2021
DOI: 10.1002/jmv.26864
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Persistent viral shedding of human adenovirus type 7 in children with severe pneumonia

Abstract: To understand host–pathogen interactions and develop effective prevention and control strategies for human adenovirus (HAdV), it is essential to explore the characteristics of HAdV shedding. Hospitalized children <14 years who had severe HAdV pneumonia were tested for HAdV DNA by quantitative real‐time PCR in nasopharyngeal aspirate (NPA). A total of 132 children were enrolled, including 102 patients with HAdV type 7 (HAdV‐7) infection and 12 patients with HAdV type 3 (HAdV‐3) infection. A total of 1372 qualif… Show more

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Cited by 13 publications
(8 citation statements)
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“…Of these, HAdV-7 and HAdV-3 are the predominant types identified in patients with ARIs, although the detected types may change over time and geography [ 17 ]. In contrast, HAdV-7 infection in children tends to have more severe clinical consequences than HAdV-3 [ 19 21 ]. During the past few decades, outbreaks of pediatric lower respiratory infections caused by HAdV-7 have been reported in China [ 22 – 24 ].…”
Section: Acute Respiratory Tract Infectionsmentioning
confidence: 99%
“…Of these, HAdV-7 and HAdV-3 are the predominant types identified in patients with ARIs, although the detected types may change over time and geography [ 17 ]. In contrast, HAdV-7 infection in children tends to have more severe clinical consequences than HAdV-3 [ 19 21 ]. During the past few decades, outbreaks of pediatric lower respiratory infections caused by HAdV-7 have been reported in China [ 22 – 24 ].…”
Section: Acute Respiratory Tract Infectionsmentioning
confidence: 99%
“…The high pathogenicity could be explained by a shift of dominant subtype from AdV-3 to AdV-7 (19). Compared to AdV-3, AdV-7 showed promoted replication and induced stronger cytokine response, thus causing a more severe airway inflammation and a longer duration of viral shedding (21)(22)(23). Eventually, patients infected with AdV-7 presented with a more severe phenotype: a longer fever, an increased incidence of severe pneumonia and admission to an intensive care unit, and a longer hospital stay (12,(23)(24)(25).…”
Section: Resultsmentioning
confidence: 99%
“…First, although multiplex PCR requires nominal fluorescence to determine a positive result, this method cannot be used to distinguish whether the detected pathogen is a current infection or a colonised pathogen. In addition, it is important to note that viruses take longer to shed in the upper respiratory tract than in the lower respiratory tract [ 37 ]. Future comparative studies that include the viral load measurement in a large sample size is needed.…”
Section: Discussionmentioning
confidence: 99%