Persistent polyclonal B-cell lymphocytosis: a case report

Histopathological and molecular features of persistent polyclonal B‐cell lymphocytosis (PPBL) with progressive splenomegaly

“…We report on the occurrence of progressive splenomegaly after two or more years from diagnosis, in five PPBL cases. This observation is intriguing, since only two PBBL cases with a concomitant or subsequent malignant lymphoma have been reported out of a hundred described (de Haan & Pouwels, 2006) since the first report (Gordon et al , 1982), but none of them documented a correlation between the two conditions (Roy et al , 1998), supporting the notion of the benign course of this condition. More recently, in the largest series of PPBL reporting a long‐term follow‐up (median 4·4 years, range: 0·5–29) (Cornet et al , 2008), only three of 111 patients developed a high‐ or low‐grade lymphoma.…”