Perspectives in bioinorganic chemistry of some metal based therapeutic agents

Ahmad, Saeed; Isab, Anvarhusein A.; Ali, Saqib; Al-Arfaj, Abdul Rahman

doi:10.1016/j.poly.2005.11.004

Cited by 144 publications

(71 citation statements)

References 210 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The antimicrobial activity of several Ag(I) complexes of oxygen donor ligands is independent of whether the ligand itself possesses antimicrobial activity and results from the weaker bonding property of the Ag-O bond and the ease of ligand replacement of the Ag(I) complexes with biological ligands such as those with O, N or S donor atoms. The ligands are likely acting as carriers for the Ag(I) ion and the magnitude of the antimicrobial properties of the complexes is related to the ease with which they participate in ligand exchange reactions [57]. The complexation of the coumarin-4-carboxylates to Ag(I) resulted in enhanced antibacterial activity particularly towards E. coli and P. aeruginosa.…”

Section: Antimicrobial Activity Of Coumarin Ligands and Their Ag(i) Cmentioning

confidence: 99%

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

et al. 2014

View full text Add to dashboard Cite

a b s t r a c tA novel series of coumarin-4-carboxylate ligands (2a-2l), their Ag(I) complexes (3a-3l) together with a number of their phenanthroline adducts (4d, 4f and 4g) have been synthesised and characterised. The ligands were prepared by either acid or base hydrolysis of their corresponding esters or by demethylation of a methylated acid derivative. The esters (1a-1i) were synthesised by an aromatic electrophilic substitution reaction between the conjugate base of substituted phenols and a vinyltriphenylphosphonium salt. The novel series of Ag(I) carboxylate complexes were prepared by reaction of silver nitrate with the coumarin ligands in aqueous/alcohol solution. The Ag(I) phenanthroline adducts were prepared by reaction of the Ag(I) complex with 1,10-phenanthroline in aqueous/alcohol solution. A selection of complexes were screened for their in vitro antibacterial activity against Pseudomonas aeruginosa grown planktonically or as a biofilm as well as a number of other clinically important strains, Escherichia coli, MRSA and Staphylococcus aureus. The activity against the P. aeruginosa biofilm was found to be significantly greater than against the planktonic bacteria.

show abstract

Section: Antimicrobial Activity Of Coumarin Ligands and Their Ag(i) Cmentioning

confidence: 99%

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The commercially available antibiotic amoxil is highly effective against the studied bacteria, but its activities against mold and yeasts are poorer than complex 1. The biological activity of the complexes could be attributed to whether or not they possess the tendency of further ligand replacement with the biological ligands such as proteins and DNA [38]. This suggests that Pt in the complex is labile with replacement by biological ligands being possible.…”

Section: Resultsmentioning

confidence: 99%

Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2

et al. 2016

Self Cite

View full text Add to dashboard Cite

The crystal structure of a transplatin-derived complex, trans-[Pt(NH 3 ) 2 (dmtu) 2 ]Cl 2 (dmtu = N,N ' -dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH 3 ) 2 (dmtu) 2 ] 2? cation and two chloride ions. In trans-[Pt(NH 3 ) 2 (dmtu) 2 ] 2? , the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1 H and 13 C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract

show abstract

“…As an example, Bio-CPPs made of metal-histidine [86] or metal-glutamate [87] can serve as model systems for studying metal-protein interactions. Other nanosystems such as AgI/bioCPPs [88,89] and different preparations of micro-and nano-sized Zn-CPPs [90] possess high antibacterial activity with minimal perturbation to human cells, which can be used in the medical and environmental field.…”

Section: Biocompatibility Of Cppsmentioning

confidence: 99%