Persistent Dyskinesia

Crane, George E.

doi:10.1192/bjp.122.4.395

Cited by 231 publications

(26 citation statements)

References 39 publications

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“…In this report we point out prognostic factors for positive outcome. INeuropsychopharmacology 8:233-239, 1993J brand andFaurbye 1960;Paulson 1968;Crane 1973;Hershon et al 1972;Jeste et al 1979;Glazer et al 1984Glazer et al , 1990, whereas more recently and more frequently, new fIndings about remissions of TO symptomatology in pa tients receiving continuous NL treatment have been published (Casey 1985;1991;Casey et al 1986;Casey and Gardos 1990;Gardos et al 1988;Bergen et al 1989;Morgenstern et al 1987;Glazer et al 1991).…”

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confidence: 99%

Tardive Dyskinesia Outcomes: Clinical and Pharmacologic Correlates of Remission and Persistence

Cavallaro

Regazzetti

Mundo

et al. 1993

Neuropsychopharmacol

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Rtl!ersible tardive dyskinesia (TO) outcomes have been rrported in long-term neuroleptic (NL)-treated patients. I" this study the course of TO outcomes was followed-up F 3 years in a population of 125 institutionalized schizophrenic patients (mean age 57.8 years) receiving continuous NL treatment. Tardive dyskinesia occurrence I1Ui severity were assessed by means of the Rockland Simpson Scale (RSS). The prevalence of TO rose from 39.2% at the first examination to 52.8% at last follow-up aamination; however, 28.6% of TO-affected patients rtCOVered and 30% improved. Significant risk factors for a persistent TO outcome result included age over 56 years, duration of illness over 30 years, and a total RSS score over 22. Cumulative NL exposure, over 3550 g of chloropromazine equivalents, was also a significant risk factor for TO. Results from this study confirm that there is the possibility of improvement and remission in an aged, long-term institutionalized population of TO patients. In this report we point out prognostic factors for positive outcome. INeuropsychopharmacology

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confidence: 99%

Tardive Dyskinesia Outcomes: Clinical and Pharmacologic Correlates of Remission and Persistence

Cavallaro

Regazzetti

Mundo

et al. 1993

Neuropsychopharmacol

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“…Dopamine facilitates the passage of in formation in the striopallidal circuit; that is, its action is reinforcing. In 14% of non-gcriatric schizophrenic patients never exposed to neuroleptics, tardive-dyskinesia-like symptoms and other motor symptoms with involuntary movements were demonstrated [Crane, 1973],…”

Section: Phenomenology and Brain Pathologymentioning

confidence: 99%

An Overview of the Psychopathology of Perception: First Rank Symptoms as a Localizing Sign in Schizophrenia

Sims

1991

Psychopathology

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“…Desde então, o número de substâncias neurolépticas sintetizadas aumentou consideravelmente, trazendo benefícios no tratamento das psicoses, principalmente reduzindo o período de internação dos pacientes 3 . No entanto, logo após a introdução das drogas neurolépticas, sinais extrapiramidais foram observados precocemente no tratamento, desaparecendo com a descontinuação da droga, sendo aliviados por medicamentos antiparkinsonianos 6 .…”

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Prevalência de discinesia tardia em pacientes internados nos hospitais psiquiátricos de Salvador, Bahia, Brasil

Filho

Santos

Medeiros

et al. 1994

Arq. Neuro-Psiquiatr.

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RESUMO -Os autores apresentam estudo transversal da prevalência da discinesia tardia (DT) em pacientes internados em unidades psiquiátricas da cidade de Salvador durante o mês de setembro-1992. Após revisão da literatura, comentam a prevalência média de DT encontrada: 1,65% na população de 2115 pacientes, usando protocolo baseado na escala de Simpson.PALAVRAS-CHAVE: discinesia tardia, prevalência, neurolépticos.The occurrence of tardive dyskinesia on inpatients from Salvador, Bahia, Brazil SUMMARY -The authors present a cross-sudy on the occurrence of tardive dyskinesia (TD) among inpatients of psychiatric units of the city of Salvador during the month of September, 1992. After reviewing the literature, they comment the average prevalence found for TD: 1,65% in a population of 2,115 patients using a protocol based on the Simpson Scale.KEY WORDS: tardive dyskinesia, prevalence, neuroleptic drugs.O aparecimento de clorpromazina, na década de 50, trouxe enorme avanço e esperança no tratamento dos disturbios psiquiátricos. Desde então, o número de substâncias neurolépticas sintetizadas aumentou consideravelmente, trazendo benefícios no tratamento das psicoses, principalmente reduzindo o período de internação dos pacientes 3 . No entanto, logo após a introdução das drogas neurolépticas, sinais extrapiramidais foram observados precocemente no tratamento, desaparecendo com a descontinuação da droga, sendo aliviados por medicamentos antiparkinsonianos 6 . Na própria década de 50, movimentos discinéticos involuntários, às vezes persistentes, foram encontrados tardiamente no tratamento com os neuroléticos 6 . Foram inicialmente denominados de "síndrome bucolingomastigatória" e, subsequentemente, de "síndrome de insuficiência extrapiramidal terminal". O termo discinesia tardia (DT) (discinesia de início tardio e persistente), correntemente utilizado, foi aplicado pela primeira vez em 1964 por Faurbye e col., segundo Marsden 7 . Trata-se de síndrome vinculada ao uso prolongado de neurolépticos, que se caracteriza pelo aparecimento de movimentos hipercinéticos involuntários, afetando predominantemente a língua, lábios e outros músculos faciais, frequentemente acompanhados por movimentos coreoatetósicos, com envolvimento de pernas e tronco 2,8 ' 10

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Persistent Dyskinesia

Cited by 231 publications

References 39 publications

Tardive Dyskinesia Outcomes: Clinical and Pharmacologic Correlates of Remission and Persistence

Tardive Dyskinesia Outcomes: Clinical and Pharmacologic Correlates of Remission and Persistence

An Overview of the Psychopathology of Perception: First Rank Symptoms as a Localizing Sign in Schizophrenia

Prevalência de discinesia tardia em pacientes internados nos hospitais psiquiátricos de Salvador, Bahia, Brasil

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