Persistent Asthma in Childhood

Söderhäll, Cilla; Schoos, Ann‐Marie Malby

doi:10.3390/children9060820

Cited by 2 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Young children are especially diverse, with numerous and variable phenotypic manifestations in early life corresponding to several outcomes. 1 Despite advances in disease understanding and the availability of effective treatments, asthma remains one of the leading causes of emergency department visits and multiple hospitalizations in children. 2 Numerous classifications of BA based on phenotype and endotype have been proposed.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-146a-5p and microRNA‐210‐3p Correlate with T Regulatory Cells Frequency and Predict Asthma Severity in Egyptian Pediatric Population

Eldosoky

Hammad

Rushdi

et al. 2023

JAA

View full text Add to dashboard Cite

Background: Severe bronchial asthma (BA) affects 5-10% of children, which imposes socioeconomic burden. Therefore, it is crucial to identify biomarkers for risk stratification in children with BA. T regulatory cells (Tregs) play a balancing role in allergic response regulation. We aimed to investigate the relationship between Treg, miR-210-3p, and miR-146a-5p in relation to asthma phenotypes in search of novel biomarkers of disease severity. Methods: This study included 50 children with BA classified into Group 1 (n = 25) children with mild to moderate asthma and Group 2 (n = 25) children with severe asthma. In addition to 26 control subjects. Flow cytometry was used to detect Tregs. Plasma miR-210-3p and miR-146a levels were determined using quantitative real-time PCR. Patients' FEV1 (Forced Expiratory Volume in the first second) was measured. Results: miR-210-3p level correlated negatively with Treg frequency (r = −0.828, P < 0.001) and FEV1 (r = −0.621, P < 0.001). The level of miR-146a-5p positively correlated positively with Treg% (r = 0.303, P = 0.032). ROC curve analysis revealed that miR-210-3p was the most sensitive biomarker of severity, with the area under curve (AUC) = 0.923, 96% sensitivity, and 60% specificity. According to multivariate analysis, miR-210-3p is an independent risk factor for BA severity [OR =3.119, P = 0.030], while miR-146a-5p is a protective factor [OR =0.811, P = 0.049]. Conclusion:Treg frequency is linked to FEV1, miR-146a-5p and miR-210-3p in childhood BA. Upregulation of miR-210-3p is a sensitive biomarker and an independent risk factor for BA severity in Egyptian children.

show abstract

Section: Introductionmentioning

confidence: 99%

MicroRNA-146a-5p and microRNA‐210‐3p Correlate with T Regulatory Cells Frequency and Predict Asthma Severity in Egyptian Pediatric Population

Eldosoky

Hammad

Rushdi

et al. 2023

JAA

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies confirm that one of the major risk factors for asthma is environmental tobacco smoke (ETS). There is also growing evidence that molds are a risk factor, although some studies suggest that molds are only harmful in the bedroom but have a protective effect elsewhere in the house [ 7 ]. In contrast, there is controversy about the role of animal allergens in asthma.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, there is controversy about the role of animal allergens in asthma. Some studies suggest a protective role for animal allergens [ 7 ], while others suggest that they are a risk factor for the development of the disease [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Symptoms, Allergies, and Environmental Exposures in Children with and without Asthma

Wypych-Ślusarska

Grot

Maria

et al. 2022

IJERPH

View full text Add to dashboard Cite

Background: Epidemiological data concerning the level of asthma morbidity indicate that in Poland, asthma is diagnosed in 5–10% of the pediatric population. Aim The purpose of this study was to compare the prevalence of respiratory symptoms and allergies in a group of children with and without asthma and to evaluate the association between exposure to environmental factors and the prevalence of bronchial asthma in a pediatric population. Material and Methods: A cross-sectional study was conducted on a group of 995 children attending primary schools in the province of Silesia in 2018–2019. The research tool was an anonymous questionnaire developed based on the form used in The International Study of Asthma and Allergies in Childhood (ISAAC). Children’s health status, the prevalence of bronchial asthma, and the performance of allergic skin tests were assessed based on parents’ indications in a questionnaire. Environmental exposures such as mold and dampness in apartments or ETS were similarly assessed. Analyses were performed using Statistica 13.0; p < 0.05. Results: A total of 88 subjects (8.8%) suffered from bronchial asthma. Parents of children with asthma, compared to parents of children without the disease, were more likely to rate their children’s health as rather good (43.2% vs. 38.0%) or average (21.6% vs. 3.1%). All analyzed respiratory symptoms, as well as allergies, were statistically more frequent in children with bronchial asthma. Conclusions: The parent’s subjective assessment of the child’s health varied significantly according to the asthma diagnosis. Asthma is also associated with other diseases: allergic reactions to pollen, house dust, hay fever, and AD (atopic dermatitis) were statistically significantly more frequent among children diagnosed with bronchial asthma.

show abstract

Persistent Asthma in Childhood

Abstract: Asthma is the most common chronic disease in children and a cause of great distress for both the children and their families [...]

Cited by 2 publications

References 6 publications

MicroRNA-146a-5p and microRNA‐210‐3p Correlate with T Regulatory Cells Frequency and Predict Asthma Severity in Egyptian Pediatric Population

MicroRNA-146a-5p and microRNA‐210‐3p Correlate with T Regulatory Cells Frequency and Predict Asthma Severity in Egyptian Pediatric Population

Respiratory Symptoms, Allergies, and Environmental Exposures in Children with and without Asthma

Contact Info

Product

Resources

About