Persistent and recrudescent infection in cattle following natural infection with Middle Point orbivirus

Cowled, Christopher; Melville, Lorna; Weir, Richard; Walsh, Susan; Gubala, Aneta J.; Davis, S. Scott; Boyle, David

doi:10.1007/s00705-012-1277-z

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…It has been speculated that when the humoral immune response of the host is weak or if the virus in the immune complex is not completely neutralized, mosquitoes biting these vertebrate hosts may be infected, even with low frequency [ 76 ]. This possibility is compatible with the observation that cattle naturally infected with Middle Point orbivirus had prolonged viremia (up to 15 weeks) most frequently in hosts with low antibody levels [ 77 ]. Interestingly, Kyasanur Forest disease virus was re-isolated from the brains and liver of 14 of 18 mice demonstrating no neutralizing antibodies as long as 246 days after intracerebral or intraperitoneal inoculation [ 78 ].…”

Section: Problemssupporting

confidence: 87%

Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?

Kuno

Mackenzie

Junglen

et al. 2017

Viruses

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The rapid succession of the pandemic of arbovirus diseases, such as dengue, West Nile fever, chikungunya, and Zika fever, has intensified research on these and other arbovirus diseases worldwide. Investigating the unique mode of vector-borne transmission requires a clear understanding of the roles of vertebrates. One major obstacle to this understanding is the ambiguity of the arbovirus definition originally established by the World Health Organization. The paucity of pertinent information on arbovirus transmission at the time contributed to the notion that vertebrates played the role of reservoir in the arbovirus transmission cycle. Because this notion is a salient feature of the arbovirus definition, it is important to reexamine its validity. This review addresses controversial issues concerning vertebrate reservoirs and their role in arbovirus persistence in nature, examines the genesis of the problem from a historical perspective, discusses various unresolved issues from multiple points of view, assesses the present status of the notion in light of current knowledge, and provides options for a solution to resolve the issue.

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Section: Problemssupporting

confidence: 87%

Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?

Kuno

Mackenzie

Junglen

et al. 2017

Viruses

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“…A real-time reversetranscription polymerase chain reaction (RT-PCR) assay was developed for MPOV, which showed that more than 150 virus isolates obtained from cattle between 1994 and 2006 were MPOV isolates (9). YUOV (isolate MPOV) infections have been shown to persist in cattle for up to five months with periods of quiescence, followed by recrudescence of the viral titre (10).…”

Section: Yunnan Orbivirusmentioning

confidence: 99%

Zoonotic and emerging orbivirus infections

Attoui¹,

Jaafar²

2015

Rev. Sci. Tech. OIE

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Many novel emerging orbiviruses have been isolated in the past 15 years. Important viruses include Peruvian horse sickness virus (PHSV) and Yunnan orbivirus (YUOV), pathogens of equids which were originally isolated almost simultaneously from 1997 to 1999 in the People's Republic of China, Australia and Peru. YUOV has also been isolated from cattle, sheep and a dog. The isolation of YUOV from a dog is not the first case of an orbivirus being isolated from a carnivore. Bluetongue virus and African horse sickness virus were earlier detected in carnivores which fed on contaminated meat. PHSV and YUOV both offer an opportunity to study the emergence of a single pathogen in geographically distant locations, although the original point of emergence is still unidentified. PHSV has been isolated from horses with neurological disease both in Australia and in Peru (where it is now endemic). Serological and molecular diagnostic assays have been developed for these viruses to assist in their identification and diagnosis. Other orbiviruses, such as Palyam virus and Equine encephalosis virus, have more recently been identified outside their geographical boundaries and may represent a threat to domesticated livestock and horses, respectively. The article also reviews four zoonotic orbivirus species (Corriparta virus, Changuinola virus, Kemerovo virus and Orungo virus) which have been identified in livestock and/or wildlife.

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“…In northern Australia, orbiviruses are highly prevalent [ 3 , 4 , 5 , 6 ]. In addition to the midge-transmitted and agriculturally significant bluetongue virus, a number of mosquito-borne orbiviruses are also detected in this region [ 4 , 6 , 7 , 8 ]. Middle Point orbivirus and Stretch Lagoon orbivirus are often isolated during mosquito or animal sera screening.…”

Section: Introductionmentioning

confidence: 99%

A New Orbivirus Isolated from Mosquitoes in North-Western Australia Shows Antigenic and Genetic Similarity to Corriparta Virus but Does Not Replicate in Vertebrate Cells

Harrison

Warrilow

McLean

et al. 2016

Viruses

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The discovery and characterisation of new mosquito-borne viruses provides valuable information on the biodiversity of vector-borne viruses and important insights into their evolution. In this study, a broad-spectrum virus screening system, based on the detection of long double-stranded RNA in inoculated cell cultures, was used to investigate the presence of novel viruses in mosquito populations of northern Australia. We detected and isolated a new virus (tentatively named Parry’s Lagoon virus, PLV) from Culex annulirostris, Culex pullus, Mansonia uniformis and Aedes normanensis mosquitoes that shares genomic sequence similarities to Corriparta virus (CORV), a member of the Orbivirus genus of the family Reoviridae. Despite moderate to high (72.2% to 92.2%) amino acid identity across all proteins when compared to CORV, and demonstration of antigenic relatedness, PLV did not replicate in several vertebrate cell lines that were permissive to CORV. This striking phenotypic difference suggests that PLV has evolved to have a very restricted host range, indicative of a mosquito-only life cycle.

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Persistent and recrudescent infection in cattle following natural infection with Middle Point orbivirus

Cited by 9 publications

References 12 publications

Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?

Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality?

Zoonotic and emerging orbivirus infections

A New Orbivirus Isolated from Mosquitoes in North-Western Australia Shows Antigenic and Genetic Similarity to Corriparta Virus but Does Not Replicate in Vertebrate Cells

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