Persistence of the effects of Cerebrolysin on cognition and qEEG slowing in vascular dementia patients: Results of a 3-month extension study

A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy

“…Most ( n = 15) studies included 1 intervention and 1 control group [13–20, 22, 24, 29–33], 1 study had 3 parallel arms [28], and five studies had no control group [21, 23, 25, 26, 34]. Four studies were carried out in China [13, 31–33], 3 each in Japan [23, 26, 30] and the United Kingdom [16–18], 2 each in Italy [27, 28] and Germany [19, 22], and 1 each in the United States [14], Austria [20], Sweden [25], Greece [29], Romania [24], and Korea [21]. One study was a multisite RCT carried out in Belgium, France, Germany, Italy, the Netherlands, and Spain [15].…”

“…One study was a multisite RCT carried out in Belgium, France, Germany, Italy, the Netherlands, and Spain [15]. Three studies were published in the 1990s [19, 20, 26], 5 studies were published between 2000 and 2004 [14, 25, 27, 28, 30], and the other 13 were published after 2010 [13, 15–18, 21–24, 29, 31–33]. …”

“…Nine studies tested 399 participants with AD [13, 15, 19, 21, 23, 25–28], 7 studies examined 319 participants with MCI [16, 17, 22, 23, 29, 31, 32], 4 studies analysed 156 participants with vascular dementia (VaD) [14, 24, 25, 33], 1 study explored 112 participants with unspecified dementia (all cause) [20], 1 study examined 9 participants with mixed-type dementia (combined AD and vascular pathologies) [25], and 1 study included 60 age-matched controls [28]. Twenty studies [13–16, 18–33] measured global cognition at baseline with the mini mental state examination (MMSE: mean score = 22.0, SD = 2.5).…”

“…Four studies recruited from memory clinics [14, 15, 22, 29], 3 from the community [16–18], 2 from both hospitals and the community [31, 32], 2 from hospital outpatients [25, 30], 2 from hospital inpatients [13, 33], 1 from a medical centre [21], 1 from a nursing home [20], 1 from both outpatient clinics and the community [34], and 1 from a university clinic [23], and 5 did not specify a recruitment location [19, 24, 26–28]. …”

“…All studies examined chronic administration with treatment duration ranging from 4 weeks [24, 25] to 2 years [16–18], with most chronic studies ( n = 8) assessing the effects of a 12-week intervention [13, 19, 21, 26, 30–33]. Ten studies tested herbal interventions [13, 19, 21, 23, 26, 29–33], 8 assessed vitamins (B or E) [16–18, 25, 27, 28] or supplements [15, 22], and 3 tested nootropics [14, 20, 24].…”