Persistence of one-trial cocaine-induced behavioral sensitization in young rats: regional differences in Fos immunoreactivity

McDougall, Sanders A.; Charntikov, Sergios; Cortez, Anthony M.; Amodeo, Dionisio A.; Martínez, Cynthia Espinosa; Crawford, Cynthia A.

doi:10.1007/s00213-008-1407-1

Cited by 15 publications

(20 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lastly, the persistence of one-trial behavioral sensitization differs dramatically according to age. During adulthood, a sensitized response can be detected for months after a single pretreatment injection of cocaine or amphetamine (Robinson et al 1982; Valjent et al 2010), whereas preweanling rats only exhibit one-trial behavioral sensitization for a few days after initial drug exposure (McDougall et al 2009a). Together, these results suggest that the behavioral manifestations and underlying mechanisms mediating one-trial behavioral sensitization differ across ontogeny.…”

Section: Discussionmentioning

confidence: 99%

“…For example, psychostimulant-induced behavioral sensitization appears to be weaker and less persistent in preweanling rats than adults (Smith and Morrell 2008; McDougall et al 2009a). Similar to adults, the multi-trial behavioral sensitization of preweanling rats is influenced by associative processes, because sensitized responding is more persistent if drug pretreatment and testing occur in the same environmental context (Wood et al 1998; Zavala et al 2000).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

et al. 2014

Self Cite

View full text Add to dashboard Cite

Rationale The neural mechanisms mediating the ontogeny of behavioral sensitization are poorly understood. Objective The purpose of the present study was to determine the role of the D1 receptor for the induction of dopamine agonist-induced behavioral sensitization during the preweanling period. Methods In the first experiment, the early ontogeny of NPA-induced behavioral sensitization was examined by pretreating male and female rats with saline or NPA (0.5, 1, or 2 mg/kg, IP) before placement in activity chambers on postnatal day (PD) 12, 16, 20, or 24. One day later, rats were tested with lower doses of NPA and the occurrence of locomotor sensitization was determined. In subsequent experiments, rats were injected with saline or the D1 receptor antagonist SCH23390 (0.1, 0.5, 1, or 5 mg/kg, IP) 0, 15, 30, or 60 min before cocaine, methamphetamine (METH), or NPA pretreatment. The next day, rats were tested with the same dopamine agonist again and sensitized responding was assessed. Results NPA produced one-trial behavioral sensitization at all ages tested. In preweanling rats, SCH23390, regardless of dose, was ineffective at preventing the induction of cocaine-, METH-, or NPA-induced one-trial behavioral sensitization. Conclusions The present results are in partial contrast to adult rodent studies, in which SCH23390 blocks the induction of METH- and apomorphine-induced behavioral sensitization, but not cocaine sensitization. When these findings are considered together, it appears that D1 receptor stimulation is not necessary for the induction of behavioral sensitization during the preweanling period, although D1 receptors may play a more important role in adulthood.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, drug affinity and/or pharmacokinetic factors (e.g., a short half-life) may endow cocaine with a unique ability to induce one-trial behavioral sensitization in preweanling rats. Whichever explanation is correct, it would have to be specific to young animals because adult rats and mice exhibit one-trial sensitization to both amphetamine and cocaine (Drew and Glick, 1989; Weiss et al ., 1989; Battisti et al ., 2000; McDougall et al , 2009a). …”

Section: Introductionmentioning

confidence: 99%

Ontogeny of methamphetamine-induced and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats

Kozanian¹,

Gutierrez²,

Mohd-Yusof³

et al. 2012

Behavioural Pharmacology

Self Cite

View full text Add to dashboard Cite

The ontogenetic profile of psychostimulant-induced one-trial behavioral sensitization has not been determined. The purpose of this study was to systematically assess the ontogeny of methamphetamine- and cocaine-induced behavioral sensitization across the preweanling and adolescent periods. To this end, rats were injected with methamphetamine, cocaine, or saline in either an activity chamber or home cage during the preweanling (PD 12, PD 16, or PD 20), preadolescent (PD 24), or adolescent (PD 34) periods. One day later, rats were challenged with the same psychostimulant and locomotion was measured in an activity chamber. Results showed that methamphetamine produced one-trial locomotor sensitization on PD 13 and PD 17; whereas, cocaine-induced behavioral sensitization was only evident on PD 21. The sensitized responding of preweanling rats was not influenced by environmental context. Interestingly, preadolescent and adolescent rats did not exhibit locomotor sensitization. The latter result is generally consistent with past studies showing that rats from the middle and late adolescent periods do not exhibit cocaine-induced one-trial behavioral sensitization. The present results show that methamphetamine, as well as cocaine, can produce one-trial context-independent behavioral sensitization during early ontogeny, but sensitized responding is only apparent within a narrow developmental window.

show abstract

“…As a consequence, sensitized responding is less likely to be confounded with maturational changes in motoric ability or programmed alterations in CNS functioning. Unlike with adult rats, the sensitized response of preweanling rats shows little persistence (McDougall et al 2009a), so the one-trial procedure is not appropriate when long-term sensitization is of interest.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike adults, however, the one-trial behavioral sensitization of preweanling rats is context-independent (McDougall et al 2009b; Herbert et al 2010; Kozanian et al 2012); whereas, the one-trial behavioral sensitization of adult rats is completely context-dependent (Weiss et al 1989; Jackson and Nutt 1993; Battisti et al 1999a, b). The relative importance of associative learning processes may explain why adult rats show a sensitized response for many months after a single exposure to a psychostimulant (Leith and Kuczenski 1982; Robinson et al 1982; Valjent et al 2010), while the one-trial behavioral sensitization of preweanling rats persists for only a few days (McDougall et al 2009a). …”

Section: Introductionmentioning

confidence: 99%

Effects of D2 or combined D1/D2 receptor antagonism on the methamphetamine-induced one-trial and multi-trial behavioral sensitization of preweanling rats

et al. 2015

Self Cite

View full text Add to dashboard Cite

Rationale There is suggestive evidence that the neural mechanisms mediating one-trial and multi-trial behavioral sensitization differ, especially when the effects of various classes of dopamine (DA) agonists are examined. Objective The purpose of the present study was to determine the role of the D2 receptor for the induction of one-trial and multi-trial methamphetamine sensitization in preweanling rats. Methods In a series of experiments, rats were injected with saline or raclopride (a selective D2 receptor antagonist), either alone or in combination with SCH23390 (a selective D1 receptor antagonist), 15 min prior to treatment with the indirect DA agonist methamphetamine. Acute control groups were given two injections of saline. This pretreatment regimen occurred on either postnatal days (PD) 13–16 (multi-trial) or PD 16 (one-trial). On PD 17, rats were challenged with methamphetamine and locomotor sensitization was determined. Results Blockade of D2 or D1/D2 receptors reduced or prevented, respectively, the induction of multi-trial methamphetamine sensitization in young rats, while the same manipulations had minimal effects on one-trial behavioral sensitization. Conclusions DA antagonist treatment differentially affected the methamphetamine-induced sensitized responding of preweanling rats depending on whether a one-trial or multi-trial procedure was used. The basis for this effect is uncertain, but there was some evidence that repeated DA antagonist treatment caused nonspecific changes that produced a weakened sensitized response. Importantly, DA antagonist treatment did not prevent the one-trial behavioral sensitization of preweanling rats. The latter result brings into question whether DA receptor stimulation is necessary for the induction of psychostimulant-induced behavioral sensitization during early ontogeny.

show abstract

Persistence of one-trial cocaine-induced behavioral sensitization in young rats: regional differences in Fos immunoreactivity

Abstract: Persistence of the sensitized response cannot be used to dissociate the one-trial context-dependent and context-independent sensitization of young rats. Fos data indicate that the CP and PFC may be involved in the mediation of short-term behavioral sensitization on PD 22.

Cited by 15 publications

References 48 publications

Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

Ontogeny of methamphetamine-induced and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats

Effects of D2 or combined D1/D2 receptor antagonism on the methamphetamine-induced one-trial and multi-trial behavioral sensitization of preweanling rats

Contact Info

Product

Resources

About