Personalized Assessment of Insomnia and Sleep Quality in Patients with Parkinson’s Disease

Diaconu, S.; Falup‐Pecurariu, Cristian

doi:10.3390/jpm12020322

Cited by 7 publications

(7 citation statements)

References 105 publications

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“…Conditions of most concern are insomnia and REM sleep behavior disorder, a type of abnormal sleep considered to be the precursor to α-synaptophysin disease, such as Parkinson’s disease; such disordered sleep affects more than 50% of patients with Parkinson’s disease ( Valli et al, 2022 ). In addition, insomnia is one of the most common sleep disorders in Parkinson’s disease and is significantly associated with poor quality of life ( Diaconu and Falup-Pecurariu, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease

Jiang²,

Wen³

et al. 2023

Front. Aging Neurosci.

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ObjectiveThe purpose of this study was to examine the current state of the application of imaging in sleep research in degenerative disease, as well as hotspots and trends.Materials and methodsA search was conducted on the Web of Science Core Collection (WoSCC) between 1 September 2012, and 31 August 2022 for literature related to sleep imaging. This study analyzed 7,679 articles published in this field over the past 10 years, using CiteSpace to analyze tendencies, countries, institutions, authors, and hotspots.ResultsThere were 7,679 articles on the application of imaging to sleep research published by 566 institutions located in 135 countries in 1,428 journals; the number of articles was increasing on a yearly basis. According to keyword analysis, the research direction of the application of imaging in sleep research focused on the effects of degenerative diseases on sleep, such as Parkinson’s disease, Alzheimer’s disease, and small vessel disease. A literature evaluation found that Parkinson’s disease, insomnia, sleep quality, and rapid eye movement sleep behavior disorder were the top research trends in this field.ConclusionA growing body of research has focused on sleep disorders caused by degenerative diseases. In the application of imaging to sleep research, magnetic resonance functional brain imaging represents a reliable research method. In the future, more aging-related diseases may be the subject of sleep-related research, and imaging could provide convenient and reliable evidence in this respect.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease

Jiang²,

Wen³

et al. 2023

Front. Aging Neurosci.

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“…A score higher than 6 is suggestive of patients with insomnia (22). We used the following criteria for grading the severity of insomnia, as proposed by Okajma et al: absent (0-5), mild (6)(7)(8)(9), moderate (10)(11)(12)(13)(14)(15), and severe (16-24) (23).…”

Section: Questionnairesmentioning

confidence: 99%

“…As the co-occurrence of sleep disturbances in people with PD might have several causes, being related to complex motor complications in some of the cases, a personalized approach is advisable for the thorough assessment of sleep complaints in order to establish a comprehensive management plan ( 6 ). The diagnosis and treatment of symptoms during nighttime were reported by patients as an unmet need.…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of intrajejunal levodopa infusion on sleep in people with advanced Parkinson's disease

et al. 2023

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BackgroundSleep disturbances are commonly encountered in people with advanced Parkinson's disease (PD). In these stages, levodopa–carbidopa intestinal gel (LCIG) is recommended for improving motor symptoms, some non-motor dysfunctions, and quality of life in these patients. This study aimed to assess the effects of LCIG on sleep in PD in a longitudinal study.Study designAn open-label observational study in patients with advanced PD undergoing LCIG treatment was carried out.Measures and outcomesIn total, 10 consecutive advanced people with PD were evaluated at the baseline and after 6 months and 1 year, respectively, of LCIG infusion. Sleep parameters were assessed with several validated scales. We assessed the evolution of sleep parameters under LCIG infusion over time and the effects on sleep quality.ResultsSignificant improvement following LCIG was observed in PSQI total score (p = 0.007), SCOPA-SLEEP total score (p = 0.008), SCOPA-NS subscale (p = 0.007), and AIS total score (p = 0.001) at 6 months and 1 year, compared to the baseline. The PSQI total score at 6 months correlated significantly with the Parkinson's Disease Sleep Scale, version 2 (PDSS-2) “disturbed sleep” item at 6 months (p = 0.28; R = 0.688), while the PSQI total score at 12 months significantly correlated with the PDSS-2 total score at 1 year (p = 0.025, R = 0.697) and with the AIS total score at 1 year (p = 0.015, R = 0.739).ConclusionLCIG infusion demonstrated beneficial effects on sleep parameters and sleep quality, which were constant over time for up to 12 months.

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“…[7]. Therefore, the main sleep disturbances (such as insomnia, excessive daytime sleepiness, restless legs syndrome, rapid eye movement sleep behaviour disorder, sleep apnoea) and the sleep quality should be included in clinical routine examination [8].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Fatigue on Sleep and Other Non-Motor Symptoms in Parkinson’s Disease

Diaconu,

Monescu,

Filip

et al. 2024

Brain Sciences

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Fatigue is a common non-motor symptom in Parkinson’s disease (PD), but even so, it may still be underdiagnosed or misdiagnosed in current practice due to its non-specific manifestations. The aims of this study were to investigate the prevalence of fatigue in PD patients compared to healthy controls and to identify the main characteristics and associations of fatigue with other non-motor symptoms and the impact of fatigue on sleep disturbances in Parkinson’s disease. Materials and methods: case–control study in which 131 PD patients and 131 age- and sex-matched controls were enrolled. Main characteristics of fatigue, sleep, and other non-motor symptoms were assessed using specific validated questionnaires. Results: According to the Chalder fatigue scale, fatigue is more prevalent in PD patients (38.16%) compared to healthy controls (26.71%). Fatigue was identified in 46.54% of the PD patients using the Parkinson’s Fatigue Scale (PFS-16). PD patients with fatigue presented a worse motor status, more sleep disturbances (insomnia, daytime sleepiness), a broader spectrum of non-motor symptoms (pain, anxiety, urinary disturbances), worse cognitive performances, a lower level of happiness, and worse quality of life compared to PD patients without fatigue. Conclusion: Fatigue is a common symptom of PD and needs to be assessed, considering its consequences on quality of life. Sleep disturbances have a great influence over fatigue in PD patients.

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Personalized Assessment of Insomnia and Sleep Quality in Patients with Parkinson’s Disease

Cited by 7 publications

References 105 publications

A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease

A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease

Long-term effects of intrajejunal levodopa infusion on sleep in people with advanced Parkinson's disease

The Impact of Fatigue on Sleep and Other Non-Motor Symptoms in Parkinson’s Disease

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