Perspectives for Ag<sub>2</sub>S NIR-II nanoparticles in biomedicine: from imaging to multifunctionality

Shen, Yingli; Lifante, José; Ximendes, Erving; Santos, Harrisson D. A.; Ruiz, Diego; Juárez, Beatriz H.; Gutiérrez, Irene Zabala; Vera, Vivian Torres; Rubio-Retama, Jorge; Rodriguez, Emma Martín; Ortgies, Dirk H.; Jaque, Daniel; Benayas, Antonio; Rosal, Blanca del

doi:10.1039/c9nr05733a

Cited by 80 publications

(68 citation statements)

References 121 publications

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“…where the Planck factors are defined in Equation (36). 1 (0) is the relative quantum yield of the lower energetic radiative transition upon selective excitation into state |2⟩ as defined in Equation (60) and can be obtained from a conventional luminescence spectrum at the temperature T < T c (i.e., if r > r c = 4.491). 10 and 20 are the luminescence branching ratios of the radiative transitions of interest also obtainable from a luminescence spectrum over a wide wavelength range that captures all radiative transitions from the excited states |1⟩ or |2⟩ to lower energy levels, respectively.…”

Section: Practical Use Of the Generalized Excited State Dynamics Modementioning

confidence: 99%

A Theoretical Framework for Ratiometric Single Ion Luminescent Thermometers—Thermodynamic and Kinetic Guidelines for Optimized Performance

Suta

Meijerink

2020

Advcd Theory and Sims

208

191

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Luminescence (nano)thermometry is an increasingly important field for remote temperature sensing with high spatial resolution. Most typically, ratiometric sensing of the luminescence emission intensities of two thermally coupled emissive states based on a Boltzmann equilibrium is used to detect the local temperature. Dependent on the temperature range and preferred spectral window, various choices for potential candidates appear possible. Despite extensive experimental research in the field, a universal theory covering the basics of luminescence thermometry is virtually nonexistent. In this manuscript, a general theoretical framework of single ion luminescent thermometers is presented that offers simple, user-friendly guidelines for both the choice of an appropriate emitter and respective embedding host material for optimum temperature sensing. The results show that the optimum performance (thermal response and sensitivity) around T 0 is realized for an energy gap ∆E 21 between thermally coupled levels between 2k B T 0 and 3.41k B T 0. Analysis of the temperature-dependent excited state kinetics shows that host lattices in which ∆E 21 can be bridged by one or two phonons are preferred over hosts in which higher order phonon processes are required. Such a framework is relevant for both a fundamental understanding of luminescent thermometers but also the targeted design of novel and superior luminescent (nano)thermometers.

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Section: Practical Use Of the Generalized Excited State Dynamics Modementioning

confidence: 99%

A Theoretical Framework for Ratiometric Single Ion Luminescent Thermometers—Thermodynamic and Kinetic Guidelines for Optimized Performance

Suta

Meijerink

2020

Advcd Theory and Sims

208

191

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“…NIR is featured with less harmful effect, deeper tissuepenetrating ability, and improved spatial/temporal tissue resolution as compared to traditional ultraviolet (UV) or visible light. [54][55][56][57][58][59] NIR-induced PTT and PDT have developed very fast in the past decade based on the rapid progress of the emerging of versatile photothermal agents (PTAs) or photosensitizers (PSs) in nanoscale. The harnessing of PTAs is necessary because they can substantially augment the PTT efficacy, reduce the NIR power density and mitigate the damage of NIR to normal tissues.…”

Section: Cu-involved Nanoagents For Photonic Hyperthermia and Photodymentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.

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“…Thus, near infrared (NIR) luminescence within the biological transparency windows (BW I: 650-950 nm; BW II: 1000-1350 nm; BW III: 1550-1850 nm) is highly desirable for minimized attenuation of the emitted light to guarantee high temperature precision. While quantum dots rely on a sensitive thermal quenching behavior of their NIR luminescence within physiological temperature regimes and have successfully been employed in various biomedical applications [30][31][32][33][34][35][36], their usage in thermometry still requires careful calibration [37].…”

Section: Introductionmentioning

confidence: 99%

Making Nd3+ a Sensitive Luminescent Thermometer for Physiological Temperatures—An Account of Pitfalls in Boltzmann Thermometry

et al. 2020

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Ratiometric luminescence thermometry employing luminescence within the biological transparency windows provides high potential for biothermal imaging. Nd3+ is a promising candidate for that purpose due to its intense radiative transitions within biological windows (BWs) I and II and the simultaneous efficient excitability within BW I. This makes Nd3+ almost unique among all lanthanides. Typically, emission from the two 4F3/2 crystal field levels is used for thermometry but the small ~100 cm−1 energy separation limits the sensitivity. A higher sensitivity for physiological temperatures is possible using the luminescence intensity ratio (LIR) of the emissive transitions from the 4F5/2 and 4F3/2 excited spin-orbit levels. Herein, we demonstrate and discuss various pitfalls that can occur in Boltzmann thermometry if this particular LIR is used for physiological temperature sensing. Both microcrystalline, dilute (0.1%) Nd3+-doped LaPO4 and LaPO4: x% Nd3+ (x = 2, 5, 10, 25, 100) nanocrystals serve as an illustrative example. Besides structural and optical characterization of those luminescent thermometers, the impact and consequences of the Nd3+ concentration on their luminescence and performance as Boltzmann-based thermometers are analyzed. For low Nd3+ concentrations, Boltzmann equilibrium starts just around 300 K. At higher Nd3+ concentrations, cross-relaxation processes enhance the decay rates of the 4F3/2 and 4F5/2 levels making the decay faster than the equilibration rates between the levels. It is shown that the onset of the useful temperature sensing range shifts to higher temperatures, even above ~ 450 K for Nd concentrations over 5%. A microscopic explanation for pitfalls in Boltzmann thermometry with Nd3+ is finally given and guidelines for the usability of this lanthanide ion in the field of physiological temperature sensing are elaborated. Insight in competition between thermal coupling through non-radiative transitions and population decay through cross-relaxation of the 4F5/2 and 4F3/2 spin-orbit levels of Nd3+ makes it possible to tailor the thermometric performance of Nd3+ to enable physiological temperature sensing.

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Perspectives for Ag₂S NIR-II nanoparticles in biomedicine: from imaging to multifunctionality

Abstract: A critical analysis of the synthesis routes, properties and optical features of Ag2S nanoparticles is presented. The future perspectives of this material for advanced bioimaging are discussed.

Cited by 80 publications

References 121 publications

A Theoretical Framework for Ratiometric Single Ion Luminescent Thermometers—Thermodynamic and Kinetic Guidelines for Optimized Performance

A Theoretical Framework for Ratiometric Single Ion Luminescent Thermometers—Thermodynamic and Kinetic Guidelines for Optimized Performance

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Making Nd3+ a Sensitive Luminescent Thermometer for Physiological Temperatures—An Account of Pitfalls in Boltzmann Thermometry

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Perspectives for Ag2S NIR-II nanoparticles in biomedicine: from imaging to multifunctionality

Abstract: A critical analysis of the synthesis routes, properties and optical features of Ag2S nanoparticles is presented. The future perspectives of this material for advanced bioimaging are discussed.

Cited by 80 publications

References 121 publications

A Theoretical Framework for Ratiometric Single Ion Luminescent Thermometers—Thermodynamic and Kinetic Guidelines for Optimized Performance

A Theoretical Framework for Ratiometric Single Ion Luminescent Thermometers—Thermodynamic and Kinetic Guidelines for Optimized Performance

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Making Nd3+ a Sensitive Luminescent Thermometer for Physiological Temperatures—An Account of Pitfalls in Boltzmann Thermometry

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Perspectives for Ag₂S NIR-II nanoparticles in biomedicine: from imaging to multifunctionality