Personality, catecholamine metabolites, and psychophysiological response to diazepam

Masuda, Minoru; Bakker, Cornelis B.

doi:10.1016/0022-3956(66)90017-3

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Bond, James & Lader (1974a, b), Ashton et al (1972) and Keuchel, Kohnen & Lienert (1979) used arithmetic addition tasks to show changes in performance due to amylobarbitone, oxypertine, and nicotine and caffeine respectively. Masuda & Bakker (1966) showed mathematical performance was reduced by diazepam 10 and 20 mg and similar impairments following repeated doses of diazepam 10-20mg were found by Frostad et al (1966). Using the serial subtraction of numbers technique Hindmarch (1977b) was able to show the sedative effects of flunitrazepam 1 mg and flurezepam 15 mg.…”

Section: Central Processingsupporting

confidence: 77%

Psychomotor function and psychoactive drugs:

Hindmarch¹

2004

Brit J Clinical Pharma

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Section: Central Processingsupporting

confidence: 77%

Psychomotor function and psychoactive drugs:

Hindmarch¹

2004

Brit J Clinical Pharma

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“…Betts et al (1972) Masuda & Bakker (1966) reported significant differences between diazepam and placebo on galvanic skin response and written mathematics tests carried out in two conditions; one in the presence of noise and shock and the other without these distractions. The skin resistance was raised with diazepam, and mathematics performance was reduced.…”

mentioning

confidence: 99%

Effects of benzodiazepines on psychomotor performance.

Wittenborn¹

1979

Brit J Clinical Pharma

119

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Drug-induced behavioural changes may, over time, be influenced also by metabolic adaptations to the substance and by psychological adaptations, including learning to adjust to the primary behavioural consequences of the drug. For these reasons, the subjects examined to show psychomotor effects should be relatively inexperienced with the class of drug under scrutiny. Thus, immediate psychomotor changes, for example, changes during the first day of medication, are assumed to be less subject to ambiguous interpretation than behaviour assessed after repeated administrations of the drug, for example, over a course of treatment. It is proposed, therefore, that optimal subjects for assessing the psychomotor effects per se of benzodiazepines would be normal volunteers assessed in a manner to reflect initial response to the substance.The design of such inquiries should provide for the standard comparison between premedication behavioural assessments and assessments at fixed intervals during a standard period, for example

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“…Examples of the diversity of tests used in psychopharmacological studies include proofreading (5), card sorting (6), pursuit rotor tracking (7), adaptive tracking (8), rudder control (9), multiple limb coordination (10), symbol copying (11), absolute auditory threshold (12), auditory discrimination (13), delayed auditory feedback (14), auditory reaction time (15), choice reaction time (16), ocular convergence (17), the duration of after-images (18), short-and long-term memory (19), verbal learning (20), digit span (21), muscular grip strength (22), body sway (23), beam balancing (24), digit symbol substitution (25), putting caps on ball point pens (26), tapping speed (27), saccadic eye movements (28), the Gibson spiral maze (29), galvanic skin response (30), electroencephalographic changes (31), finding hidden words (32), critical flicker fusion (33), discrimination conditioning of the eyelid response (34), time estimation (35), serial subtraction (36), the Purdue pegboard test (37), concept identification (38), digit cancellation (39), group vigilance (40), category clustering (41), spontaneous reversals of the Necker cube (42), trigram recognition (43), concentration (44), logical reasoning (1), video games for air combat and slalom driving (44,45), navigational plotting (46), mental rotation…”

Section: Types Of Performance Testsmentioning

confidence: 99%

“…Arithmetic skills are reported to be impaired by doses from 10 to 28 mg (30,99,100) and to be unaffected by single doses of 5 mg to doses of 10 mg three times daily [B Biehl, unpublished data; (40,79,91,105)].…”

Section: Laboratory Performance Testsmentioning

confidence: 99%

Performance tests.

Wetherell

1996

Environ Health Perspect

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This paper discusses the use of psychological performance tests to assess the effects of environmental stressors. The large number and the variety of performance tests are illustrated, and the differences between performance tests and other psychological tests are described in terms of their design, construction, use, and purpose. The stressor emphasis is on the effects of drugs since that is where most performance tests have found their main application, although other stressors, e.g., fatigue, toxic chemicals, are mentioned where appropriate. Diazepam is used as an example. There is no particular performance emphasis since the tests are intended to have wide applicability. However, vehicle-driving performance is discussed because it has been the subject of a great deal of research and is probably one of the most important areas of application. Performance tests are discussed in terms of the four main underlying models--factor analysis, general information processing, multiple resource and strategy models, and processing-stage models--and in terms of their psychometric properties--sensitivity, reliability, and content, criterion, construct, and face validity. Some test taxonomies are presented. Standardization is also discussed with reference to the reaction time, mathematical processing, memory search, spatial processing, unstable tracking, verbal processing, and dual task tests used in the AGARD STRES battery. Some comments on measurement strengths and appropriate study designs and methods are included.

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Personality, catecholamine metabolites, and psychophysiological response to diazepam

Cited by 9 publications

References 22 publications

Psychomotor function and psychoactive drugs:

Psychomotor function and psychoactive drugs:

Effects of benzodiazepines on psychomotor performance.

Performance tests.

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