Persistent Colonization with <i>Tannerella                   forsythensis</i> and Loss of Attachment in Adolescents

Hamlet, Stephen; Ellwood, R.P.; Cullinan, M. P.; Worthington, Helen V; Palmer, Jennifer L.; Bird, P. S.; Narayanan, D.; Davies, Robin; Seymour, G. J.

doi:10.1177/154405910408300309

Cited by 34 publications

(32 citation statements)

References 19 publications

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“…Furthermore, T. forsythia, but not P. gingivalis, was associated with, and predictive of, progressing attachment loss in older individuals with minimal periodontitis (Tran et al, 2001), by the PCR assay used in the current study. T. forsythia was detected more frequently from adolescents with progressing attachment loss than from non-progressing individuals (Hamlet et al, 2004). The current study also detected T. forsythia in health, consistent with its detection in periodontally healthy children, adolescents (Sirinian et al, 2002), and adults (Gmür et al, 1999).…”

Section: Discussionsupporting

confidence: 85%

Subgingival and Tongue Microbiota during Early Periodontitis

Tanner

Paster

et al. 2006

J Dent Res

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Periodontal infections have a microbial etiology. Association of species with early disease would be useful in determining which microbes initiate periodontitis. We hypothesized that the microbiota of subgingival and tongue samples would differ between early periodontitis and health. A crosssectional evaluation of 141 healthy and early periodontitis adults was performed with the use of oligonucleotide probes and PCR. Most species differed in associations with sample sites; most subgingival species were associated with subgingival samples. Few species were detected more frequently in early periodontitis by DNA probes. Porphyromonas gingivalis and Tannerella forsythia (Tannerella forsythensis) were associated with early periodontitis by direct PCR. In conclusion, the microbiota of tongue samples was less sensitive than that of subgingival samples in detecting periodontal species, and there was overlap in species detected in health and early periodontitis. Detection of periodontal pathogens in early periodontitis suggests an etiology similar to that of more advanced disease.

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Section: Discussionsupporting

confidence: 85%

Subgingival and Tongue Microbiota during Early Periodontitis

Tanner

Paster

et al. 2006

J Dent Res

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“…Previous studies showed that the incidence of T. forsythia in the periodontal sulcus positively correlates with the clinical signs of periodontal disease and can be regarded as a risk indicator for attachment and bone loss (15,16,17). According to the work of Tanner et al (31), the incidence of P. gingivalis and T. forsythia in subgingival and tongue samples is associated with early periodontitis compared to the samples isolated from healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Etiological Analysis of Initial Colonization of Periodontal Pathogens in Oral Cavity

et al. 2008

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It is unclear when the initial colonization by periodontal pathogens occurs in the oral cavity. Therefore, we report here the association between specific age groups and the time when the initial colonization by periodontal pathogens occurs in the oral cavity in such groups. Findings are based on an epidemiological analysis of the prevalence of five periodontal pathogens in the oral cavities of a wide range of age populations, from newborn to elderly, who were randomly selected in a geographic region of Brazil. These periodontal pathogens include Campylobacter rectus, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythia and were analyzed in the bacterial samples isolated from gingival sulcus, the dorsum of the tongue, and cheek mucosa of diverse age groups, using a bacterial DNA-specific PCR method. Results indicated that there are distinct age-related groups where initial colonization by the five periodontal pathogens examined in this study can be detected and that the presence of teeth is a permissive factor for colonization by P. gingivalis, P. intermedia, and T. forsythia. Although it remains unclear exactly how or when target pathogens colonize healthy subjects, an understanding of age-related groups does provide a potentially useful tool in the early detection and prevention of periodontitis in healthy individuals.

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“…forsythensis has been shown to be one of three species associated with sites that have converted from periodontal health to disease (31). Indeed, the odds of loss of attachment in adolescents were shown to be 8.16 times greater in subjects colonized by T. forsythensis in a 3-year longitudinal study (11). In adults with a low prevalence and a low severity of periodontitis, subjects persistently colonized with T. forsythensis had 5.3 times higher odds of losing attachment at at least one site compared to the odds for those in whom the organism was not detected or only occasionally detected (33).…”

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confidence: 99%

Culture-Independent Identification of Periodontitis-Associated Porphyromonas and Tannerella Populations by Targeted Molecular Analysis

et al. 2004

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Periodontitis is the commonest bacterial disease of humans and is the major cause of adult tooth loss. About half of the oral microflora is unculturable; and 16S rRNA PCR, cloning, and sequencing techniques have demonstrated the high level of species richness of the oral microflora. In the present study, a PCR primer set specific for the genera Porphyromonas and Tannerella was designed and used to analyze the bacterial populations in subgingival plaque samples from inflamed shallow and deep sites in subjects with periodontitis and shallow sites in age-and sex-matched controls. A total of 308 clones were sequenced and found to belong to one of six Porphyromonas or Tannerella species or phylotypes, one of which, Porphyromonas P3, was novel. Tannerella forsythensis was found in significantly higher proportions in patients than in controls. Porphyromonas catoniae and Tannerella phylotype BU063 appeared to be associated with shallow sites. Targeted culture-independent molecular ecology studies have a valuable role to play in the identification of bacterial targets for further investigations of the pathogenesis of bacterial infections.

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Persistent Colonization with Tannerella forsythensis and Loss of Attachment in Adolescents

Cited by 34 publications

References 19 publications

Subgingival and Tongue Microbiota during Early Periodontitis

Subgingival and Tongue Microbiota during Early Periodontitis

Etiological Analysis of Initial Colonization of Periodontal Pathogens in Oral Cavity

Culture-Independent Identification of Periodontitis-Associated Porphyromonas and Tannerella Populations by Targeted Molecular Analysis

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