By a semi-empirical Green's function method we calculate conductances and the corresponding Giant Magneto-Resistance effects (GMR) of two metallic ferromagnetic films separated by different spacers, metallic and non-metallic ones, in a simplified model on a sc lattice, in CPP and CIP geometries (i.e. current perpendicular or parallel to the planes), without impurities, or with interface-or bulk impurities. The electronic structure of the systems is approximated by two hybridized orbitals per atom, to mimic s-bands and d-bands and their hybridization.We show that such calculations usually give rough estimates only, but of the correct order of magnitude; in particular, the predictions on the impurity effects depend strongly on the model parameters. One of our main results is the prediction of huge CPP-GMR effects for non-metallic spacers in the ballistic limit.