Personalized Bioactive Nasal Supports for Postoperative Cleft Rhinoplasty

Boyer, Christen J.; Woerner, Jennifer E.; Galea, Christopher; Gatlin, Corbin A.; Ghali, Ghali E.; Mills, David K.; Weisman, Jeffery A.; McGee, David J.; Alexander, Jonathan

doi:10.1016/j.joms.2018.03.029

Cited by 18 publications

(17 citation statements)

References 21 publications

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“…A variety of methods to incorporate antibiotics into polymers using 3D printing technologies have been investigated . The earliest reports used inkjet printing [2,3], whereas the majority of subsequent studies have used FDM [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23], and a few studies have used stereolithography [24][25][26][27].…”

Section: Technical Considerationsmentioning

confidence: 99%

“…To avoid heating leading to decreased bioactivity of incorporated antibiotics or antimicrobial agents, investigators have used other techniques such as surface coating or pressure-based extrusion methods. Boyer et al, used singledip coating method to surface coat penicillin onto the surface of 3D-printed nasal stents [13]. Shao et al [25] used pneumatic extrusion-based bioprinter to load silver phosphate into polycaprolactone polymer along with lidocaine to restore irregular bone defect.…”

Section: Technical Considerationsmentioning

confidence: 99%

“…The antibiotic-impregnated construct showed vancomycin release up to the tested duration of 4 weeks in the in vitro model. A nasal support 3D-printed construct study incorporated penicillin into the nasal stent PLA construct and demonstrated inhibition of Escherichia coli growth [13].…”

Section: Summary Of Current Studies: In Vitro Datamentioning

confidence: 99%

“…This collective technique is sometimes referred to as bioactive printing or bioactive 3D printing [1]. Bioactive printing with antibiotic-impregnated constructs has been the focus of several investigations , the majority of which are in vitro studies [2][3][4][8][9][10][11][12][13][14][15][16][17][18]. This promising technology allows for patient-specific medicine with customization of the implant, instrument or other construct, tailoring the concentration of antibiotic, optimizing the placement and distribution of antibiotic within the construct, with rapid assembly.…”

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confidence: 99%

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Antibiotics in 3D-Printed Implants, Instruments and Materials: Benefits, Challengesâ and Future Directions

et al. 2019

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3D printing is an additive manufacturing technology, which permits innovative approaches for incorporating antibiotics into 3D printed constructs. Antibiotic-incorporating applications in medicine have included medical implants, prostheses, along with procedural and surgical instruments. 3D-printed antibioticimpregnated devices offer the advantages of increased surface area for drug distribution, sequential layers of antibiotics produced through layer-by-layer fabrication, and the ability to rapidly fabricate constructs based on patient-specific anatomies. To date, fused deposition modeling has been the main 3D printing method used to incorporate antibiotics, although inkjet and stereolithography techniques have also been described. This review offers a state-of-the-art summary of studies that incorporate antibiotics into 3Dprinted constructs and summarizes the rationale, challenges, and future directions for the potential use of this technology in patient care.

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Section: Technical Considerationsmentioning

confidence: 99%

Section: Technical Considerationsmentioning

confidence: 99%

Section: Summary Of Current Studies: In Vitro Datamentioning

confidence: 99%

mentioning

confidence: 99%

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Antibiotics in 3D-Printed Implants, Instruments and Materials: Benefits, Challengesâ and Future Directions

et al. 2019

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“…Cytocompatible, hydrophilic, and drug-deliverable 3D printed materials and techniques have been recently explored and hold great promise in cell culture models, medical devices, and tissue-engineered substrates [22,23,24,25]. Such materials include 3D printed polyvinyl alcohol (PVA), a water soluble polymer.…”

Section: Introductionmentioning

confidence: 99%

3D Printing for Bio-Synthetic Biliary Stents

et al. 2019

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Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infused with collagen, human placental mesenchymal stem cells (PMSCs), and cholangiocytes. The biofabrication method in the present study examined 3D printing and collagen injection molding for rapid prototyping of customized living biliary stents with clinical applications in the setting of malignant and benign bile duct obstructions. XL-PVA stents showed hydrophilic swelling and addition of radiocontrast to the stent matrix improved radiographic opacity. Collagen loaded with PMSCs contracted tightly around hydrophilic stents and dense choloangiocyte coatings were verified through histology and fluorescence microscopy. It is anticipated that design elements used in these stents may enable appropriate stent placement, provide protection of the stent-stem cell matrix against bile constituents, and potentially limit biofilm development. Overall, this approach may allow physicians to create personalized bio-integrating stents for use in biliary procedures and lays a foundation for new patient-specific stent fabrication techniques.

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Investigations of hybrid infill pattern in additive manufactured tablets: A novel approach towards tunable drug release

Reddy

Sharma

2023

J Biomed Mater Res

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The significance of 3D printing has risen exponentially in biomedical and pharmaceutical applications. Its potential in the field of fabricating drug delivery systems, by virtue of processing biocompatible polymers, has been very lucrative. This work aims to tap the interstitial drug delivery kinetics that are often inaccessible through machine‐specific infill patterns in additive manufactured tablets fabricated using PVA biopolymer as an excipient. In this regard, a myo‐inositol containing tablet has been printed using Fused Deposition Modeling preceded by Hot Melt Extrusion drug loading route. Two machine‐specific infill patterns were taken, namely straight and grid. Later, these two distinct patterns were juxtaposed to obtain novel hybrid infill patterns in the tablets. Then, these tablets and their filament were subjected to various thermal, mechanical, imaging and pharmaceutical characterization tests to assess the feasibility of the research attempt. Finally, dissolution tests were conducted to evaluate their dissolution behavior over a time period. The characterization tests proved the scientific viability of this attempt along with amorphous existence of drug in the polymeric filament. The dissolution results showed favorable drug release by achieving interstitial dissolution timings with surface area/volume (SA/V) ratio being found to be the principal factor.

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Personalized Bioactive Nasal Supports for Postoperative Cleft Rhinoplasty

Cited by 18 publications

References 21 publications

Antibiotics in 3D-Printed Implants, Instruments and Materials: Benefits, Challengesâ and Future Directions

Antibiotics in 3D-Printed Implants, Instruments and Materials: Benefits, Challengesâ and Future Directions

3D Printing for Bio-Synthetic Biliary Stents

Investigations of hybrid infill pattern in additive manufactured tablets: A novel approach towards tunable drug release

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