Persistent Inflammation, Stem Cell–Induced Systemic Anti‐Inflammatory Effects, and Need for Repeated Stem Cell Injections: Critical Concepts Influencing Optimal Stem Cell Strategies for Treating Acute Myocardial Infarction and Heart Failure

Epstein, Stephen E.; Lipinski, Michael J.; Luger, Dror

doi:10.1161/jaha.118.008524

Cited by 5 publications

(2 citation statements)

References 19 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MI was confirmed by regional cyanosis and electrocardiographic change (more than two ST segment elevations of 0.1 mV or higher). After this, the M-CSF (500 μg/kg/d) [ 20 ] was given an intraperitoneal injection for the first 5 consecutive days in the MM group.The Sham and MI groups were given an intraperitoneal injection of normal saline. All mice were fed in a barrier environment for 1 week.…”

Section: Introduction Methodsmentioning

confidence: 99%

Macrophage colony-stimulating factor ameliorates myocardial injury in mice after myocardial infarction by regulating cardiac macrophages through the P2X7R/NLRP3/IL-1β signal pathway

Zhang,

Huang,

Zhao

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Introduction Methodsmentioning

confidence: 99%

Macrophage colony-stimulating factor ameliorates myocardial injury in mice after myocardial infarction by regulating cardiac macrophages through the P2X7R/NLRP3/IL-1β signal pathway

Zhang,

Huang,

Zhao

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…By regulating and secreting various immunomodulatory factors, angiogenic factors, and nutritional factors, stem cells can reduce harmful immune responses and inflammation and repair different tissue injuries in different microenvironments [ 27 , 28 ]. Studies have shown that stem cells can treat a variety of diseases such as heart failure and pulmonary fibrosis based on their anti-inflammatory effects [ 29 , 30 ]. Presently, a number of NP-oriented stem cell studies attach importance to the anti-inflammatory effects, as shown in Table 2 .…”

Section: The Role Of Stem Cells In the Peripheral Mechanismmentioning

confidence: 99%

Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism

Liu

Wang

et al. 2020

Stem Cells International

View full text Add to dashboard Cite

Neuropathic pain (NP) is pain caused by somatosensory nervous system injury or disease. Its prominent symptoms are spontaneous pain, hyperalgesia, and allodynia, and the sense of pain is extremely strong. Owing to the complex mechanism, conventional painkillers lack effectiveness. Recently, research on the treatment of NP by stem cells is increasing and promising results have been achieved in preclinical research. In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. We analyzed and summarized the general efficacy and mechanism of stem cells in the treatment of neuropathic pain. We found that the multiple-mechanism approach was different from the single mechanism of routine clinical drugs; stem cells play a role in peripheral mechanism, central mechanism, and disinhibition of spinal cord level that lead to neuropathic pain, so they are more effective in analgesia and treatment of neuropathic pain.

show abstract

One‐Step Rapid Fabrication of Cell‐Only Living Fibers

2019

View full text Add to dashboard Cite

Cellular aggregates are used as relevant regenerative building blocks, tissue models, and cell delivery platforms. Biomaterial‐free structures are often assembled either as 2D cell sheets or spherical microaggregates, both incompatible with free‐form deposition, and dependent on challenging processes for macroscale 3D upscaling. The continuous and elongated nature of fiber‐shaped materials enables their deposition in unrestricted multiple directions. Cellular fiber fabrication has often required exogenously provided support proteins and/or the use of biomaterial‐based sacrificial templates. Here, the rapid (<24 h) assembly of fiberoids is reported: living centimeter‐long scaffold‐free fibers of cells produced in the absence of exogenous materials or supplements. Adipose‐derived mesenchymal stem cell fiberoids can be easily modulated into complex multidimensional geometries and show tissue‐invasive properties while keeping the secretion of trophic factors. Proangiogenic properties studied on a chick chorioallantoic membrane in an ovo model are observed for heterotypic fiberoids containing endothelial cells. These micro‐to‐macrotissues may find application as morphogenic therapeutic and tissue‐mimetic building blocks, with the ability to integrate 3D and 4D full biological materials.

show abstract

Persistent Inflammation, Stem Cell–Induced Systemic Anti‐Inflammatory Effects, and Need for Repeated Stem Cell Injections: Critical Concepts Influencing Optimal Stem Cell Strategies for Treating Acute Myocardial Infarction and Heart Failure

Cited by 5 publications

References 19 publications

Macrophage colony-stimulating factor ameliorates myocardial injury in mice after myocardial infarction by regulating cardiac macrophages through the P2X7R/NLRP3/IL-1β signal pathway

Macrophage colony-stimulating factor ameliorates myocardial injury in mice after myocardial infarction by regulating cardiac macrophages through the P2X7R/NLRP3/IL-1β signal pathway

Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism

One‐Step Rapid Fabrication of Cell‐Only Living Fibers

Contact Info

Product

Resources

About