Psychomotor function and psychoactive drugs:

Hindmarch, Ian

doi:10.1111/j.1365-2125.2004.02279.x

Cited by 50 publications

(52 citation statements)

References 68 publications

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“…[21] The significant effect of ω-3FAs in decreasing the CFF (flicker component) frequency threshold compared with the baseline value is indicative of a reduction in the overall integrative activity of the CNS. [22] The non-significant changes in nitrogen species levels that reported in this study may be related to the dual effects of ω-3FAs on the recycling of nitrogen species. Previous reports showed that ω-3FAs activated the endothelial NO synthatase, which led to increase NO production.…”

Section: Discussionmentioning

confidence: 74%

Omega-3 fatty acids improve psychomotor performance via mechanism not related to nitric acid production

Al-Nimer¹,

Al-Kuraishy²,

Al-Gareeb³

2012

Int J Green Pharm

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Omega-3 fatty acids (ω-3FAs) are essential polyunsaturated fats that protect the brain from cognitive impairment. It increases the activity of endothelial nitric oxide synthetase (eNOS) and thereby increases the nitric acid (NO) production. This study aimed to explore the effect of ω-3FAs on psychomotor performance and to relate this effect to the reactive nitrogen species. This study was conducted in . Twenty healthy subjects, allocated randomly from medical college students, were participated in the single blind clinical trial. Participants were divided into two groups, each of ten subjects to receive either placebo or (ω-3FAs) (750 mg single oral dose daily for 5 days). They were asked to perform psychomotor performance before and after 5 days of treatment, and venous blood was obtained for determination of serum nitric oxide (NO) and peroxynitrite (ONOO). ω-3FAs treated group was significantly different from placebo-treated group in reducing choice and motor reaction times as well as the critical flicker frequency threshold. The serum levels of NO and ONOO in ω-3FAs-treated group did not significantly differ from placebo-treated group. Short term supplementation of ω-3FAs improves the psychomotor performance in young healthy subjects via a mechanism not related to the production of nitric oxide production. Inflorescence is a panicle few flowered and fruit is a capsule. The data of the results obtained were presented and discussed.

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Section: Discussionmentioning

confidence: 74%

Omega-3 fatty acids improve psychomotor performance via mechanism not related to nitric acid production

Al-Nimer¹,

Al-Kuraishy²,

Al-Gareeb³

2012

Int J Green Pharm

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“…(b) The Finger Tapping Task (FT) was performed at Time -30 and 20 minutes to measure motor speed, which was expected to increase in response to nicotine. Using the index finger on the dominant hand, participants tapped a key on a computer as quickly as possible for 30 seconds for two successive trials (Hindmarch, 2004). (c) The Immediate Memory Task (IMT) was performed at Times -30 and 10 minutes to measure attention and impulsivity (Dougherty, Marsh, & Mathias, 2002).…”

Section: Methodsmentioning

confidence: 99%

Allopregnanolone association with psychophysiological and cognitive functions during acute smoking abstinence in premenopausal women.

Allen¹,

Al’Absi

Lando³

et al. 2015

Experimental and Clinical Psychopharmacology

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Nicotine response may predict susceptibility to smoking relapse. Allopregnanolone, a neuroactive steroid metabolized from progesterone, has been shown to be associated with several symptoms of nicotine response. We sought to explore the association between allopregnanolone and response to nicotine during acute smoking abstinence in premenopausal women. Participants completed 2 nicotine response laboratory sessions, 1 in their follicular (low allopregnanolone) and 1 in their luteal (high allopregnanolone) menstrual phase, on the fourth day of biochemically confirmed smoking abstinence. During the laboratory sessions, participants self-administered a nicotine nasal spray and completed a timed series of cardiovascular, cognitive, and subjective assessments of response to nicotine. The relationships of allopregnanolone with baseline values and change scores of outcome measures were assessed via covariance pattern modeling. Study participants (n = 77) had a mean age of 29.9 (SD = 6.8) years and smoked 12.2 (4.9) cigarettes per day. Allopregnanolone concentration measured before nicotine administration was positively associated with systolic (β = 0.85, p = .04) and diastolic blood pressure (β = 1.19, p < .001); and self-report of physical symptoms (β = 0.58, p < .001), dizziness (β = 0.88, p < .01), jitteriness (β = 0.90, p = .04), and pleasantness (β = 2.05, p = .04). Allopregnanolone also had significant positive associations with change in cognition following nicotine nasal spray administration, specifically discriminability as a measure of attention (β = 1.15, p = .05) and response bias as a measure of impulsivity (β = 0.13, p = .02). These data suggest that allopregnanolone may be related to cardiovascular and subjective physical state during acute smoking abstinence, as well as cognitive response to nicotine.

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“…13 Results of the DSST test were considered as the count of correct associations between numbers and symbols during a period of 90 seconds. Both tests were measured preoperatively and repeated daily until the patient was discharged.…”

Section: Study Protocolmentioning

confidence: 99%

Postoperative Analgesia and Recovery Course After Major Colorectal Surgery in Elderly Patients: A Randomized Comparison Between Intrathecal Morphine and Intravenous PCA Morphine

Beaussier

Weickmans

Parc

et al. 2006

Regional Anesthesia and Pain Medicine

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Psychomotor function and psychoactive drugs:

Cited by 50 publications

References 68 publications

Omega-3 fatty acids improve psychomotor performance via mechanism not related to nitric acid production

Omega-3 fatty acids improve psychomotor performance via mechanism not related to nitric acid production

Allopregnanolone association with psychophysiological and cognitive functions during acute smoking abstinence in premenopausal women.

Postoperative Analgesia and Recovery Course After Major Colorectal Surgery in Elderly Patients: A Randomized Comparison Between Intrathecal Morphine and Intravenous PCA Morphine

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