Persistent secretion of vascular endothelial growth factor into the vitreous cavity in proliferative diabetic retinopathy after vitrectomy

Itakura, Hirotaka; Kishi, Shoji; Kotajima, Nobuo; Murakami, Masami

doi:10.1016/j.ophtha.2004.03.035

Cited by 51 publications

(35 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several reports have shown that the VEGF level was elevated in patients with NVG. [20][21][22] We confirmed that the VEGF level in NVG was extremely high compared with those in other cases. Conversely, three of four (75%) patients with NVG at the second vitrectomy had MCP-1 levels similar to those at the first surgery.…”

Section: Discussionsupporting

confidence: 74%

The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

Sassa

Ishikawa

Asato

et al. 2016

Eye

View full text Add to dashboard Cite

Purpose To determine whether the concentrations of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein (MCP)-1 in the vitreous changed after vitrectomy in patients with proliferative diabetic retinopathy (PDR). Participants Twenty-one eyes of 21 patients who needed a second surgery for PDR were included. The reasons for the second surgery were tractional retinal detachment (TRD), neovascular glaucoma, persistent vitreous hemorrhage, macular pucker, and secondary intraocular lens (IOL) implant. Methods We measured the VEGF and MCP-1 levels using sandwich enzyme-linked immunosorbent assays in vitreous samples collected from patients with PDR before pars plana vitrectomy (without IOL implantation), and from the same patients during the second surgery. Results There was not significant change in mean VEGF concentrations when comparing first (0.81 ± 0.88 ng/ml) and second surgeries (1.09 ± 1.51 ng/ml). The MCP-1 level was significantly elevated at the time of second surgery (2.20 ± 2.21 ng/ml) compared with the first vitrectomy (0.72 ± 0.57 ng/ml). The MCP-1 levels of the second surgery cases with TRD (3.18 ± 2.27 ng/ml) increased significantly compared with those with other complications (1.72 ± 2.10 ng/ml). Conclusions At the second vitrectomy, VEGF did not change significantly in the vitreous of the patients examined. The MCP-1 concentration was markedly elevated at the second vitrectomy, implying an association between the prolonged inflammation after vitrectomy and complications, especially TRD.

show abstract

Section: Discussionsupporting

confidence: 74%

The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

Sassa

Ishikawa

Asato

et al. 2016

Eye

View full text Add to dashboard Cite

show abstract

“…Second, the proinflammatory and proangiogenic environment in eyes with active diabetic FVP provides stronger stimulation for tissue proliferation compared with other disease entities. 14,15,21 Third, the recurrent ERM in eyes with active diabetic FVP may cause greater structural alteration of the macula, thus affecting visual prognosis more than recurrent ERM in other diseases. On the basis of the above considerations, we conducted this study to evaluate the effect of ILM peeling in eyes with active diabetic FVP.…”

Section: Discussionmentioning

confidence: 99%

“…5 Earlier studies have suggested ILM peeling as an adjunct to macular surgery may improve surgical outcomes in certain macular diseases, such as macular holes, [6][7][8] epiretinal membranes, 9,10 and diabetic macular oedema; [11][12][13] however, the effect of ILM peeling in the prevention of postoperative ERM remains unknown in diabetic active FVP, which is characterized by a strong proproliferative biological environment. 14,15 To answer this question, we conducted a prospective, comparative case series study to evaluate the visual and functional outcomes of vitrectomy, with or without ILM removal, in eyes with progressive FVP.…”

Section: Introductionmentioning

confidence: 99%

Pars plana vitrectomy for diabetic fibrovascular proliferation with and without internal limiting membrane peeling

Chang

et al. 2008

Eye

View full text Add to dashboard Cite

Objective To evaluate the anatomical and functional results of internal limiting membrane (ILM) peeling during pars plana vitrectomy for fibrovascular proliferation (FVP) in diabetic retinopathy. Methods The study was a prospective comparative case series in design. Patients undergoing pars plana vitrectomy for mild to moderate diabetic FVP were divided into either Group 1: vitrectomy only, or Group 2: further ILM peeling in the macular area. Best-corrected visual acuity, fundus examination, and optical coherence tomography (OCT) were conducted at 3 and 6 months postoperatively. Results There were 26 eyes of 25 patients in Group 1 (non-ILM peeling) and 23 eyes of 22 patients in Group 2 (ILM peeling). At 6 months postoperatively, OCT-identifiable epiretinal membrane (ERM) was found in 10 of 26 eyes (38.5%) in Group 1and 0 of 23 eyes in Group 2 (P ¼ 0.001) and six eyes (23.1%) in Group 1 developed biomicroscopic ERM, whereas no patients in Group 2 had ERM (P ¼ 0.02) at 6 months. OCT identifiable ERM correlated significantly with central macular thickness (r ¼ À0.58, Po0.001), the presence of intraretinal cystic space (r ¼ 0.60, Po0.001), and fovea depression reappearance (r ¼ 0.36, P ¼ 0.008). Factors associated with poor visual outcome were macular detachment (Po0.001) and non-ILM peeling (P ¼ 0.004). Conclusions This pilot study suggests that ILM peeling during vitrectomy for diabetic fibrovascular proliferative membranes may minimize postoperative ERM formation and improve visual prognosis.

show abstract

“…37,38 An important preventive strategy is laser photocoagulation to eliminate any postoperative neovascular stimulus if existing panretinal photocoagulation is inadequate (including treatment of the peripheral retina). 39 Cryotherapy to the peripheral retina and sclerotomy entry sites has also been advocated. 38 Delayed vitreous cavity haemorrhages are a significant problem for some patients which may fail to clear spontaneously requiring further vitrectomy surgery.…”

Section: Complications After Diabetic Vitrectomymentioning

confidence: 99%

Surgical management of the late complications of proliferative diabetic retinopathy

Newman

2010

Eye

View full text Add to dashboard Cite

The late complications of proliferative diabetic retinopathy (PDR) comprise vitreous haemorrhage, tractional retinal detachment, combined tractional-rhegmatogenous retinal detachment, and severe fibrovascular proliferation (including macular distortion or dragging, tractional macular oedema, and media opacity due to fibrovascular tissue). This article will review the indications, techniques, and outcomes of vitrectomy surgery to treat these conditions. A careful assessment of the surgical anatomy, with particular attention to the configuration of vitreoretinal attachments, is important when determining the precise surgical procedure required. The surgical outcome after diabetic vitrectomy has steadily improved with advances in vitreoretinal surgical instrumentation and technique. Significant post-operative complications may, however, occur including cataract formation, recurrent vitreous cavity haemorrhage (early or delayed), rhegmatogenous retinal detachment, and neovascular glaucoma. Most patients will regain or retain useful vision after diabetic vitrectomy, although the visual outcome does remain unpredictable. The development of adjunctive pharmacotherapy should enable further improvements in visual outcome in the future.

show abstract

Persistent secretion of vascular endothelial growth factor into the vitreous cavity in proliferative diabetic retinopathy after vitrectomy

Cited by 51 publications

References 17 publications

The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

Pars plana vitrectomy for diabetic fibrovascular proliferation with and without internal limiting membrane peeling

Surgical management of the late complications of proliferative diabetic retinopathy

Contact Info

Product

Resources

About