Personal Exposure to PM_2.5 Oxidative Potential in Association with Pulmonary Pathophysiologic Outcomes in Children with Asthma

Abstract

Fine particulate matter (PM2.5) with a higher oxidative potential has been thought to be more detrimental to pulmonary health. We aim to investigate the associations between personal exposure to PM2.5 oxidative potential and pulmonary outcomes in asthmatic children. We measured each of the 43 asthmatic children 4 times for airway mechanics, lung function, airway inflammation, and asthma symptom scores. Coupling measured indoor and outdoor concentrations of PM2.5 mass, constituents, and oxidative potential with individual time–activity data, we calculated 24 h average personal exposures 0–3 days prior to a health outcome measurement. We found that increases in daily personal exposure to PM2.5 oxidative potential were significantly associated with increased small, large, and total airway resistance, increased airway impedance, decreased lung function, and worsened scores of individual asthma symptoms and the total symptom score. Among the PM2.5 constituents, organic matters largely of indoor origin contributed the greatest to PM2.5 oxidative potential. Given that the variability in PM2.5 oxidative potential was a stronger driver than PM2.5 mass for the variability in the respiratory health outcomes, it is suggested to reduce PM2.5 oxidative potential, particularly by reducing the organic matter constituent of indoor PM2.5, as a targeted source control strategy in asthma management.

Lung Function in Preschool Children in Low and Middle Income Countries: An Under-Represented Potential Tool to Strengthen Child Health

“…with chimney stove installation at 18 months compared to installation at birth ( 48 ). A Chinese study failed to demonstrate any significant association between PM 2.5 exposure and any of the spirometry lung function measures, however an increase in oscillometry resistance was noted suggesting that oscillometry may be a more sensitive measure ( 49 ). In addition to air pollution, e-waste is a growing concern.…”

RGC-TBRS Personal Air Pollutant Exposure versus Health Condition and Perception Pilot Study for Young Asthmatics in Hong Kong (2019/2020)

“…Results of our pilot study also provide insights on the proper effect size of our followup study. Following the previous studies on personal air pollutant exposure and lung function [10][11][12], we have adjusted the regression coefficients based on one IQR change in PM2.5 exposure level. For one IQR change in personal PM2.5 exposure, the change in FEV1 and FVC was -0.137 and -0.260, respectively.…”

“…We found that the effect size in our study, as represented by the adjusted regression coefficient, is larger than the previous studies (Table 4). * To compare the effects of personal air pollution on health outcomes across different studies, the regression coefficient was calculated as the change in outcome per one IQR change in air pollution level after adjusting for covariates [10][11][12].…”

“…Moreover, PM 1.0 was included in our analysis, given that the adverse health impacts of PM 1.0 may be stronger than PM 2.5 [9]. Further, demographic information, including age (number of years), gender (male or female), and body mass index (BMI), and meteorology information, including temperature (degree Celsius) and relative humidity (%), were included as covariates [10-12]. BMI (kg/m 2 ) is calculated as the body weight divided by the square of the body height.…”

Negative Ion Purifier Effects on Indoor Particulate Dosage to Small Airways

“…Indoor air purifiers are the most common intervention strategy adopted to reduce indoor PM 2.5 exposure, with filtration purifiers being the traditional type of indoor air purifier used [ 6 , 7 ]. Intervention studies have reported the cardiopulmonary benefits of high-efficiency particulate air (HEPA) filtration purifiers in young, healthy adults in a Chinese city with severe ambient particulate air pollution [ 8 ].…”