Persistence and Recovery of ZIF-8 and ZIF-67 Phytotoxicity

Zhang, Xiaolin; Hu, Xiangang; Wu, Hao

doi:10.1021/acs.est.1c05838

Cited by 62 publications

(19 citation statements)

References 74 publications

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“…Our results show that RBITC@ZIF-8 MOF nanoparticles showed no significant toxicity under in vivo conditions in C. elegans. The existing results were comparable with the work reported by Zhang et al (2021) on algae. In this work, the authors reported that the exposure of ZIF-8 MOFs at concentrations as low as 0.01-1 μg ml −1 can induce a significant level of inhibition of algal growth, chloroplast damage, membrane permeability, alteration in the biosynthesis of chlorophyll etc.…”

Section: In Vivo Studiessupporting

confidence: 90%

“…However, the authors reported that these effects could be reversible. The adversity caused by ZIF-8 was reportedly weak as a majority of the effects were restored by the worms after some time (Zhang et al, 2021). In our case, the brood size and the life span of the worms didn't show any change (postexposure to RBITC@ZIF-8 MOF nanoparticles) as compared to the control.…”

Section: In Vivo Studiescontrasting

confidence: 52%

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Toxicological Impact and in Vivo Tracing of Rhodamine Functionalised ZIF-8 Nanoparticles

et al. 2022

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Metal Organic Frameworks (MOFs) are extensively used for a wide range of applications due to their exceptionally high surface area. MOF particles are conventionally in micron size, but the nanosized MOFs show good transportation/mobility due to their small size, and when combined with the high surface area of MOFs, it makes MOF nanoparticles an ideal candidate to study for environmental remediation. Therefore, it is important to study the ecotoxicological impact of these MOFs. In this study, we developed rhodamine labelled nanoparticles of zinc imidazolate metal organic framework (ZIF-8 MOFs) as a means of in vivo tracing the MOF translocation in C. elegans. Rhodamine B isothiocyanate functionalized ZIF-8 MOFs nanoparticles (RBITC@ZIF-8 MOF nanoparticles; size 44 ± 7 nm) were fed to the worms naturally within a concentration range of 0.16–16.4 μg mg−1. Fluorescence was detected in the pharyngeal and gut lumen regions of the worms after 4 h of treatment, for exposure concentrations >0.163 μg mg−1. A higher intensity of fluorescence was observed at the end of 24 h for all exposure concentrations. Worms treated with RBITC@ZIF-8 MOF concentrations of ≥1.63 μg mg−1 for 24 h showed a bright stable fluorescence signal at the tail region. The uptake of RBITC@ZIF-8 MOF for an exposure concentration of 0.163, 1.63, and 8.2 μg mg−1 was found to be 52.1, 11.4 and 28.6%, respectively. Through this study, we showed that RBITC@ZIF-8 MOFs can be exposed to C. elegans and imaged at low concentrations of ∼0.16 μg mg−1.

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Section: In Vivo Studiessupporting

confidence: 90%

Section: In Vivo Studiescontrasting

confidence: 52%

Toxicological Impact and in Vivo Tracing of Rhodamine Functionalised ZIF-8 Nanoparticles

et al. 2022

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“…In contrast, combined exposure to CPC and 60-mg/L ZIF-NPs did not significantly increase the MDA level in zebrafish larvae; even this mixture significantly elevated their ROS level and decreased their T-SOD activity. A possible explanation is the dose-specific effects of ZIF-NPs on organisms, which have been well documented by recent studies [11,44,45]. Another possible explanation is that the interactions between components in mixtures exhibit complex effects on their joint toxicity, which is affected by many factors, such as the combination of a mixture, their dose level, dose ratio, and others [46,47].…”

Section: Discussionmentioning

confidence: 86%

Zeolitic Imidazolate Framework-8 Nanoparticles Exhibit More Severe Toxicity to the Embryo/Larvae of Zebrafish (Danio rerio) When Co-Exposed with Cetylpyridinium Chloride

Qiu

Liu

et al. 2022

Antioxidants

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The combined application of nanoparticles and surfactants has attracted tremendous attention in basic research and industry. However, knowledge of their combined toxicity remains scarce. In this study, we exposed zebrafish embryos to cetylpyridinium chloride (CPC, a cationic surfactant, at 0 and 20 μg/L), zeolitic imidazolate framework nanoparticles (ZIF-NPs, at 0, 30, and 60 mg/L), and their mixtures until 120 h post-fertilization (hpf). Within the used concentration range, both single and combined exposures exhibited limited effects on the survival and hatching of zebrafish. However, the combined exposure of ZIF-NPs and CPC caused more severe effects on the heart rate at both 48 and 72 hpf. The combined exposure also induced significant hyperactivity (i.e., increasing the average swimming velocity) and oxidative stress in zebrafish larvae (at 120 hpf), although all single exposure treatments exhibited limited impacts. Furthermore, the level of reactive oxygen species (or malondialdehyde) exhibited a significantly positive correlation with the heart rate (or average swimming velocity) of zebrafish, suggesting that oxidative stress plays a role in mediating the combined toxicity of CPC and ZIF-NPs to zebrafish. Our findings suggest that the interaction of CPC and ZIF-NPs should not be ignored when assessing the potential risks of their mixtures.

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“…The toxic effects of Zn(II)‐based ZIF‐8 and Co(II)‐based ZIF‐67 on plant cells were studied by Hu's group. [ 69 ] ZIF‐67 at low concentrations (0.01–1 mg mL −1 ) significantly inhibited the growth of algal and chlorophyll biosynthesis accompanied with the reduction of ROS while ZIF‐8 was nontoxic. The transcriptional omics studies revealed that the downregulation of oxidative phosphorylation and the adenosine triphosphate (ATP) synthesis inhibition of chlorophyll in mitochondria were responses to these toxic effects ( Figure ).…”

Section: Key Factors Affecting the Cytotoxicity Of Mofsmentioning

confidence: 99%

“…a) Density of algae; b) chlorophyll a content of the algae; c) F v / F m value of the algae exposed to ZIF‐8 or ZIF‐67; d) cell permeability; e) mitochondrial membrane potential; and f) ROS level. Reproduced with permission [69a] . Copyright 2021, American Chemical Society.…”

Section: Key Factors Affecting the Cytotoxicity Of Mofsmentioning

confidence: 99%

Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

Fang

Yan

2022

Small Science

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Reticular chemistry has become a powerful tool for scientists to design crystalline porous materials with different fundamental units. [1] Over the past decades, porous materials have gained great attention due to their outstanding performance and wide applications. Among various porous materials, the combination of metal nodes and organic linkers by coordination bonds creates new hybrid porous materials called metal-organic frameworks (MOFs) and opens a new window in the design of porous materials.Since the first report on MOFs by Yaghi's group in 1995, [2] more than 100 000 kinds of MOFs have been synthesized according to the Cambridge Structural Database (CSD). The unique characteristics, including tunable porosity, customized chemical composition, large specific surface area, and easy functionalization, make MOFs promising candidates for numerous applications in diverse fields such as gas storage and separation, catalysis, sensing, adsorption, energy, and biomedical sciences. [3] In addition, the large-scale production and commercialization of MOFs began from 2016. [4] For instance, the commercial MOF adsorbent for storage of 1-methylcyclopropene to ripen vegetables and fruits was driven to the market. [5] The Numat's ION-X gas cylinder was designed based on the MOF adsorbent to store hazardous gases for semiconductor industry, showing significant advantages over traditional adsorbents. [3a] Apart from the commercialization in gas storage, the MOF-303-based apparatus has been used to collect water in the desert. [6] Despite the advantages of MOFs, the wide application of MOFs has led to environmental health risks. The accidental release of MOF particles into the environment from their bulk-products is inevitable during the lifecycle of MOFs. The deposition, decomposition, and distribution of released MOFs in environmental media could result in the exposure to humans and other organisms, inducing various biological effects. In addition, the intentional administration of MOFs in biomedicine (such as bioimaging, drug delivery system) also leads to the exposure risks to humans. Under these circumstances, the environmental health risks of MOFs are unavoidable.The toxicity of MOFs plays an important role in their health risk assessment. Compared with in vivo and ex vivo toxicity assessments, in vitro toxicity evaluation based on cell culture is low cost, fast, and high throughput, making it an ideal model in toxicity research. As the basic unit in organism, cells play an important role in life activity. The toxic effects on cells would affect their function and therefore induce significant response

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Persistence and Recovery of ZIF-8 and ZIF-67 Phytotoxicity

Cited by 62 publications

References 74 publications

Toxicological Impact and in Vivo Tracing of Rhodamine Functionalised ZIF-8 Nanoparticles

Toxicological Impact and in Vivo Tracing of Rhodamine Functionalised ZIF-8 Nanoparticles

Zeolitic Imidazolate Framework-8 Nanoparticles Exhibit More Severe Toxicity to the Embryo/Larvae of Zebrafish (Danio rerio) When Co-Exposed with Cetylpyridinium Chloride

Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

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