2016
DOI: 10.11622/smedj.2016167
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Persistent gastro-oesophageal reflux symptoms despite proton pump inhibitor therapy

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Cited by 11 publications
(11 citation statements)
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“…1 While classically considered a disease of excess acid, up to 50% of patients with GERD experience little to no relief with pharmacologic acid suppression. 2,3 As more is uncovered regarding the pathophysiology and etiologies underlying GERD, it is evident that the development of reflux disease extends beyond acidity of the refluxate. Variance in symptom presentation and response to treatment can be attributed to the composition of refluxate as well as factors at the level of the esophagus, such as structural, mechanical, biochemical, and physiological aspects (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…1 While classically considered a disease of excess acid, up to 50% of patients with GERD experience little to no relief with pharmacologic acid suppression. 2,3 As more is uncovered regarding the pathophysiology and etiologies underlying GERD, it is evident that the development of reflux disease extends beyond acidity of the refluxate. Variance in symptom presentation and response to treatment can be attributed to the composition of refluxate as well as factors at the level of the esophagus, such as structural, mechanical, biochemical, and physiological aspects (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…The drug dispensing regulations of the national health insurance program in Taiwan state that PPI can be used for Los Angeles grade A or B in GERD patients for a maximum of 4 months; thus, we only enrolled participants who took PPI for less than four months. For participants who took PPIs for more than four months, it may result from severe GERD or comorbid with other psychological diseases [45]. Hence, we excluded these participants.…”
Section: Discussionmentioning
confidence: 99%
“…Various agents to treat GERD included proton pump inhibitors (PPIs) and non-steroidal anti-in ammatory drug (NSAID) [9,10]. Among these agents, PPIs has an excellent effect on esophageal mucosal healing by blocking HCl secretion and inhibiting H+/K + ATPase [11,12]. However, long-term use of PPI has a high relapse rate of 11-35%, with complications and side effects.…”
Section: Introductionmentioning
confidence: 99%