Persistent and Chronic Perioperative Pain After Cancer Surgery

Habibi, Behnum; Kim, Chong; Elsharkawy, Hesham

doi:10.1007/s11912-021-01152-5

Cited by 8 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[38] Pain is the core symptom in the T1 T2 period, and some scholars de ne this pain due to surgery as acute pain. [39] Its persistence indicates that patients in the early postoperative period of PLC are still in the recovery stage of surgical trauma. Some studies have shown that acute pain is a signi cant risk factor for persistent chronic postoperative pain, which also affects patients' quality of life and recovery process.…”

Section: Discussionmentioning

confidence: 99%

Exploring early core symptoms in post-hepatectomy patients: a longitudinal study

Zhang,

Li,

Yuan

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Patients with primary liver cancer (PLC) experience a range of symptoms in the early postoperative period. Symptoms include cancer-related symptoms and adverse effects of treatment. Exploring the core symptoms and their dynamics in the early post-hepatectomy patientsmay help provide better symptom management programs. Objective: The purpose of this study was to identify the core symptoms in early post-hepatectomy patients and to explore the trajectory of their dynamics. Methods: 249 participants with PLC underwent curative surgical procedures between March 2021 and September 2022 at the Hepatobiliary Surgery Departments of two Eastern Chinese hospitals. A comprehensive symptom assessment was administered to the patients 1-2 days after surgery (T1) and 1-2 days before discharge (T2). Network analysis was used to identify core symptoms in early post-hepatectomy patients based on symptom severity. Results: The network analysis identified the core symptoms of dry mouth, pain, abdominal distension, lack of appetite, and nausea at T1. In contrast, at T2, lack of appetite, pain, shortness of breath, and disturbed sleep were revealed. At the two early time points, while the results of the network structure test showed no statistically significant difference in the overall symptom network structure, there was a significant difference in the results for the core symptoms. Conclusion: Our study demonstrates the need to identify core symptoms in the early in early post-hepatectomy to improve symptom management in PLC patients. It is crucial to apply network analysis as an essential component of cancer care.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring early core symptoms in post-hepatectomy patients: a longitudinal study

Zhang,

Li,

Yuan

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In this review, we mainly discuss cancer neuropathic pain, which is the most common pattern of pain in cancer patients. In addition to cancer neuropathic pain, treatment-related pain, acting as an unintended consequence or complication of chemotherapy, surgery, and radiotherapy, 36 , 37 , 38 is also briefly mentioned, and listed in Table 1 . Even though treatment-related pain usually apprears due to applied therapies, this symptom can still persist for a long time after treatment.…”

Section: General Overview Of Cancer-related Neuropathic Painmentioning

confidence: 99%

Contribution of immune cells to cancer-related neuropathic pain: An updated review

Pan

Lai

et al. 2023

Mol Pain

View full text Add to dashboard Cite

Given that the incidence of cancer is dramatically increasing nowadays, cancer-related neuropathic pain including tumor-related and therapy-related pain gradually attracts more attention from researchers, which basically behaves as a metabolic-neuro-immune disorder with worse clinical outcomes and prognosis. Among various mechanisms of neuropathic pain, the common underlying one is the activation of inflammatory responses around the injured or affected nerve(s). Innate and adaptive immune reactions following nerve injury together contribute to the regulation of pain. On the other hand, the tumor immune microenvironment involving immune cells, as exemplified by lymphocytes, macrophages, neutrophils and dendritic cells, inflammatory mediators as well as tumor metastasis have added additional characteristics for studying the initiation and maintenance of cancer-related neuropathic pain. Of interest, these immune cells in tumor microenvironment exert potent functions in promoting neuropathic pain through different signaling pathways. To this end, this review mainly focuses on the contribution of different types of immune cells to cancer-related neuropathic pain, aims to provide a comprehensive summary of how these immune cells derived from the certain tumor microenvironment participate in the pathogenesis of neuropathic pain. Furthermore, the clarification of roles of various immune cells in different tumor immune microenvironments associated with certain cancers under neuropathic pain states constitutes innovative biology that takes the pain field in a different direction, and thereby provides more opportunities for novel approaches for the prevention and treatment of cancer-related neuropathic pain.

show abstract

“…Postoperative pain, a type of inflammatory pain, is caused by peripheral tissue damage involving central and peripheral sensitization mechanisms ( 11 , 12 ). Habibi et al ( 13 ) and Ezzatvar et al ( 14 ) indicated that central sensitization is the main cause of prolonged pain and poor analgesic effect. Perioperative acupuncture was reported to achieve the postoperative analgesic effect with less consumptions of analgesic drugs, by blocking harmful stimuli, reducing peripheral and central sensitization and inhibiting neuroplasticity ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of buccal acupuncture on postoperative analgesia in elderly patients undergoing laparoscopic radical gastrectomy: a randomized controlled trial

Zhu,

Yang,

Yang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the efficacy and safety of buccal acupuncture on postoperative analgesia, perioperative stress response and adverse events in elderly patients undergoing laparoscopic radical gastrectomy.MethodsIt was a prospective, outcome assessor-blinded, randomized controlled trial, involving 90 patients aged 65–80 years who were treated with an elective laparoscopic radical gastrectomy. They were randomly assigned to buccal acupuncture group (Group B) and control group (Group C). Buccal acupuncture was applied to patients of Group B before the induction of general anesthesia, while no additional application was given to those in Group C. Patient-controlled intravenous analgesia (PCIA) with sufentanil was postoperatively performed in both groups. Sufentanil consumption and the Visual Analog Scale (VAS) score within 48 h postoperatively were assessed as primary outcomes. Secondary outcomes included peripheral levels of stress markers, intraoperative consumptions of anesthetic drugs and postoperative recovery.ResultsPatients in Group B presented significantly lower VAS scores within 24 h and less consumption of sufentanil within 48 h postoperatively (both p < 0.01). The awaking time, time to extubation and length of stay were significantly shorter in Group B than in Group C (p = 0.005, 0.001 and 0.028, respectively). Compared with Group C, stress response and inflammatory response within 24 h postoperatively were also significantly milder in Group B.ConclusionThe use of buccal acupuncture before general anesthesia induction favors the postoperative analgesic effect and recovery in elderly patients undergoing laparoscopic radical gastrectomy, the mechanism of which involves relieving postoperative stress response and inflammatory response.Clinical trial registrationThis study was registered in the Chinese Clinical Trial Registry (www.chictr.org.cn) on 15/06/2023 (ChiCTR2300072500).

show abstract

Persistent and Chronic Perioperative Pain After Cancer Surgery

Cited by 8 publications

References 41 publications

Exploring early core symptoms in post-hepatectomy patients: a longitudinal study

Exploring early core symptoms in post-hepatectomy patients: a longitudinal study

Contribution of immune cells to cancer-related neuropathic pain: An updated review

Effects of buccal acupuncture on postoperative analgesia in elderly patients undergoing laparoscopic radical gastrectomy: a randomized controlled trial

Contact Info

Product

Resources

About