Persistan Eritema Multiforme

Abstract

ÖzetEritema multiforme (EM) özellikle akral bölgelere yerleşim gösteren, tipik olarak hedef benzeri eritemli makül ve papüllerle karakterize mukokutanöz bir deri hastalığıdır. Klinik olarak klasik, rekürren ve persistan tip olarak 3 alt grupta sınıflandırılmaktadır. Persistan eritema multiforme (PEM), sürekli görülen tipik EM lezyonları ve eritematöz papül-plaklar, hedef tarzı lezyonlar, büller ve nekrotik lezyonlar gibi atipik deri ve mukoza lezyonları ile karakterize EM'nin nadir bir varyantıdır. Burada persistan eritema multiforme tanısı konulan ve asiklovir tedavisi ile düzelen 30 yaşında bir kadın hasta sunuyoruz. Ek olarak, olgumuz Türkiye'de rapor edilen PEM'li ilk olgudur. (Türk derm 2011; 45: 210-12) Anah tar Ke li me ler: Eritema multiforme, persistan, asiklovir Sum maryErythema multiforme (EM) is a mucocutaneous disease characterized by the typical target-like erythematous papules and plaques especially localized on the acral regions. It is classified clinically into three subgroups as classical, recurrent and persistent type. Persistent EM (PEM) is a rare variant of EM characterized by the continuous appearance of typical EM lesions and atypical cutaneous or mucosal lesions such as erythematous papules-plaques, targetoid lesions, blistering and necrotic lesions. PEM can be induced by viruses or some malignant and inflammatory underlying diseases although there are some idiopathic cases. Here, we report a 30-year-old woman who was diagnosed as PEM and responded well to treatment with acyclovir. In addition, our case is the first reported case with PEM in Turkey. (Turk derm 2011; 45: 210-12

Herpes Virüs İlişkili Tekrarlayan Eritema Multiforme Olgularımızda Valasiklovir Profilaksisi Kullanımı

“…Detection of interferon-gama (IFN-γ) in HAEM lesions can also be used as evidence of viral antigens (6). Detecting specific IgM and IgG antibodies to identify HSV-1 and HSV-2 may confirm a suspected history of HSV infection, although it is not necessary for diagnosis (8). We did not consider biopsy because our patients had clinical signs of herpes labialis before typical rashes and had serologically detected HSV-1 positivity.…”