Perspectives of Breast Cancer Thermotherapies

Abstract

In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carried out alone to eradicate small breast tumors. A recently developed thermotherapy, called magnetic hyperthermia, which involves localized heating of nanoparticles under the application of an alternating magnetic field, is also presented. The advantages and drawbacks of these different thermotherapies are highlighted.

Considerations for the measurement of core, skin and mean body temperatures

“…In these situations, it is brain temperature, and certainly not that of the rectum, that is the clinically relevant and critical deep-body index, as it determines the likelihood of survival and the rationale for continued resuscitation (Tipton and Golden, 2011). The principle highlighted by this example applies to many scenarios including localised infections (Dellinger et al, 2013), as well as to therapeutic, whole-body and regional cooling (Bernard et al, 2002) or heating (Alphandéry, 2014). In such circumstances, targeted temperature monitoring is essential (Werner, 2014).…”

Sub-lethal hyperthermia promotes epithelial-to-mesenchymal-like transition of breast cancer cells: implication of the synergy between hyperthermia and chemotherapy

“…1 Approximately one in eight women is expected to suffer from breast cancer during her lifetime. 2 Despite increased survival rates due to advances in cancer treatment, breast cancer still remains one of the most fatal diseases that lead to death. 1 Chemotherapy combined with mastectomy or radiotherapy is currently regarded as a gold standard for treating breast cancer.…”

Nanoprobe Synthesized by Magnetotactic Bacteria, Detecting Fluorescence Variations under Dissociation of Rhodamine B from Magnetosomes following Temperature, pH Changes, or the Application of Radiation

“…37 This is achieved by introducing a source of iron in the growth medium of these bacteria, which penetrates inside these bacteria and crystallizes into nanominerals. In this work, the source of iron was mixed with a solution of 400 µM rhodamine B to produce fluorescent magnetosomes, designated as MCR400.…”