Expatriation for work presents several challenges before departure, during expatriation, and on the return to the country of origin that can impact the subjective well-being of these professionals. This study evaluated sociodemographic, labor, cultural distance, and intercultural efficacy variables as possible predictors for Subjective Well-being in 238 expatriates on mission in Brazil. The instruments used were a sociodemographic and labor questionnaire, The Satisfaction with Life Scale, The Scores of Cultural Distance, and the Multicultural Personality Questionnaire. The results, analyzed via Stepwise multiple linear regression, revealed a predictor model of SWB consisting of the variables: having children, cultural empathy, social initiative, and emotional stability. The results indicate the need for interventions focusing on subjective well-being aimed at adapting expatriates in Brazil.