Persistent fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: Implications for persistent orofacial pain

Zhou, QiQi; Imbe, Hiroki; Dubner, Ronald; Ren, Ke

doi:10.1002/(sici)1096-9861(19990920)412:2<276::aid-cne7>3.0.co;2-9

Cited by 130 publications

(97 citation statements)

References 91 publications

(144 reference statements)

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“…Finally, the close spatial correlation of the spinal AFI signal with c-Fos expression confirmed that the spinal AFI signal is representative of spinal nociceptive activity, since c-Fos is expressed after nociceptive stimulation but not after non-nociceptive stimulation (Hunt et al, 1987). Contralateral AFI activity, although low compared with ipsilateral AFI activity, matched contralateral c-Fos expression, which has been described after acute and chronic stimulation of the orofacial region (Zhou et al, 1999;Ono et al, 2009) and the hindlimb (Hudspith et al, 1999;Ro et al, 2004). Contralateral activity is likely attributable to polysynaptic mechanisms.…”

Section: Discussionsupporting

confidence: 70%

Autofluorescent Flavoprotein Imaging of Spinal Nociceptive Activity

Jongen¹,

Pederzani²,

Koekkoek³

et al. 2010

J. Neurosci.

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Pain arises from activation of peripheral nociceptors, and strong noxious stimuli may cause an increase in spinal excitability called central sensitization, which is likely involved in many pathological pain states. So far, it has not been achieved to simultaneously visualize in vivo both the temporal and spatial aspects of spinal activity, including central sensitization. Using autofluorescent flavoprotein imaging (AFI), an optical technique suitable for mapping activity in nervous tissue, we demonstrate a close temporal and spatial correlation of electrically evoked nociceptive input with the spinal AFI signal, representing spinal neuronal activity. The AFI signal increases linearly with stimulation intensity. Furthermore, we found that the AFI signal was much larger in intensity and size when the same electrical stimulation was applied after the induction of central sensitization by a subcutaneous capsaicin injection. Finally, innocuous palpation of the hindpaw did not evoke an AFI response in naive animals, but after capsaicin injection a strong response was obtained. This is the first report demonstrating simultaneously the temporal and spatial propagation of spinal nociceptive activity in vivo.

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Section: Discussionsupporting

confidence: 70%

Autofluorescent Flavoprotein Imaging of Spinal Nociceptive Activity

Jongen¹,

Pederzani²,

Koekkoek³

et al. 2010

J. Neurosci.

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“…Mechanical stimuli were applied to the lateral face and escape threshold was measured using von-Frey filaments. *: P < 0.05 following CFA injection into the TMJ (4,6,7). Fos protein-LI cells are distributed into two populations; one in the Vi/Vc zone and one in the Vc/C 1,2 zone.…”

Section: Discussionmentioning

confidence: 96%

“…Following peripheral inflammation, Fos studies have revealed that two peaks of Fos protein-like immunoreactive cells (Fos protein-LI cells) are expressed; one in the transition zone between the trigeminal spinal nucleus interpolaris and caudalis (Vi/Vc zone), and one in the caudal laminated region between the caudalis and upper cervical dorsal horn (Vc/C 1,2 zone) (4). Further studies have suggested that these two areas functionally differ in the processing of inflammation-induced nociception in the trigeminal region.…”

Section: Introductionmentioning

confidence: 99%

Activation of trigeminal intranuclear pathway in rats with temporomandibular joint inflammation

et al. 2005

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“…24 While the LI4 region has no direct mapping to the NTS, messages generated by electroacupuncture at LI4 may reach the NTS. Another study indicated that noxious facial stimuli induced the expression of c-fos in the NTS, 25 and electroacupuncture at a facial acupuncture point signifi cantly induced the expression of c-fos in the NTS. …”

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confidence: 99%

Effect of Acupuncture on Perception Threshold: A Randomised Controlled Trial

Yamaguchi

Shibutani

2012

Acupunct Med

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Objective To determine the current perception thresholds (CPTs) for arm and mental foramen areas to enable a quantitative evaluation of the effectiveness of acupuncture treatment. Methods Ninety-eight volunteers enrolled as participants and were randomly assigned to one of three groups: an acupuncture group (34 subjects); a sham acupuncture group (32 subjects) and a waiting group (32 subjects). CPTs for the arm and mental foramen areas were determined before and after acupuncture at LI4 Hegu of the left hand. A Neurometer CPT was used to evaluate the perception threshold at the homolateral mental foramen and arm. For further exploration, thresholds of homolateral and contralateral mental foramina were determined before and after acupuncture in a subgroup of 13 participants in the acupuncture group. Results Acupuncture at LI4 increased the perception thresholds of the left mental foramen in the acupuncture group signifi cantly (p<0.01). The increases were signifi cantly greater than in the control group for all frequencies, and signifi cantly greater than sham acupuncture for 250 Hz and 5 Hz. In the subgroup, only the CPTs at 5 Hz increased signifi cantly for the contralateral mental foramen. Conclusions Acupuncture at LI4 increases the perception threshold in the mandibular area, but not in the arm. This fi nding is probably related to the analgesic effect of acupuncture. INTRODUCTIONPractised in China and other Asian countries for more than 4000 years, acupuncture has considerable potential for pain control. Of the acupuncture points used to induce analgesia, LI4 Hegu has been widely used to control dental pain 1 2 and masticatory muscle pain. 3Despite growing clinical acceptance of acupuncture as a method for alleviating pain of varying causes-notably, musculoskeletal and chronic pain, 4 debate continues about its effi cacy.5 6 The consensus appears to be that poor objective data and problems with quantitative methods and measures in many of the acupuncture studies to date preclude any defi nitive conclusions. For this trial, we used an objective assessment measurement in place Effect of acupuncture on perception threshold: a randomised controlled trial of the more commonly used symptom scales (eg, Visual Analogue Scale).The Neurometer current perception threshold (CPTs) was selected as the objective assessment method owing to its inter-rater reliability and capacity for non-traumatic examination. The three different frequencies targeted were Aβ, Aδ and C fi bres, respectively. Clearly, the use of electrical stimulus means that low frequencies will probably affect all fi bre classes. Based on the threshold current required to evoke a response, it has been shown that acupuncture of peripheral nerves selectively affects the response to stimulus at 5 Hz, 250 Hz and 2000 Hz. Electrodiagnostic tests performed with a Neurometer CPT device (Neurometer NS-3000, Neurotron Inc, Baltimore, Maryland, USA) allowed direct quantitative measurements of peripheral sensory nerve function. This automated electrodiagnosti...

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Persistent fos protein expression after orofacial deep or cutaneous tissue inflammation in rats: Implications for persistent orofacial pain

Cited by 130 publications

References 91 publications

Autofluorescent Flavoprotein Imaging of Spinal Nociceptive Activity

Autofluorescent Flavoprotein Imaging of Spinal Nociceptive Activity

Activation of trigeminal intranuclear pathway in rats with temporomandibular joint inflammation

Effect of Acupuncture on Perception Threshold: A Randomised Controlled Trial

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