Persistence of Candida species in the respiratory tract of cystic fibrosis patients

Muthig, Michaela; Hebestreit, Alexandra; Ziegler, Uwe; Seidler, Marc; Muller, F.L.

doi:10.1080/13693780802716532

Cited by 16 publications

(23 citation statements)

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“…Recent studies have clearly indicated an increase in the prevalence rate of yeast and filamentous fungi colonising the CF airway 4 . In our study, C. albicans was detected with the highest prevalence (62.5%), which is in accordance with the data noted in the literature (29.4–93%) 16,17 . Significant long‐term persistence and strain maintenance of Candida species have been shown in CF respiratory tracts 16 .…”

Section: Discussionsupporting

confidence: 91%

Frequency of fungi in respiratory samples from Turkish cystic fibrosis patients

Güngör¹,

Tamay²,

Güler³

et al. 2012

Mycoses

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An increased isolation of fungi from the respiratory tract of patients with cystic fibrosis (CF) has been reported. The prevalence of different fungi in CF patients from Turkey is not known. Our aim was to determine the frequency of fungi in the respiratory tract of Turkish CF patients. We investigated a total of 184 samples from 48 patients. Samples were inoculated on Medium B+ and CHROMagar Candida. Candida albicans was the predominant yeast isolated [30 patients (62.5%)], followed by C. parapsilosis [6 (12.5%)] and C. dubliniensis 5 (10.4%). Aspergillus fumigatus was the most common filamentous fungus [5 (10.4%)] and non-fumigatus Aspergillus species were isolated from four (8.3%) patients. Staphylococcus aureus was the most frequently detected bacterium in C. albicans positive samples (53.57%). A. fumigatus and Pseudomonas aeruginosa or S. aureus were detected together in 75% of A. fumigatus positive samples each. No statistically significant relationship was detected between growth of yeast and moulds and age, gender, the use of inhaled corticosteroids or tobramycin. No significant correlation was found between the isolation of C. albicans, A. fumigatus and P. aeruginosa, Stenotrophomonas maltophilia or S. aureus, and the isolation of C. albicans and Haemophilus influenzae. Other factors which may be responsible for the increased isolation of fungi in CF need to be investigated.

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Section: Discussionsupporting

confidence: 91%

Frequency of fungi in respiratory samples from Turkish cystic fibrosis patients

Güngör¹,

Tamay²,

Güler³

et al. 2012

Mycoses

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“…Some of the most common isolates from human bronchiolar lavage samples of CF patients are Pseudomonas aeruginosa, S. aureus, Streptococcus milleri group (SMG) pathogens, Burkholderia cepacia, Stenotrophomonas maltophilia, H. influenzae, and C. albicans. However, this list ignores members of the normal flora that are not regularly screened in the clinical laboratory (143,179,182,194). Several interesting findings and trends from coinfections with several of these pathogens will be discussed.…”

Section: Infection Of the Cystic Fibrosis Lungmentioning

confidence: 99%

Polymicrobial Interactions: Impact on Pathogenesis and Human Disease

et al. 2012

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SUMMARY Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or within the human body, often as multifaceted polymicrobial biofilm communities at mucosal sites and on abiotic surfaces. Only recently have we begun to appreciate the complicated biofilm phenotype during infection; moreover, even less is known about the interactions that occur between microorganisms during polymicrobial growth and their implications in human disease. Therefore, this review focuses on polymicrobial biofilm-mediated infections and examines the contribution of bacterial-bacterial, bacterial-fungal, and bacterial-viral interactions during human infection and potential strategies for protection against such diseases.

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“…Among the organisms identified, filamentous fungi belonging to the genera Aspergillus and Penicillium had previously been suggested as pathogens in CF patients [139]. Candida albicans and C. parapsilosis were also recently described as colonizer organisms of CF patients [140,141]. A significant proportion of other identified species were fungi also detected in patients with asthma (Didymella exitialis, Penicillium camemberti), allergic responses (A. penicilloides and Eurotium halophilicum) [142,143], or infectious diseases (Kluyveromyces lactis, Malassezia sp., Cryptococci non-neoformans, Chalara sp.)…”

mentioning

confidence: 99%

Richness and diversity of mammalian fungal communities shape innate and adaptive immunity in health and disease

2014

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Human holobiomes are networks of mutualistic interactions between human cells and complex communities of bacteria and fungi that colonize the human body. The immune system must tolerate colonization with commensal bacteria and fungi but defend against invasion by either organism. Molecular ecological surveys of the human prokaryotic microbiota performed to date have revealed a remarkable degree of bacterial diversity and functionality. However, there is a dearth of information regarding the eukaryotic composition of the microbiota. In this review, we describe the ecology and the human niches of our fungal "fellow travelers" in both health and disease, discriminating between passengers, colonizers, and pathogens based on the interaction of these fungi with the human immune system. We conclude by highlighting the need to reconsider the etiology of many fungal and immune-related diseases in the context of the crosstalk between the human system and its resident microbial communities.Keywords: Dysbiosis r Fungal metagenomics r Host-microbe interaction r Mycobiota IntroductionHumans live in close association with a complex community of bacteria, viruses, fungi, and archaea [1][2][3], which inhabit their bodies. Many groups have surveyed these microbial populations using the so-called "next generation" or "deep" sequencing approaches, revealing that the human microbiota differs radically at various body sites and among individuals [2][3][4]. The differences in the human microbiota are influenced by the availability of nutrients, environmental exposure to microorganisms, and other sitespecific features, such as the immunological makeup of a given location. The origin of differences in the microbiota between individuals potentially reflects different patterns of colonization early in life (reviewed in [5]), different dietary regimens [6,7], and different environmental exposures, such as antibiotic use [8,9]. Recently, the application of deep sequencing approaches have genCorrespondence: Dr. Duccio Cavalieri e-mail: duccio.cavalieri@fmach.it erated novel hypotheses about the microbial determinants underlying human disorders of immune origin (reviewed in [10]). Several metabolites of the interaction between diet and host microbiota, such as short-chain fatty acids, have been shown to play a fundamental role in shaping immune responses (reviewed in [11]). The application of microbial ecology concepts is ultimately leading to the conclusion that health and disease can be understood only through an understanding of the ways in which the symbiotic interactions between microbes and human organs harmonically integrate in the context of the hologenome [12].Human microbial diversity is not limited to bacteria; microorganisms such as fungi also play major roles in the stability of microbial communities in human health and disease (reviewed in [13]). Yeasts were detected in human stool samples as far back as 1917, and by the mid-20th century the presence of yeasts in the human intestine was proposed to have a saprotrophic role [14]....

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Persistence of Candida species in the respiratory tract of cystic fibrosis patients

Cited by 16 publications

References 0 publications

Frequency of fungi in respiratory samples from Turkish cystic fibrosis patients

Frequency of fungi in respiratory samples from Turkish cystic fibrosis patients

Polymicrobial Interactions: Impact on Pathogenesis and Human Disease

Richness and diversity of mammalian fungal communities shape innate and adaptive immunity in health and disease

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