Persistence of chromosome aberrations in peripheral lymphocytes from Hodgkin's lymphoma remission patients

Ryabchenko, Nikolay I.; Nasonova, Valentina A.; Antoschina, Margarita M.; Fesenko, E.V.; Kondrashova, Tatiana V.; Иванова, Т. И.; Павлов, В. В.; Ryabikhina, N; Terekhova, A. Yu.

doi:10.1080/0955300031000102650

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…A similar observation was reported by Ryabchenko et al [14]. They analyzed spontaneous chromosome aberrations in peripheral lymphocytes taken from Hodgkin's disease patients after prolonged (up to 31 years) remission periods.…”

Section: Radiotherapy Patientssupporting

confidence: 65%

Towards resolving conflicting reports of radiation-induced genomic instability in populations exposed to ionizing radiation: Implications for the hibakusha

Morgan

Sowa

2007

International Congress Series

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Section: Radiotherapy Patientssupporting

confidence: 65%

Towards resolving conflicting reports of radiation-induced genomic instability in populations exposed to ionizing radiation: Implications for the hibakusha

Morgan

Sowa

2007

International Congress Series

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“…Previous studies that analyzed chromosomal abnormalities using nonbanded chromosomes or FISH, have found a significantly increased frequency of structural chromosomal aberrations in HL patients treated with MOPP chemotherapy in combination with radiotherapy [Papa et al, 1984;Smith et al, 1992;Bilban-Jakopin and Bilban, 2001;M'Kacher et al, 2003;Ryabchenko et al, 2003]. Smith et al [1992] analyzed five HL patients 12-21 years after treatment with chemotherapy/radiotherapy, using chromosome 4 painting probe and found a high frequency of chromosomal translocations (mean 5 0.016).…”

Section: Complex Structural Chromosome Damage Is Increased In Hl Survmentioning

confidence: 99%

Persistent genomic instability in peripheral blood lymphocytes from hodgkin lymphoma survivors

Salas-Labadía¹,

Niembro²,

Lozano³

et al. 2012

Environ and Mol Mutagen

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Advances in cancer treatment have led to an increase in patient survival. However, exposure to genotoxic chemotherapeutic agents and ionizing radiation may induce persistent genetic damage in cancer survivors. In this study, we detected genomic instability in chromosomes of peripheral blood lymphocytes from Hodgkin lymphoma patients, 2–17 years after MOPP (nitrogen mustard, Oncovin, procarbazine, and prednisone) chemotherapy with or without radiotherapy. Samples were obtained from 11 healthy individuals, 5 pretreatment patients, and 20 posttreatment patients. Cytogenetic analysis with GTG banding was performed on 1,000 lymphocyte metaphases per donor to identify genomic instability, including numerical and structural chromosomal aberrations, at a resolution of 10 Mb across the entire genome. Our results showed that anticancer treatment did not induce significant differences in the frequency of aneuploidy among the three study groups. However, 1 of the 11 healthy individuals, and 13 of the 20 posttreatment patients had a high frequency of chromosomal breaks and gross chromosomal rearrangements. The types of aberrations observed were random and complex, consistent with persistent genomic instability that was induced by cancer treatment. Clonal expansion of cells with chromosomal lesions was observed in one posttreatment patient only. These findings show that anticancer treatments induce persistent genomic instability, but not aneuploidy. Chemotherapy may affect genes with a role in DNA damage surveillance or repair, which in turn allows the accumulation of nontargeted structural chromosomal damage in future generations of cells. This genomic instability may facilitate the development of second malignancies in Hodgkin lymphoma survivors. Environ. Mol. Mutagen. 2012. © 2012 Wiley Periodicals, Inc.

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“…There are several studies showing that CT/RT have a genotoxic effect on somatic cells from HL patients [8,11,27,33,36,51,52,53]. Smith and colleagues [27] detected the genotoxic effects induced by MOPP/RT treatment through painting of chromosome 4 in lymphocytes from patients who were treated 12 to 24 years before the study.…”

Section: Impact Of Anticancer Therapy In Noncancerous Somatic Cellmentioning

confidence: 99%

Nonclonal Chromosome Aberrations and Genome Chaos in Somatic and Germ Cells from Patients and Survivors of Hodgkin Lymphoma

Frias

Ramos

Salas-Labadía

et al. 2019

Genes

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Anticancer regimens for Hodgkin lymphoma (HL) patients include highly genotoxic drugs that have been very successful in killing tumor cells and providing a 90% disease-free survival at five years. However, some of these treatments do not have a specific cell target, damaging both cancerous and normal cells. Thus, HL survivors have a high risk of developing new primary cancers, both hematologic and solid tumors, which have been related to treatment. Several studies have shown that after treatment, HL patients and survivors present persistent chromosomal instability, including nonclonal chromosomal aberrations. The frequency and type of chromosomal abnormalities appear to depend on the type of therapy and the cell type examined. For example, MOPP chemotherapy affects hematopoietic and germ stem cells leading to long-term genotoxic effects and azoospermia, while ABVD chemotherapy affects transiently sperm cells, with most of the patients showing recovery of spermatogenesis. Both regimens have long-term effects in somatic cells, presenting nonclonal chromosomal aberrations and genomic chaos in a fraction of noncancerous cells. This is a source of karyotypic heterogeneity that could eventually generate a more stable population acquiring clonal chromosomal aberrations and leading towards the development of a new cancer.

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Persistence of chromosome aberrations in peripheral lymphocytes from Hodgkin's lymphoma remission patients

Cited by 5 publications

References 14 publications

Towards resolving conflicting reports of radiation-induced genomic instability in populations exposed to ionizing radiation: Implications for the hibakusha

Towards resolving conflicting reports of radiation-induced genomic instability in populations exposed to ionizing radiation: Implications for the hibakusha

Persistent genomic instability in peripheral blood lymphocytes from hodgkin lymphoma survivors

Nonclonal Chromosome Aberrations and Genome Chaos in Somatic and Germ Cells from Patients and Survivors of Hodgkin Lymphoma

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