pathogenicity Regulated by TORC1-Tap42 Gene and Related Interaction Protein Analysis

Deng

Zhang

Lǐ

et al. 2023

Foods

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“…Antibacterial activities of the synthesized complexes are investigated by using the traditional disc diffusion method (Elachi et al, 2019;and Bitu et al, 2020). The complexes (50 mg/disc in DMSO solution) were screened for their antibacterial activity against two Gram positive bacteria Escherichia coli and Pseudomonas aeruginosa and two Gram negative bacteria Staphylococcus aureus and Bacillus cereus with Kanamycin (K-30) standard (Haque et al, 2005;Ali et al, 2020a;2020b;and 2020c).…”

Section: Antibacterial Activity Of the Complexesmentioning

confidence: 99%

Mixed Ligand Oxovanadium (IV) Complexes of 5,6-Dimethyl-1,10-phenanthroline and Amino Acid Schiff Bases Containing Salicylaldehyde: Synthesis and Characterization with Antibacterial Properties

Bitu¹,

Hossain²,

Asraf³

et al. 2021

African Journal of Pharmaceutical Sciences

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Five new oxovanadium (IV) complexes have been synthesized from two mixed ligand, 5,6-Dimethyl-1,10-phenanthroline and amino acid derived Schiff bases containing salicylaldehyde. All the synthesized complexes were characterized by some physicochemical properties, molar conductance, magnetic susceptibilities measurements, elemental analysis, UV-Visible and IR spectral studies. The molar conductance values reveal the non-electrolytic nature of the complexes. The magnetic moment values indicate that the complexes are paramagnetic in nature. IR spectral data indicates the coordination of tridentate amino acid Schiff base ligands to the vanadyl (VO 2+ ) ion through O, N, Odonor. ESI-MS spectral data confirms the proposed molecular formula of the complexes. All the analytical data suggested that all the complexes possess to have distorted octahedral geometry. Antibacterial activity of the complexes was tested against two Gram positive bacteria Escherichia coli and Pseudomonas aeruginosa and two Gram negative bacteria Staphylococcus aureus and Bacillus cereus with Kanamycin (K-30) standard. The result shows that all the complexes possess to have moderate to strong potential antibacterial activity against all the tested pathogenic bacteria.

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“…Antibacterial activities of the complexes are investigated by using the highly adoptable disc diffusion method. [23,24] The complexes (50 µg / disc in DMSO solution) were screened for their antibacterial activity against four human pathogenic bacteria; two Gram positive Escherichia coli & Pseudomonas aeruginosa and two Gram negative Staphylococcus aureus & Bacillus cereus with Kanamycin (K-30) standard. [25][26][27][28] Overtone's concept and Tweedy's chelation theory can explain the greater activity of the complexes.…”

Section: Antibacterial Activity Of the Complexesmentioning

confidence: 99%

Synthesis, Characterization and Biological Activity of Oxovanadium(IV) Complexes Containing α-Amino Acid Schiff Bases and 5,6-Dimethyl-1,10-phenanthroline Ligands

et al. 2020

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Five oxovanadium(IV) complexes of the type [VO(L)(DPhen)], containing Schiff base derived from α-amino acid, [where L = 3-hydroxybenzaldehyde-α-alanine (hb-Ala), 3-hydroxybenzaldehyde-DL-phenylalanine (hb-Phe), 3-hydroxybenzaldehyde-leucine (hb-Leu), 3-hydroxybenzaldehyde-glycine (hb-Gly) and 3-hydroxybenzaldehyde-DL-methionine (hb-Met) & DPhen = 5,6-Dimethyl-1,10-phenanthroline] have been synthesized and characterized by some physicochemical properties, molar conductance, magnetic susceptibilities measurements, elemental analysis, UV-Visible, FT-IR and EIS-MS spectral studies. The molar conductance values evidenced the non-electrolytic nature of the complexes. The magnetic moment values of the complexes are in accordance with the d 1 electronic configuration of the V IV O 2+ moiety and indicates the paramagnetic behavior of the complexes. IR spectral data indicates the coordination of tridentate amino acid Schiff base ligands to the vanadyl (VO 2+ ) ion through O, N, O-donor. ESI-MS spectral study confirmed the proposed structure of the complexes. All the analytical data suggested that all the complexes possess to have distorted octahedral geometry. The complexes were screened for their antibacterial activity against four human pathogenic bacteria; two Gram positive Escherichia coli & Pseudomonas aeruginosa and two Gram negative Staphylococcus aureus & Bacillus cereus with Kanamycin (K-30) standard. The result shows that all the complexes have moderate to strong potential antibacterial activity against all the pathogenic bacteria.

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Peroxo Complexes of Th(IV) and Zr(IV) Ions Containing Aspartic Acid and Amine Bases as Potential Biological Agents

Cited by 5 publications

References 15 publications

Effect of Amino Acids on Fusarium oxysporum Growth and Pathogenicity Regulated by TORC1-Tap42 Gene and Related Interaction Protein Analysis

Effect of Amino Acids on Fusarium oxysporum Growth and Pathogenicity Regulated by TORC1-Tap42 Gene and Related Interaction Protein Analysis

Mixed Ligand Oxovanadium (IV) Complexes of 5,6-Dimethyl-1,10-phenanthroline and Amino Acid Schiff Bases Containing Salicylaldehyde: Synthesis and Characterization with Antibacterial Properties

Synthesis, Characterization and Biological Activity of Oxovanadium(IV) Complexes Containing α-Amino Acid Schiff Bases and 5,6-Dimethyl-1,10-phenanthroline Ligands

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