Persistent BK polyomavirus‐DNAemia may warrant cystoscopy to rule out urologic carcinoma: A case report and review of the literature

Prom, Alyson; Jorgenson, Margaret R.; Alagusundaramoorthy, Sayee Sundar; Parajuli, Sandesh

doi:10.1111/tid.13316

Cited by 3 publications

(3 citation statements)

References 43 publications

(80 reference statements)

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“…Routine screening for BKV post kidney transplantation was adopted by the Edinburgh transplant unit in 2015, hence four KTR had never had testing for BKV carried out (cases [11][12][13][14]. None of these KTR had micropapillary subtype tumors identified.…”

Section: Patients With No History Of Bkv Infectionmentioning

confidence: 99%

“…Kidney transplant recipients (KTR) have been shown to have a three to four fold increased risk of developing urothelial carcinoma (UC) compared with the general population 1 and UC has been shown to be the most common malignancy in KTR apart from skin malignancies 2,3 . There have been a number of case reports of patients developing UC following kidney transplantation and BK polyoma virus (BKV) infection 4–13 and a large case series examining the development of malignancy in KTR which highlighted BKV infection and smoking as independent risk factors for the development of UC 2 . Primary BKV infection occurs almost universally in childhood.…”

Section: Introductionmentioning

confidence: 99%

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High grade urothelial carcinoma in kidney transplant patients with a history of BK viremia – Just a coincidence?

Cannon,

Ntala,

Joss

et al. 2023

Clinical Transplantation

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IntroductionKidney transplant recipients (KTR) have a three‐to‐four‐fold increased risk of developing urothelial carcinoma (UC) compared to the general population. BK polyoma virus (BKV) infection is known to affect approximately 15% of KTR. In vitro models support a potential pathogenic role for BKV in the development of UC. We describe a series of UC in kidney transplant recipients.MethodsElectronic patient records were searched to identify KTR with UC who had undergone kidney only or simultaneous kidney and pancreas transplantation in a single UK center between 2009 and 2015. Where available, stored pathological samples were retrieved, re‐examined and stained for SV40 as a marker of BKV using standard staining protocols for kidney biopsy samples.ResultsFourteen KTR had developed UC post‐transplant. Of these, 10 KTR had a history of BKV infection post‐transplant. Six of these 10 KTR developed a rare micropapillary tumor subtype of UC which is typically only found in <1% of UC cases. All six micropapillary tumor samples stained positive for SV40, including samples from metastases. Three tumor samples were available from the four KTR with no history of BKV infection and were not micropapillary subtype and were negative for SV40. Three micropapillary tumors from immunocompetent patients were examined as controls and were negative for SV40.ConclusionsThese findings would support a pathogenic role for BK virus in the development of rare micropapillary subtype urothelial tumors in the kidney transplant population.

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Section: Patients With No History Of Bkv Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High grade urothelial carcinoma in kidney transplant patients with a history of BK viremia – Just a coincidence?

Cannon,

Ntala,

Joss

et al. 2023

Clinical Transplantation

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“…BKPyV can also play a direct persistent causal role in bladder carcinoma and other genitourinary cancers. Persistent BKPyV may warrant cystoscopy and evaluation for bladder cancer ( 73 ).…”

Section: Introductionmentioning

confidence: 99%

BK polyomavirus infection: more than 50 years and still a threat to kidney transplant recipients

Parajuli,

Aziz,

Zhong

et al. 2024

Front. Transplant.

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BK polyomavirus (BKPyV) is a ubiquitous human polyomavirus and a major infection after kidney transplantation, primarily due to immunosuppression. BKPyV reactivation can manifest as viruria in 30%–40%, viremia in 10%–20%, and BK polyomavirus-associated nephropathy (BKPyVAN) in 1%–10% of recipients. BKPyVAN is an important cause of kidney graft failure. Although the first case of BKPyV was identified in 1971, progress in its management has been limited. Specifically, there is no safe and effective antiviral agent or vaccine to treat or prevent the infection. Even in the current era, the mainstay approach to BKPyV is a reduction in immunosuppression, which is also limited by safety (risk of de novo donor specific antibody and rejection) and efficacy (graft failure). However, recently BKPyV has been getting more attention in the field, and some new treatment strategies including the utilization of viral-specific T-cell therapy are emerging. Given all these challenges, the primary focus of this article is complications associated with BKPyV, as well as strategies to mitigate negative outcomes.

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2021

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Persistent BK polyomavirus‐DNAemia may warrant cystoscopy to rule out urologic carcinoma: A case report and review of the literature

Cited by 3 publications

References 43 publications

High grade urothelial carcinoma in kidney transplant patients with a history of BK viremia – Just a coincidence?

High grade urothelial carcinoma in kidney transplant patients with a history of BK viremia – Just a coincidence?

BK polyomavirus infection: more than 50 years and still a threat to kidney transplant recipients

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