Persistence of the antimicrobials lincomycin, chlortetracycline, and sulfamethazine in prairie wetlands

Cessna, Allan J.; Kuchta, Sandra L.; Waiser, Marley J.; Brua, Robert B.; Bailey, Jonathan

doi:10.1002/jeq2.20034

Cited by 5 publications

(7 citation statements)

References 49 publications

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“…The half‐life of CTC‐enol in the present laboratory study (4.8 h) is shorter than the DT 50 value of 3.3 d reported by Cessna et al. (2020) for the field study dissipation of CTC in a prairie wetland. Two factors may have played a role in the more rapid dissipation of CTC‐enol in the laboratory study.…”

Section: Resultscontrasting

confidence: 67%

“…Using liquid chromatography–tandem mass spectrometric analysis, Cessna et al. (2020) suggested that the formation of such complexes may have contributed to the low recovery via solid‐phase extraction of CTC from fortified natural wetland water.…”

Section: Resultsmentioning

confidence: 99%

“…The relatively low concentrations and detection frequencies may also reflect relatively rapid dissipation in surface waters. Cessna, Kuchta, Waiser, Brua, and Bailey (2020) reported a DT 50 (time required for 50% dissipation) value of 3.3 d for CTC in a prairie wetland, and Loftin, Adams, Meyer, and Surampalli (2008) observed that CTC degraded more rapidly than oxytetracycline and tetracycline in aqueous solution at pH = 7–9.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it was shown to undergo isomerization to iso ‐CTC in microcosms designed to replicate pond systems (Sanderson et al., 2005). Such processes may explain, in part, its relatively short DT 50 value (3.3 d) in a prairie wetland (Cessna et al., 2020). The objective in the present study was to examine in detail the roles of enol‐keto tautomerization, epimerization, and isomerization in the dissipation of CTC (Figure 1a) in wetland water typical of wetlands within the prairie region of Canada.…”

Section: Introductionmentioning

confidence: 99%

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Isomerization of chlortetracycline in prairie wetland water

et al. 2020

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Chlortetracycline (CTC), an antimicrobial administered as a feed additive to cattle, swine, and poultry, is present in the corresponding manure. Land application of raw or processed (composted or stockpiled) manure provides a mechanism by which CTC (and other antimicrobials) enters the environment and becomes available for transport to surface receiving waters via rainfall or snowmelt runoff. Chlortetracycline has been detected in Canadian surface waters, but little has been reported on its fate in aquatic ecosystems. To address this knowledge gap, the dissipation of CTC-enol was monitored in deionized water and water typical of wetlands within the prairie region of Canada. In deionized water, CTC-enol tautomerized to CTC-keto, and both tautomers epimerized to 4-epi-CTC-enol and 4-epi-CTC-keto, respectively. Irreversible isomerization to iso-CTC occurred, which then epimerized to 4-epi-iso-CTC. In wetland water, although tauterization of CTC-enol to CTC-keto occurred, there was no evidence of the formation of the 4-epimers of either CTC-enol or CTC-keto. The major product formed in the wetland water was iso-CTC, some of which epimerized to 4-epi-iso-CTC. Although CTC-enol was shown to tautomerize to CTC-keto, the concentration of CTC-keto remained low in both deionized and wetland water, suggesting that the isomerization of CTC-enol to iso-CTC most likely occurred via CTC-keto. The dissipation of CTC-enol in wetland water was described by pseudo first-order kinetics with a DT 50 (time required for 50% dissipation) value of 4.8 h. The short DT 50 value of CTC and reduced antimicrobial activity of iso-CTC and 4-epi-iso-CTC suggest a lower probability for selection for CTC-resistant bacteria in Canadian Prairie aquatic ecosystems.

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Section: Resultscontrasting

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Isomerization of chlortetracycline in prairie wetland water

et al. 2020

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“…In addition, phytoremediation of VAs from animal liquid waste has shown to be promising (Hu et al 2020 ). Cessna et al ( 2020 ) reported DT 50 (time required for 50% dissipation) values of 3.3 d for CTC, 7 d for SMZ, and 14 d for LIN for Canadian prairie wetlands. However, in our study, apart from CTC, none of the other VAs (SMZ, TYL, MON, LIN, ERY, TC) showed evidence of removal in the CW, with no significant difference between concentrations in catch basin vs. retention ponds/wetland samples.…”

Section: Resultsmentioning

confidence: 99%

Veterinary antimicrobials in cattle feedlot environs and irrigation conveyances in a high-intensity agroecosystem in southern Alberta, Canada

Sura

Larney

Charest

et al. 2022

Environ Sci Pollut Res

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The South Saskatchewan River Basin (SSRB) is considered one of the most intensively farmed regions in Canada, with high densities of livestock and expansive areas of irrigated cropland. We measured concentrations of seven veterinary antimicrobials (VAs) in 114 surface water samples from feedlot environs and 219 samples from irrigation conveyances in the SSRB. Overall, detection frequencies in feedlot environs were 100% for chlortetracycline (CTC) and tetracycline (TC), 94% for monensin (MON), 84% for tylosin (TYL), 72% for lincomycin (LIN), 66% for erythromycin (ERY), and 23% for sulfamethazine (SMZ). For irrigation conveyances, detection frequencies for CTC and TC remained high (94–100%), but dropped to 18% for ERY, 15% for TYL, 10% for MON, and 4% for SMZ. Lincomycin was not detected in irrigation conveyance water. Maximum concentrations of VAs ranged from 1384 µg L−1 (TC) to 17 ng L−1 (SMZ) in feedlot environs while those in irrigation conveyances were 155 ng L−1 (TC) to 29 ng L−1 (ERY). High detection frequencies and median concentrations of VAs in both feedlot environs and irrigation conveyances were associated with high amounts of precipitation. However, an irrigation district (ID) with high livestock density (Lethbridge Northern) did not exhibit higher concentrations of VAs compared to IDs with less livestock, while levels of VAs in irrigation conveyances were less influenced by the degree of surface runoff. The ubiquity of CTC and TC in our study is likely a reflection of its widespread use in intensive livestock operations. Additional investigation is required to link environmental concentrations of VAs with livestock densities and increase our understanding of potential antimicrobial resistance in high-intensity agroecosystems.

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