Persistent Gastrointestinal Bleeding Due to Angiodysplasia of the Gut in Von Willebrand's Disease

Ramsay, Donald; Buist, T. A. S.; MacLeod, Donald A.; Heading, R C

doi:10.1016/s0140-6736(76)90729-7

Cited by 61 publications

(21 citation statements)

References 11 publications

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“…Consistent with the concept that most lesions result from age‐related vascular degenerative events, symptomatic patients are often in their seventh to eighth decade of life [1]. In addition, MVA may coexist with pulmonary hypertension, liver cirrhosis, chronic renal failure or von Willebrand's disease [2–5]. The clinical management of bleeding MVA is often difficult, as patient's age, concomitant diseases and the presence of diffuse or inaccessible lesions have tobe taken into account [1].…”

Section: Introductionmentioning

confidence: 99%

Long‐lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3‐year pharmacological management

Coppola¹,

Stefano²,

Tufano³

et al. 2002

Journal of Internal Medicine

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Section: Introductionmentioning

confidence: 99%

Long‐lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3‐year pharmacological management

Coppola¹,

Stefano²,

Tufano³

et al. 2002

Journal of Internal Medicine

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“…[1][2][3][4] Supportive therapy is often inadequate to control such episodes, and replacement of the stenotic valve, rather than resection of the affected bowel tract, provides the most effective treatment. 5 In nearly all cases, the largest multimers of plasma von Willebrand factor (vWF) are decreased.…”

mentioning

confidence: 99%

Proteolysis of von Willebrand Factor and Shear Stress–Induced Platelet Aggregation in Patients With Aortic Valve Stenosis

et al. 2000

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Background-Excessive bleeding may complicate congenital cardiac defects. To explain the pathogenesis of this abnormality, we evaluated selected parameters of primary hemostasis in patients with aortic valve stenosis before and after corrective surgery. Methods and Results-We examined shear-induced platelet aggregation with the filter aggregometer test and von Willebrand factor (vWF) structure by evaluating the multimeric distribution and extent of subunit proteolysis. The platelet count was reduced before corrective surgery, and shear-induced platelet aggregation was impaired. Moreover, vWF multimers of higher molecular mass were decreased, and proteolytic subunit fragments were increased. After correction of the cardiac defect, all of these parameters returned to normal. Conclusions-Alterations of vWF and platelet function may contribute to the bleeding diathesis in patients with aortic valve stenosis. Improvement after corrective surgery suggests that the passage of blood through a stenosed aortic valve may result in shear forces that induce vWF interaction with platelets in the circulation and, in turn, trigger platelet clearance, vWF degradation, and the impairment of primary hemostasis.

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“…The terms 'angiodysplasias', 'arteriovenous malformations', and 'vascular ectasias' have been used synonymously [2]. Literature survey revealed an association between vWD and angiodysplasia of GIT, but whether this association is a part of Hereditary Haemorrhagic Telangectasia (HHT) is questionable [3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

A case report of von Willebrand disease complicated with gastric antral angiodysplasia

Hasheni

Perera²,

Ragunathan

2009

Galle Med J

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Persistent Gastrointestinal Bleeding Due to Angiodysplasia of the Gut in Von Willebrand's Disease

Cited by 61 publications

References 11 publications

Long‐lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3‐year pharmacological management

Long‐lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3‐year pharmacological management

Proteolysis of von Willebrand Factor and Shear Stress–Induced Platelet Aggregation in Patients With Aortic Valve Stenosis

A case report of von Willebrand disease complicated with gastric antral angiodysplasia

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