“…N significantly predicted depression, anxiety, suicidality, overall mental health problems, and low self-esteem, whereas E predicted alcohol and drug dependence as well as social well-being, self-esteem, and relationship quality. In another longitudinal study, high aggression (related to low A) and low self-control (related to low C) measured at age 17 years predicted a curvilinear developmental pattern of an externalizing factor (adult antisocial behavior, alcohol dependence, and drug dependence) through ages 20, 24, and 29 years (Walton et al, 2016).…”